St. Louis Cardinals vs Chicago Cubs Picks and Predictions June 25th 2025

St. Louis Cardinals vs Chicago Cubs MLB Wed, Jun 25, 18:45 pm.
St. Louis Cardinals
ML: 110
0
0
Chicago Cubs
ML: -137
Last Updated on

The Chicago Cubs will visit the St. Louis Cardinals at Busch Stadium on Wednesday, June 25, 2025. This night game is set to start at 7:45 PM and will be broadcast on FDSMW. The weather forecast predicts a very hot day with a light breeze and broken clouds.

Both teams are part of the NL Central division. The Cubs, managed by Craig Counsell, have a season record of 46-33. They have performed well on the road with a 21-18 record. The Cardinals, led by Oliver Marmol, hold a 44-36 record and are two games back in the division. They have been strong at home with a 26-15 record. Starting on the mound for the Cubs is Matthew Boyd, while Erick Fedde will pitch for the Cardinals.

Cubs vs Cardinals Key Information

  • Sport: Baseball
  • Teams: Chicago Cubs vs. St. Louis Cardinals
  • Venue: Busch Stadium in St. Louis, MO
  • Date: Wednesday, June 25, 2025
  • Betting Odds: Cubs MoneyLine -132, Cardinals MoneyLine +111

The Cubs Can Win If…

The Chicago Cubs recently played a close game against the St. Louis Cardinals, losing 8-7. They had 13 hits, including two home runs from Nico Hoerner and Seiya Suzuki. These performances highlight the Cubs’ strong batting lineup, capable of generating runs.

The Cubs have a solid batting average of .255, ranking 4th in the league. Their slugging percentage is .443, placing them 3rd. With 115 home runs this season, their power at the plate is evident, making them a threat in any game.

Matthew Boyd will start for the Cubs, bringing an ERA of 2.84 and a WHIP of 1.14. His consistency on the mound gives the Cubs a good chance to control the game. Boyd’s performance could be key to securing a win against the Cardinals.

The Cardinals Can Win If…

The St. Louis Cardinals are coming off an exciting 8-7 win against the Chicago Cubs. Masyn Winn led the way with 4 RBIs, while Lars Nootbaar and Nolan Gorman each added a home run. The Cardinals’ offense collected 10 hits, including 3 home runs, showing their ability to score runs in key moments.

Key stats highlight the Cardinals’ strengths. They rank 3rd in the league with a .256 batting average and 4th in doubles with 137. These numbers show their ability to get on base and hit for power, which can be crucial in securing a win.

Erick Fedde will start for the Cardinals, bringing a 3.54 ERA to the mound. He has been reliable, and with the Cardinals’ strong lineup, they have a good chance to support him with runs. The combination of solid pitching and a potent offense makes the Cardinals a strong contender in this game.

The Lean

The Cubs are favored with a MoneyLine of -132 against the Cardinals, who sit at +111. The Cubs have a slight edge in batting, ranking 4th in batting average and 3rd in slugging percentage. The model projects the Cubs to win with a score of 5-4.

The total for the game is set at 9.0 runs. Both teams have similar earned run averages, but the Cubs have a slight edge in home runs and slugging. The model projects a total of 9 runs, so the recommendation is to take the over at 9.0.

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Cardinals Flex Their Muscles, Look to Keep Rolling Against Cubs

The St. Louis Cardinals are beating the Chicago Cubs at their own game, and it has put them right back in the thick of the National League Central race. Powered by the long ball, the St. Louis Cardinals will look for their third straight win against the division-leading Chicago Cubs on Wednesday night.

A Powerful Statement

The Cardinals have won seven of their last eight games, and their offense has come alive in this series. They have launched seven home runs in the first two games, with left-handed hitters Nolan Gorman, Lars Nootbaar, and Brendan Donovan all contributing to the power surge. After an 8-2 win on Monday, they followed it up with an 8-7 victory on Tuesday, moving to just 2 1/2 games behind the Cubs in the standings.

“Our guys continue to play every pitch with a ton of heart,” Cardinals manager Oliver Marmol said. “We feel good about our guys taking good at-bats and being able to throw up some runs.”

A player in a gray St. Louis Cardinals jersey with red accents stands on the field, focused and ready for play, in front of a dark background.

Chicago’s Pitching Problem

While the Cardinals’ bats are hot, the Cubs’ pitching has been ice-cold. Chicago has been shelled for 54 runs over their last six games, a shocking collapse for a first-place team. They will turn to veteran lefty Matthew Boyd (6-3, 2.84) to stop the bleeding. Boyd has been excellent recently, allowing two runs or fewer in five straight appearances, but he is coming off a start where he was forced to exit early with a bruised shoulder after being hit by a line drive. How a team deals with a sudden pitching slump is a major factor, a topic discussed in our expert betting guide.

A Tale of Two Starters

Wednesday’s pitching matchup features two arms with different recent fortunes. While Boyd has been sharp for the Cubs, the Cardinals will start right-hander Erick Fedde (3-6, 3.54 ERA), who is on a seven-start personal winless streak. Fedde has pitched well during that stretch but has been the victim of poor run support. With his offense now clicking, he has a great chance to finally get back in the win column. This matchup is a key focus on the scores and odds board.

Controlling Their Own Destiny

With seven games against the Cubs in a 14-day span, the Cardinals know this is their best chance to make up ground on their rival. “You want to control your own destiny sooner than later,” Marmol said. “The only way to do that is one game at a time.” As these two historic MLB teams battle for position, the intensity is sure to be high. To see who our experts think will win this divisional showdown, check out our daily MLB picks.

spread
moneyline
over/under
St. Louis Cardinals
-
-
110
O 8.5
-125
Chicago Cubs
-
-
-137
U 8.5
100
Mike Williams
Mike Williams | Handicapper

Free Pick found on BestBettor.com. Mike Williams is part of SportsCapping Group.

Mike uses his strong sports knowledge to analyze all the angles to find the most profitable wagers. Iron Mike handicaps MLB, college football, NFL, NBA, and NCAA basketball. I'm an actual sports and gambling junkie!

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