St. Louis Cardinals vs Kansas City Royals Picks and Predictions June 4th 2025

St. Louis Cardinals vs Kansas City Royals June 4th 2025

The Kansas City Royals are set to play the St. Louis Cardinals at Busch Stadium on Wednesday, June 4, 2025. The game will start at 7:45 PM and will be broadcasted on FDSKC. The weather forecast details are not available, but fans can expect an outdoor experience at this night game.

Kansas City enters with a 32-29 record, sitting 7 games back in the AL Central. They have a road record of 13-16. On the mound for the Royals is Noah Cameron, who has an impressive ERA of 1.05. St. Louis holds a 33-27 record and is 5 games back in the NL Central. The Cardinals have a strong home record of 19-9, with Miles Mikolas starting, holding a 3.90 ERA.

Royals vs Cardinals Key Information

• Sport: Baseball
• Teams: Kansas City Royals vs. St. Louis Cardinals
• Venue: Busch Stadium in St. Louis, MO
• Date: Wednesday, June 4, 2025
• Betting Odds: Cardinals MoneyLine -129, Royals MoneyLine +109

The Royals Can Win If…

The Kansas City Royals are coming off a 10-7 win over the St. Louis Cardinals. Bobby Witt Jr. led the charge with a home run and four RBIs. Jonathan India also added three hits and scored three runs, providing a strong offensive push.

The Royals’ lineup shows strength in key stats. They rank 8th in doubles and 9th in stolen bases, showing their ability to create scoring chances. With a team batting average of .247, they rank 10th, indicating consistent hitting across the lineup.

On the mound, Noah Cameron will start for the Royals. He has an impressive ERA of 1.05 and a WHIP of 0.82, showing his ability to limit baserunners. Cameron’s strong performance could give the Royals an edge in this game.

The Cardinals Can Win If…

The St. Louis Cardinals are looking to bounce back after their 10-7 loss to the Kansas City Royals. Despite the loss, the Cardinals showed power at the plate with 12 hits and two home runs. Alec Burleson and Nolan Gorman each hit a home run, driving in crucial runs for the team.

St. Louis has a strong batting average of .258, ranking third in the league. Their ability to hit doubles is also impressive, with 109 doubles placing them third. These stats highlight their potential to generate runs and put pressure on opposing pitchers.

Miles Mikolas will start for the Cardinals, bringing a solid 3.90 ERA and a 4-2 record. His experience on the mound can help keep the Royals’ hitters in check. With Mikolas pitching and the team’s batting strength, the Cardinals have a good chance to win this game.

The Lean

The Cardinals are favored with a moneyline of -129 against the Royals at +109. Given the Cardinals’ strong hitting stats, ranking 3rd in batting average and 6th in on-base percentage, they have an edge. My model projects the Cardinals to win 5-3, making the Cardinals a solid pick for the moneyline.

The over/under is set at 8.5 runs. The Cardinals’ pitching has a 3.81 ERA, while the Royals have a 3.13 ERA. Both teams have shown solid pitching, but with the Cardinals’ hitting power, the total score is projected to be 8. This suggests taking the under for this game.

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Royals’ Offensive Reboot

After totaling just 34 home runs and averaging 3.23 runs per game through 60 contests, Kansas City took decisive action to improve its lineup. The club promoted top prospect Jac Caglianone, inserting him into the heart of the order to provide the middle-of-the-order power that had been missing. Despite an 0-for-5 debut in which he was robbed of a would-be double by Cardinals center fielder Victor Scott II, his presence immediately changed the dynamic in the Royals’ clubhouse. Bobby Witt Jr. emphasized that Caglianone’s power potential and intimidating presence at the plate should help everyone in the lineup. For up-to-date MLB picks and expert opinions, fans can visit the Scores and Stats MLB Picks page.

Rookie Lefty Noah Cameron

Kansas City will hand the ball to rookie left-hander Noah Cameron (2-1, 1.05 ERA) in this midweek rematch. In each of his four starts this season, Cameron has worked into the seventh inning, consistently saving the bullpen and keeping the Royals within striking distance. His last outing, a 3-2 win over Cincinnati on May 28, featured 6 ⅓ shutout innings, allowing only six hits and two walks while striking out five. Cameron’s only previous appearance against St. Louis came on May 17, a hard-luck 1-0 loss in which he yielded a Jordan Walker home run but never allowed another run over 6 ⅓ frames. Check out detailed MLB previews for insights on how pitchers like Cameron match up against upcoming opponents.

Cardinals’ Lineup Challenges

With Walker sidelined by a wrist injury, manager Oliver Marmol must reshuffle the Cardinals’ batting order to counter left-handed starters. St. Louis has dropped three of its past four games and faces 28 contests in the next 30 days, testing the depth of its roster. Marmol acknowledged the difficulty of long stretches without a full complement of hitters, but emphasized preparation and resilience as keys to getting through a demanding June slate. Fans looking for advanced strategies and odds analysis can consult the MLB expert betting guide, which offers breakdowns of hitters’ splits and situational performance against southpaws.

Pitching Matchup: Miles Mikolas

The Cardinals will counter with veteran right-hander Miles Mikolas (4-2, 3.90 ERA). After a strong May in which he went 3-0 with a 3.08 ERA, Mikolas stumbled in his most recent start, allowing four runs on nine hits over four innings in a 6-4 win against Baltimore. However, on May 17, he blanked Kansas City over six innings, surrendering just two hits, striking out four, and walking two. In four career starts versus the Royals, Mikolas owns a 3-0 record with a 1.67 ERA. If he can replicate that form, St. Louis will have a prime chance to retake momentum in this three-game set. For those interested in securing expert picks ahead of this matchup, visit the Buy Picks page.

Series Outlook

Kansas City’s ability to build on its 10-7 rally win hinges largely on how quickly Caglianone settles in and whether Cameron can continue to stifle opposing hitters. On the other side, the Cardinals must find alternative run producers without Walker and hope Mikolas can recreate his previous success against the Royals. As the season heats up, it’s also worth tracking which analysts are outperforming the rest—visit the MLB handicappers leaderboard to see who’s leading the way in win-loss records and ROI. Ultimately, Wednesday’s contest will come down to pitching depth and whether Kansas City’s revamped lineup can generate enough runs to support its young southpaw starter.