St. Louis Cardinals vs Arizona Diamondbacks Picks and Predictions May 23rd 2025

Last Updated on

D-backs’ Zac Gallen Eyes Rebound Performance vs. Cardinals

Arizona Diamondbacks ace Zac Gallen is facing an uncharacteristically rough start to his 2024 season. As he prepares to take the mound Friday night against the St. Louis Cardinals, Gallen is hoping to put his recent struggles behind him and regain the form that once made him one of the National League’s most reliable arms.

Searching for Stability on the Mound

Gallen (3-5, 5.14 ERA) is coming off a particularly tough outing against the Colorado Rockies in which he allowed six runs on eight hits, including four home runs, across five innings. It was a continuation of a troubling trend, as he has now given up 10 long balls this season — nearly matching last year’s total of 13 in just 10 starts.

Everything You Need To Know About Gambling Is Right Here—Check Out Gambling News.

“I just felt like I didn’t have great stuff tonight, which just makes my job a little bit tougher.”
— Zac Gallen, Arizona Diamondbacks

Despite showing promise in back-to-back wins over the Mets earlier this month, Gallen has regressed in his last two appearances, surrendering 10 runs over 10 2/3 innings. Friday’s start may be a pivotal moment as he looks to reestablish consistency and keep the D-backs competitive in the NL West.

Those keeping an eye on MLB picks will be curious to see whether Gallen can finally turn the corner or if the Cardinals’ recent offensive resurgence will continue.

Cardinals Lean on In-Form Mikolas

St. Louis counters with Miles Mikolas (3-2, 3.77 ERA), who has been in rhythm since an early-season blowup in Boston. Following that April 6 outing, Mikolas has bounced back strong, posting a 2.17 ERA across his last seven starts. He’s kept opposing hitters in check, including a dominant six-inning shutout performance against Kansas City in his most recent outing.

“Everything works off of that fastball command. Keeping guys honest, moving it in, out, up, down and having confidence in my defense and our catchers.”
— Miles Mikolas, St. Louis Cardinals

The Cardinals have won Mikolas’ past four starts, with the right-hander earning the decision in three of them. Against Arizona, he holds a career 2-2 record with a solid 3.26 ERA over six appearances.

St. Louis Offense Looks to Reignite

After dropping two of three to Detroit, the Cardinals are eager to reclaim the momentum that saw them win 12 of 14 games earlier in May. During that hot streak, they scored five or more runs eight times and appeared to finally break out of their offensive inconsistency.

sas logo

Struggling With Inconsistent MLB Results?

Discover the Proven Picks That Deliver Night After Night!

Smart Betting Starts With Smart Picks—Follow The Best Handicappers!

“I think now with guys who have been here for a year or two, now they understand that this is possible.”
— Lars Nootbaar, St. Louis Cardinals

Friday’s matchup between a struggling ace and a surging starter offers the kind of intriguing contrast that could shape the trajectory of both teams heading into the weekend.

spread
moneyline
over/under
St. Louis Cardinals
-
-
-
-
-
Arizona Diamondbacks
-
-
-
-
-
Bb Ultimatecapper Logo
Bobby Babowski
Premium Package
1W / 1L on Baseball
MLB
Money Line
Hunter Price Logo
Hunter Price
Starter Package
0W / 1L on Baseball
MLB
Money Line
S Investors Logo
Sports Investors
Premium Package
0W / 1L on Baseball
MLB
Spread
319 Service Photo Logo
R&R Totals
Starter Package
0W / 1L on Baseball
MLB
Totals
Jimmy Liu Logo
Jimmy Liu
Premium Package
1W / 0L on Baseball
MLB
Totals
Mike Williams
Mike Williams | Handicapper

Free Pick found on BestBettor.com. Mike Williams is part of SportsCapping Group.

Mike uses his strong sports knowledge to analyze all the angles to find the most profitable wagers. Iron Mike handicaps MLB, college football, NFL, NBA, and NCAA basketball. I'm an actual sports and gambling junkie!

#1 Baseball
Yesterday
119
Last 7 days
157
Last 3 days
172
Last 30 days
162