St. Louis Cardinals vs Milwaukee Brewers Picks and Predictions April 25th 2025

St. Louis Returns Home Seeking Stability

After a rough 1-6 road trip, the St. Louis Cardinals will be looking to reset when they open a three-game series Friday night against the Milwaukee Brewers at Busch Stadium.

The Cardinals (10-15) saw their bullpen crumble repeatedly on the road, with relievers allowing 17 runs (16 earned) across just 12 2/3 innings. With no immediate reinforcements available, manager Oliver Marmol emphasized the need for improvement from within.

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“This is who we’ve got, and we’ve got to get them back on track,” Marmol said. “We’re going to keep going with them. We have to continue to get on the other side of this.”

One positive for St. Louis is its stronger play at home, where the team is 8-4 compared to a dismal 2-11 mark on the road. Left-hander Matthew Liberatore (1-2, 3.60 ERA) will get the start, hoping to build on back-to-back strong outings. Liberatore, embracing a more aggressive approach, has posted three quality starts in four appearances this season and boasts a career 1.02 ERA against the Brewers.

Utility man Brendan Donovan (.356 average) could also return to the lineup after missing two games with a rib injury, providing a much-needed boost to a struggling Cardinals offense.

Brewers Aim to Clean Up Defensive Mistakes

The Milwaukee Brewers (14-11) come in having dropped three of four in San Francisco, with defensive breakdowns playing a major role in the struggles. A closed-door team meeting followed Thursday’s 6-5 loss.

“It wasn’t anything crazy,” Christian Yelich said. “We all know we’ve got to clean it up. In the big leagues, you have to do that. You can’t keep making mistakes.”

The Brewers will turn to rookie right-hander Chad Patrick (1-1, 2.11 ERA), who has impressed early in the season. Patrick has allowed two runs or fewer in each of his four starts but has completed six innings just once. Friday will mark his first career appearance against St. Louis.

Catcher William Contreras, the Brewers’ hottest hitter early this season, is expected back in the lineup after a scheduled day off Thursday.

Both teams are seeking to stabilize after shaky stretches, and Friday’s opener could set the tone for a critical NL Central clash perfect for those keeping an eye on MLB Predictions.