San Francisco Giants vs Oakland Athletics Picks and Predictions May 16th 2025

Athletics Return to Bay Area to Face Giants in Riveting Reunion Series

For the first time since their move to West Sacramento, the Oakland Athletics are back in the Bay Area—but not as local rivals. Instead, it’s now a battle of Northern California bragging rights as the A’s visit the San Francisco Giants for a three-game interleague set beginning Friday night.

Both teams enter the series far more competitive than many expected coming into the 2024 season. The A’s sit at 22-22, while the Giants—despite a recent slide—are just four games back of the NL West-leading Dodgers.

Track live odds and game-day insights on our MLB Odds Page.

Pitching Duel: JP Sears vs. Logan Webb

The series opener features two strong arms: JP Sears (4-2, 2.80 ERA) for the A’s and Logan Webb (4-3, 2.60 ERA) for the Giants.

Sears has been dominant in his previous two starts vs. San Francisco, allowing just one earned run across 14.2 innings while striking out 18 batters and walking just one.

Meanwhile, Webb—a NorCal native—understands the atmosphere will still carry Oakland’s legacy. “You’re always going to hear ‘Let’s Go Oakland’ chants,” he said. “It’s just part of the tradition.”

For detailed pitcher matchups and betting advice, explore our Expert MLB Betting Guide.

Return with Emotional Undertones

Though the location’s changed, the emotional ties run deep. Giants manager Bob Melvin, who managed the A’s for over a decade, still holds the club close to his heart.

“They’ve got a good team,” Melvin said. “Especially the young hitters—they’re not easy to pitch to. I’ve talked to other managers; everyone agrees they’re a tough out.”

Friday’s matchup also revives memories of the 1989 Bay Bridge World Series, one of baseball’s most unique chapters.

Catch more historical rivalry stats and today’s predictions on our MLB Picks Page.

A’s Seeking Another Bounce-Back Moment

Oakland is coming off a humbling series loss to the Dodgers, including back-to-back blowout losses. But history shows they respond well—posting a 6-4 record in games following six-run defeats this year.

Manager Mark Kotsay remains confident. “We’ve had losses like this before and bounced back,” he said. “This is just another chance to turn the page.”

With a .500 record and postseason talk not out of the question, the A’s are far from the basement team they were in 2023.

Stay updated with playoff projections and team trends on our MLB Team Page.

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FAQs

Why is this Athletics-Giants series special?
It’s Oakland’s first return to the Bay since relocating to West Sacramento, reviving a rivalry with deep history.

Who is starting the series opener?
JP Sears for the A’s vs. Logan Webb for the Giants—both with ERAs under 3.00.

What is the Athletics’ record right now?
They’re 22-22, showing big improvement from last season.

How has Sears pitched against the Giants?
He’s allowed just one earned run in two starts totaling 14.2 innings.

What’s Logan Webb’s record vs. the A’s?
Webb is 2-2 with a 4.19 ERA in six career starts against Oakland.

Where can I find today’s picks and odds?
Visit our MLB Picks Page and Odds Board for expert insights.