St. Louis Cardinals vs Chicago Cubs Picks and Predictions June 24th 2025

The Chicago Cubs travel to Busch Stadium to take on the St. Louis Cardinals. This NL Central game is set for Tuesday, June 24, 2025, at 7:45 PM. Fans can catch the action on MARQ as the teams compete under the night sky.

The Cubs come into this game with a 46-32 record, showing strength both at home and on the road. They are led by manager Craig Counsell. The Cardinals, managed by Oliver Marmol, hold a 43-36 record and sit three games back in the division. Both teams have a strong home record, making this an exciting matchup. Weather conditions are expected to be very hot with overcast clouds and a light breeze.

Cubs vs Cardinals Key Information

• Sport: Baseball
• Teams: Chicago Cubs vs. St. Louis Cardinals
• Venue: Busch Stadium in St. Louis, MO
• Date: Tuesday, June 24, 2025
• Betting Odds: Cubs MoneyLine -115, Cardinals MoneyLine -102

The Cubs Can Win If…

The Chicago Cubs are looking to bounce back after a tough 8-2 loss to the St. Louis Cardinals. In the game, Pete Crow-Armstrong shined with two doubles and two runs. Carson Kelly and Nico Hoerner also contributed with two hits each.

Despite recent struggles, the Cubs have strong stats that can lead them to victory. They rank 3rd in slugging percentage at .442 and have hit 113 home runs, placing them 4th in the league. Their lineup features power hitters like Seiya Suzuki, who has 20 home runs, and Pete Crow-Armstrong, with 21 home runs.

Jameson Taillon will take the mound for the Cubs, bringing a 3.84 ERA and a 7-4 record. His ability to keep hitters off base is shown by his 1.04 WHIP. With the Cubs’ offensive power and Taillon’s solid pitching, they have a good chance to secure a win against the Cardinals.

The Cardinals Can Win If…

The St. Louis Cardinals recently had a strong performance against the Chicago Cubs, winning 8-2. Matthew Liberatore pitched well, going 7 innings and allowing only 2 earned runs. Key hitters like Lars Nootbaar, Nolan Gorman, and Brendan Donovan each hit home runs, contributing to the team’s success.

St. Louis is ranked 5th in batting average and on-base percentage in the league, with a .255 average and .326 OBP. Their ability to get on base consistently helps them create scoring opportunities. The Cardinals also have 135 doubles, placing them 5th in the league, which shows their knack for hitting extra-base hits.

Michael McGreevy will start for the Cardinals, boasting a 2.70 ERA and a 0.84 WHIP. His strong pitching can limit the Cubs’ offense. With solid performances from both their hitters and pitchers, the Cardinals have a good chance to win this game.

The Lean

The Cubs are favored with a moneyline of -115. Our model projects the Cubs to win with a score of 5-4. The Cubs have a strong slugging percentage, ranked 3rd, which gives them an edge in scoring runs. The Cardinals’ pitching, with an ERA ranked 17th, might struggle against the Cubs’ hitting.

The over/under line is set at 9.0. Our model projects a total score of 9, which aligns with the line. Both teams have average pitching stats, with ERAs ranked 16th and 17th. This suggests a game with moderate scoring, so the recommendation is to take the over, expecting both teams to reach the projected total.

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Cardinals’ Lefty Power Surge Looks to Close Gap on Cubs

The St. Louis Cardinals are sending a clear message to the rest of the NL Central: they are back in the race. After a dominant victory in the series opener, the St. Louis Cardinals will look to tighten the division standings even further on Tuesday night when they host the first-place Chicago Cubs.

The Left-Handed Power Company

The Cardinals have won six of their last seven games, and their recent surge has been fueled by a surprising source: a power explosion from their left-handed hitters. In Monday’s 8-2 victory, lefties Alec Burleson, Lars Nootbaar, Nolan Gorman, and Brendan Donovan all hit two-run homers. For a team that ranked near the bottom of the league in home runs for most of the season, the sudden power display is a welcome sight.

“The lefties did a really nice job there with the homers,” manager Oliver Marmol said. “I liked our approach… some powerful swings… loved every second of it.”

Chicago’s Pitching Problem

While the Cardinals’ bats are heating up, the Cubs’ pitching has gone ice-cold. Chicago has allowed a staggering 46 runs over its last five games, a major reason for their recent 1-4 slide. They will turn to veteran Jameson Taillon (7-4, 3.84 ERA) to stop the bleeding, but he is coming off a rough start where he struggled with his command.

“Just didn’t do a good job of throwing first-pitch strikes,” a self-critical Taillon said. “(I) didn’t throw any good sliders today.” The struggles of a top team’s pitching staff is a key factor analyzed in our expert betting guide.

A Duel of Pitchers Seeking a Spark

Tuesday’s pitching matchup features two right-handers looking to build positive momentum. While Taillon tries to bounce back, the Cardinals will start Michael McGreevy (1-1, 2.70 ERA). McGreevy, who has spent most of the year in Triple-A, was excellent in his last start, holding the White Sox to one run over five innings. He’ll be making his first career start against the rival Cubs. This matchup will be a key focus on the scores and odds board.

Controlling Their Own Destiny

With Monday’s win, the Cardinals have climbed to within 3 1/2 games of the Cubs, turning this four-game set into a crucial opportunity to make up ground. “You want to control your own destiny sooner than later,” Marmol said. “The only way to do that is one game at a time.”

As these two classic MLB teams battle for position, the intensity is sure to be high. To see who our experts think will win this divisional showdown, check out our daily MLB picks.