San Francisco Giants vs Kansas City Royals Picks and Predictions May 21st 2025

Last Updated on

San Francisco Giants ace Logan Webb is poised to take center stage once more as he faces the struggling Kansas City Royals on Wednesday afternoon. With the interleague series tied at one game apiece, Webb’s dominant pitching and the Royals’ faltering offense could be the perfect combination to push the Giants to a strong finish on their nine-game homestand.


Royals’ Offense Stuck in a Prolonged Slump

Kansas City enters the series finale having scored three runs or fewer in 10 of their last 11 games, a stretch that’s seen them go just 4-7. The offensive downturn has been particularly alarming in terms of power, with the team managing only four home runs during this cold streak.

Vinnie Pasquantino has been a rare bright spot, contributing half of those long balls and leading the team with eight home runs on the season. His two-run blast on Monday provided the edge in the Royals’ 3-1 victory, though it wasn’t enough to spark a turnaround as they fell 3-2 in Tuesday’s game. Check The latest Baseball Picks from MLB Expert Handicappers


Webb’s Momentum and Matchup History Favor Giants

Webb, now 5-3 with a 2.42 ERA, has been a consistent performer for San Francisco, especially when bouncing back from losses. He’s coming off a commanding 9-1 win over the Oakland Athletics, and while he hasn’t secured back-to-back wins yet this season, Wednesday’s game presents a prime opportunity to change that.

His prior experience against Kansas City also bodes well. In a June 2022 start, Webb dominated the Royals over seven innings, striking out nine while allowing no runs and just five hits.

sas logo

Industry’s Best

MLB Handicapping Membership


Patrick Bailey’s Defensive Brilliance Boosts Giants

Much of San Francisco’s success on Tuesday can be credited to catcher Patrick Bailey, who showcased elite defensive skills. He threw out two would-be base stealers, including Bobby Witt Jr., who represented the potential tying run late in the game.

Giants manager Bob Melvin emphasized the importance of controlling the running game, praising Bailey as one of the best in the league at managing speed threats.

“To beat these guys, like some of the teams we have that run really well, you have to try to control the running game,” said Melvin. “He’s about as good as it gets.”


Royals’ Pitching Depth Tested Amid Injury

The Royals are expected to treat the series finale as a bullpen day after losing Cole Ragans to a groin strain. Left-hander Daniel Lynch IV, who carries an impressive 1.29 ERA across 20 relief appearances, is slated to start. However, he’s pitched no more than two innings in any outing this season, raising questions about Kansas City’s ability to contain the Giants’ lineup across nine innings.


Prospect Watch: Jac Caglianone’s Path to the Majors

The Royals’ offensive issues have fans eager for reinforcements, and Jac Caglianone has generated plenty of buzz. Recently promoted to Triple-A, the No. 6 overall pick in last year’s draft has flashed his potential by hitting .322 with nine home runs and 43 RBIs in just 38 Double-A games.

Still, Royals GM J.J. Picollo remains cautious.

“You want the guy to have success when he comes up. And we know that reps, historically speaking, are what guys need,” Picollo said. “The big leagues are a whole different animal.”


Conclusion: Giants Have Edge in Series Finale

With Logan Webb on the mound and Kansas City’s offensive woes continuing, the Giants appear well-positioned to seal the series and end their homestand on a high note. If Webb can maintain his form and receive support from both the defense and lineup, San Francisco could notch their sixth win in nine games and carry strong momentum into their next series.sing, but his timeline to the majors is still uncertain.

By T. Franklin Smith | April 8, 2025
By T. Franklin Smith | April 1, 2025
spread
moneyline
over/under
San Francisco Giants
-
-
-
-
-
Kansas City Royals
-
-
-
-
-
Mike Williams
Mike Williams | Handicapper

Free Pick found on BestBettor.com. Mike Williams is part of SportsCapping Group.

Mike uses his strong sports knowledge to analyze all the angles to find the most profitable wagers. Iron Mike handicaps MLB, college football, NFL, NBA, and NCAA basketball. I'm an actual sports and gambling junkie!

#1 Baseball
Yesterday
180
Last 7 days
180
Last 3 days
412
Last 30 days
175