San Francisco Giants vs Arizona Diamondbacks Picks and Predictions September 10th 2025

San Francisco Giants vs Arizona Diamondbacks September 10th 2025

The Arizona Diamondbacks visit the San Francisco Giants at Oracle Park for an afternoon game. The Diamondbacks have a record of 72-73 and are ranked fourth in the NL West. They are on a two-game losing streak but have won six of their last ten games.

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The Giants hold a record of 73-71, placing them third in the division. They have won seven of their last ten games and are coming off a win. The weather at Oracle Park is expected to be mild with light rain and a breeze blowing in. Eduardo Rodriguez will start for the Diamondbacks, while Carson Seymour takes the mound for the Giants.

Diamondbacks vs Giants Key Information

• Sport: Baseball
• Teams: Arizona Diamondbacks vs. San Francisco Giants
• Venue: Oracle Park in San Francisco, CA
• Date: Wednesday, September 10, 2025
• Betting Odds: Diamondbacks Moneyline -105, Giants Moneyline -112, Diamondbacks Runline -1.5 (+154), Giants Runline +1.5 (-189), Total Over 8.0 (-118), Total Under 8.0 (-104)

The Diamondbacks Can Win If Their Power Hits Continue

The Arizona Diamondbacks are built to score in a hurry. This team’s slugging percentage ranks 2nd in MLB, and with 198 home runs (5th in the league), they have the firepower to turn a solo shot into a multi-run inning. Gabriel Moreno is heating up, and Ketel Marte’s consistent bat adds depth to a lineup capable of explosive bursts.

Eduardo Rodriguez, despite a 5.22 ERA, has looked sharper lately. If he can manage the Giants’ power hitters early and hand the ball off to the bullpen intact, Arizona has the offensive upside to run away with another high-scoring victory.

The Giants Can Win If Their Long Ball Keeps Soaring

The San Francisco Giants enter this matchup with a clear edge in momentum. They crushed Arizona 11-5 earlier, homering seven times in the series and riding a 13-win stretch over the past 16 games. With a solid 3.77 team ERA (6th in MLB) and the fewest homers allowed, they pair pitching reliability with a red-hot offense.

Players like Jung Hoo Lee, Matt Chapman, and Patrick Bailey have been lighting it up. With Carson Seymour on the mound—who recently turned in a cost-effective outing against St. Louis—the Giants have both the arm and the swing to sweep the series.

The Lean

• Moneyline Pick: Diamondbacks at -105
• Projected Score: Diamondbacks 5, Giants 4
• Best Bet: Diamondbacks moneyline
• Total Bet: Over 8.0 runs

With Arizona’s slugging dominance and San Francisco’s willingness to let the long ball fly, the over is highly appealing. For additional betting context, see more MLB picks and expert analysis.

Expanded Analysis

Arizona’s lineup is built for launch: their slugging pace is second only to the league’s elite. Moreno and Marte are finding their rhythm at the plate. On the flip side, the Giants don’t just hit home runs—they prevent them. Leading MLB in the fewest homers allowed means opportunities for Arizona must be maximized when presented.

Pitching Matchups: Inconsistent vs. Promising

Rodriguez can dominate—he threw six shutout innings against the Dodgers and followed it with a one-run gem in his last start. Consistency is the question mark. Seymour, meanwhile, has shown flashes as a rookie, and the Diamondbacks need to maintain scoring pace early if they want to put pressure on him.

Momentum Matters in Playoff Push

San Francisco is surging—13 wins in 16 games is a statement streak. Arizona, meanwhile, is just hanging on, aiming to stay within reach of the wild-card chase. The game feels evenly poised on paper, but momentum gives the Giants a subtle edge—especially with home-field tilt.

For up-to-the-minute lines, head to our MLB scores and odds page.

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