San Francisco Giants vs San Diego Padres Picks and Predictions June 5th 2025

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The San Diego Padres visit the San Francisco Giants at Oracle Park on Thursday, June 5, 2025. The game starts at 3:45 PM and will be shown on SDPA. Fans can expect mild weather with a light breeze and broken clouds during this afternoon game.

San Diego, managed by Mike Schildt, holds a record of 35-24. They are just one game behind in the NL West. The Padres have a strong division record of 9-1. On the mound, Dylan Cease will start, bringing an ERA of 4.67. The Giants, led by Bob Melvin, have a 33-28 record and are four games back in the division. Robbie Ray, with an ERA of 2.43, will start for the Giants.

Padres vs Giants Key Information

  • Sport: Baseball
  • Teams: San Diego Padres vs. San Francisco Giants
  • Venue: Oracle Park in San Francisco, CA
  • Date: Thursday, June 5, 2025
  • Betting Odds: Padres MoneyLine +101, Giants MoneyLine -120

The Padres Can Win If…

The San Diego Padres are coming off a close 3-2 win against the San Francisco Giants. Manny Machado was a standout performer with a perfect 4-for-4 at the plate, driving in two runs. Fernando Tatis Jr. and Brandon Lockridge each contributed with key hits, helping the Padres secure their third straight win.

The Padres have a strong chance to win due to their solid pitching and defense. Their team ERA of 3.54 ranks 8th in the league, and they have held opponents to a batting average of .227, which is 5th best. This strong pitching performance, paired with a lineup that includes hitters like Machado and Tatis Jr., gives them a competitive edge.

The Padres’ lineup features several players who can impact the game. Manny Machado leads the team with a .315 batting average and 29 RBIs, while Gavin Sheets has hit 11 home runs. The combination of strong pitching and a balanced lineup makes the Padres a tough team to beat in this matchup.

The Giants Can Win If…

The San Francisco Giants are coming off a narrow 3-2 loss to the San Diego Padres. Despite the loss, starter Landen Roupp delivered a solid performance with 6 1/3 innings, allowing no runs and striking out five. Heliot Ramos contributed with a home run, driving in two runs, showcasing his ability to impact the game.

The Giants’ pitching staff has been a strong point this season. With a team ERA of 3.06, they rank second in the league. Robbie Ray, the starting pitcher for this game, holds an impressive 2.43 ERA and a 7-1 record, making him a key player in their attempt to secure a win.

Offensively, the Giants have power in their lineup. Heliot Ramos leads the team with 11 home runs, while Wilmer Flores has driven in 47 runs. With a combination of strong pitching and key hitters, the Giants have the tools needed to come out on top in this game.

Looking to place smarter bets on series finales? Browse real-time lines and matchup data on the MLB Odds Page.

The Lean

The Padres are the underdogs with a moneyline of +101, while the Giants are favored at -120. Despite the odds, the model projects the Padres to win with a score of 4-3. The Padres have a strong batting average and rank first in strikeouts, which could give them an edge. Therefore, the recommendation is to pick the Padres to win straight up.

The over/under line is set at 7.5 runs. The model’s projected total for the game is 7 runs. Both teams have solid pitching, with the Giants having a second-ranked ERA and the Padres not far behind. Given these factors, the recommendation is to take the under for this game.

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Robbie Ray, Giants Aim to Even Series Against Padres After Emotional Comeback

For the San Francisco Giants, Wednesday night felt like a turning point. Trailing 5-0 against the San Diego Padres and staring down their third straight low-scoring loss, something finally clicked. Sparked by newcomer Daniel Johnson, the Giants roared back to win 6-5, breaking a streak of 16 straight games with four runs or fewer — their longest offensive drought of the season.

Johnson, freshly promoted from Triple-A, delivered two hits, scored twice, and made a game-saving catch in right-center in the ninth inning that stopped the Padres from reclaiming the lead. “Man, he went a long way for that ball. That was huge,” manager Bob Melvin said postgame. “Next thing you know, you look up and we have six runs. Little different feeling.”

That shift in energy comes just in time as the Giants look to split the four-game set with the Padres in Thursday’s afternoon finale at Oracle Park.

Need help betting this matchup? Dive into expert picks on the MLB Pick Page.

A person in a San Diego Padres jersey is standing on the baseball field, wearing a cap and looking towards the game.

Robbie Ray Brings the Heat as Giants Look to Keep Momentum

San Francisco’s best hope for finishing the series strong comes in the form of Robbie Ray, the veteran lefty who’s been sensational this year. Ray enters the game with a 7-1 record and a 2.43 ERA, fresh off being named National League Pitcher of the Month for May, when he went 4-1 with a 1.38 ERA across six starts.

Despite taking a tough-luck loss in his last outing — a 1-0 defeat to Miami in which he allowed just two hits and one run over seven innings — Ray continues to dominate with precision and poise. Thursday marks his 19th career start against the Padres, against whom he’s gone 5-6 with a 4.27 ERA. However, numbers only tell part of the story.

There’s a long-standing rivalry between Ray and Manny Machado, dating back to their days with the D-backs and Orioles. While Machado got the better of Ray early — homering twice in their first 13 meetings — Ray has shut him down recently, striking him out twice and keeping him hitless over their last six encounters.

Find full team trends, splits, and pitching stats on the MLB Team Page.

FAQ: What Should Fans Expect from Dylan Cease and the Padres?

How has Dylan Cease performed this season?

Cease has had an up-and-down campaign. While his ERA sits at 4.66, he’s held opponents to three or fewer runs in his last eight starts. The Padres have alternated wins and losses in those outings.

Is Cease historically good against the Giants?

Yes, Cease owns a 3-2 record and a 2.76 ERA in six career starts versus San Francisco. He’s shown an ability to keep Giants hitters off balance, though he’ll need offensive support to secure a win.

What’s been the biggest issue for the Padres in this series?

Inconsistency at the plate. While Manny Machado has delivered with five hits in the series, the team as a whole has struggled to string together big innings — a trend that continued in Wednesday’s loss.

Will the Giants lineup changes stick?

Too early to tell, but early returns are promising. Daniel Johnson brought energy and production, and if Dominic Smith can settle in, the offense might finally be turning a corner.

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Mike Williams
Mike Williams | Handicapper

Free Pick found on BestBettor.com. Mike Williams is part of SportsCapping Group.

Mike uses his strong sports knowledge to analyze all the angles to find the most profitable wagers. Iron Mike handicaps MLB, college football, NFL, NBA, and NCAA basketball. I'm an actual sports and gambling junkie!

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