San Diego Padres vs San Francisco Giants Picks and Predictions August 18th 2025

San Diego Padres vs San Francisco Giants Baseball Mon, Aug 18, 20:40 pm.
San Diego Padres
ML: -141
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San Francisco Giants
ML: 115
Last Updated on

Padres Look to Bounce Back After Dodgers Sweep

The San Diego Padres return home to PETCO Park after a frustrating sweep at the hands of the Dodgers, now trailing Los Angeles by two games in the NL West. They’ll host the struggling San Francisco Giants for a four-game series that begins Monday night.

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The Giants (60-64) finally snapped their seven-game skid with a 7-1 win over Tampa Bay on Sunday, while the Padres (69-55) are just 6-4 in their last ten and may be without Jackson Merrill (ankle) for the opener.

Match Information

  • Sport: Baseball (MLB)
  • Teams: San Francisco Giants vs. San Diego Padres
  • Venue: PETCO Park, San Diego, CA
  • Date: Monday, August 18, 2025
  • Start Time: 9:40 PM ET
  • Broadcast: NBCS Bay Area / Bally Sports San Diego

Betting Odds

MarketOdds
Giants Moneyline+120
Padres Moneyline-142
Total Runs (O/U)7.5

The Giants Can Win If…

Robbie Ray pitches like an ace. Ray (9-6, 2.98 ERA) has been San Francisco’s most consistent starter, but he’s just 1-1 vs. the Padres this season, including a loss last week when he gave up 4 runs in 6 innings. He’ll need sharper command this time against a patient San Diego lineup.

Offensively, the Giants lean on Rafael Devers (23 HR, 81 RBIs), but Willy Adames sparked their last win with heads-up baserunning. San Francisco’s pitching is its strength — 5th-best ERA (3.72) and fewest HR allowed (107). If Ray keeps San Diego quiet early, the Giants can steal this game.

The Padres Can Win If…

Their bats back up Nestor Cortes. Cortes (1-1, 5.71 ERA) has looked decent since arriving at the trade deadline, including 4.2 innings of one-run ball against these same Giants last week. While he won’t pitch deep, San Diego’s 2nd-ranked bullpen ERA (3.59) can cover him.

The Padres rank 6th in batting average (.252) and 7th in OBP, with hitters like Manny Machado and Ramón Laureano (HR in Sunday’s loss) leading the charge. If San Diego’s offense can chase Ray early, their elite pitching staff — holding opponents to an MLB-best .225 batting average — should carry them to victory.

Key Stats Comparison

CategoryGiants (60-64)Padres (69-55)
Last 10 Games3-76-4
Team Batting Avg.241 (20th MLB).252 (6th MLB)
Team HR143 (14th MLB)155 (10th MLB)
Team ERA3.72 (5th MLB)3.59 (2nd MLB)

The Lean

The Padres are -142 favorites, and for good reason: they’ve dominated San Francisco this year, winning 7 of 9 meetings including a sweep last week. Robbie Ray gives the Giants a chance, but San Diego’s deeper lineup and bullpen edge should prevail.

Model Projection: Padres 4, Giants 3

  • Pick: Padres (-142)
  • Total Lean: Under 7.5

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