St. Louis Cardinals vs Milwaukee Brewers Picks and Predictions September 19th 2025

St. Louis Cardinals vs Milwaukee Brewers September 19th 2025

The Milwaukee Brewers will visit the St. Louis Cardinals at Busch Stadium on Friday, September 19, 2025. The game will begin at 8:15 PM and will be shown on FDSMW. The Brewers have a strong record of 94-59 and are leading the NL Central. They are on a three-game winning streak and have gone 6-4 in their last 10 games.

The Cardinals, with a 74-79 record, are fourth in the division. They have lost their last game and are 3-7 in their last 10 games. The weather forecast predicts a very hot day with calm winds and overcast clouds. Jacob Misiorowski will start for the Brewers, while Sonny Gray will take the mound for the Cardinals.

Brewers vs Cardinals Key Information

• Sport: Baseball
• Teams: Milwaukee Brewers vs. St. Louis Cardinals
• Venue: Busch Stadium in St. Louis, MO
• Date: Friday, September 19, 2025
• Betting Odds: Brewers Moneyline -118, Cardinals Moneyline +100

The Brewers Can Win If…

The Milwaukee Brewers recently won against the Los Angeles Angels with a score of 5-2. Quinn Priester pitched 5 2/3 innings, allowing only three hits and striking out ten batters. Christian Yelich and Caleb Durbin were key hitters, each contributing to the team’s success with multiple hits and RBIs.

Milwaukee’s batting stats show why they have a strong chance to win. They rank second in the league with a .261 batting average and a .333 on-base percentage. Their ability to get on base and score runs is a big factor in their recent victories.

The Brewers’ pitching staff also stands out, holding a 3.60 ERA, which is second in the league. They have a solid defense, allowing a batting average against of only .229. With Jacob Misiorowski starting, they have a reliable pitcher who can keep the opposing team in check.

The Cardinals Can Win If…

The St. Louis Cardinals are looking to bounce back after a recent 6-2 loss to the Cincinnati Reds. Alec Burleson was a bright spot, hitting a home run and driving in a run. Despite the loss, the Cardinals have shown they can win at home, as seen in their 3-0 victory over the Reds just the day before.

The Cardinals’ lineup features strong hitters like Willson Contreras and Alec Burleson. Contreras leads the team with 20 home runs and 80 RBIs, while Burleson has a .285 batting average. The team ranks 12th in batting average and 13th in doubles, showing their ability to hit consistently and get extra bases.

On the mound, Sonny Gray is set to start, bringing a 13-8 record. Gray’s experience and ability to strike out batters will be key against the Brewers. With a solid lineup and a reliable starting pitcher, the Cardinals have the tools to secure a win in their upcoming game.

The Lean

The Brewers are favored on the moneyline at -118. They have a strong team batting average of .261, ranked 2nd, and an earned run average of 3.60, also ranked 2nd. The Cardinals have a higher ERA of 4.30, ranked 21st, which suggests the Brewers have the edge. My model projects the Brewers to win with a score of 5-3.

The total runs line is set at 7.5. The Brewers’ strong hitting and the Cardinals’ higher ERA suggest more runs could be scored. With my model projecting a total of 8 runs, taking the over at 7.5 (-116) seems reasonable.

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Brewers Battling Injuries Ahead of Postseason

The Milwaukee Brewers enter their weekend series against the St. Louis Cardinals in a very different position than their division rivals. While the Brewers are already locked into postseason contention, they are dealing with a long list of injuries that could impact their October push.

Manager Pat Murphy admitted his team is “beat up badly,” with several pitchers and relievers working through nagging issues. Brandon Woodruff is still working back from a shoulder injury, while Jose Quintana was placed on the 15-day injured list with a calf strain. DL Hall remains sidelined, and Robert Gasser could be added to the bullpen as he finishes his Tommy John recovery.

Closer Trevor Megill’s flexor strain puts his playoff status in doubt, though Rick Mears recently returned from the IL. Despite these challenges, Milwaukee has won five of its last six games, a sign of resilience with the postseason just around the corner.

For Friday’s opener, rookie right-hander Jacob Misiorowski (5-2, 4.35 ERA) gets the nod. He last faced St. Louis on Saturday, giving up four runs in five innings, but the Brewers still won 9-8 in extra innings. Misiorowski is 1-0 with a 3.60 ERA in two career starts against the Cardinals.

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Cardinals Turning Focus Toward 2026

The Cardinals, at 74-79, have fallen out of the postseason race and are shifting their focus toward developing younger talent. They have lost seven of their last nine games and are looking to finish strong while evaluating the future of their roster.

Veteran right-hander Sonny Gray (13-8, 4.43 ERA) will start the series opener. Gray has struggled against Milwaukee this season, posting an 0-1 record with a 6.46 ERA in three starts.

Offensively, St. Louis will be without first baseman Willson Contreras for the remainder of the season due to bicep tightness. Alec Burleson is expected to handle most of the duties at first base, freeing up outfield opportunities for Jordan Walker, who is trying to snap out of a slump.

September has also been difficult for Nolan Gorman (.157 average), rookie Nathan Church (.173), and rookie catcher Jimmy Crooks (.107). Manager Oliver Marmol stressed patience, noting the mix of progress and setbacks his young players are experiencing.

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Key Matchup and Series Outlook

This series opener highlights two pitchers heading in different directions. Misiorowski is trying to earn a postseason role for the Brewers, while Gray is searching for consistency after a season of ups and downs.

The Brewers’ ability to win despite being undermanned will be tested again, while the Cardinals look to see if their younger bats can show promise before the offseason.

Stay updated with the latest MLB picks and game results to follow how both teams perform down the stretch.

Latest Betting Trends

• Milwaukee has won five of its last six games, keeping momentum despite multiple injuries.
• The Brewers are 2-1 against St. Louis over the past week, with both wins coming in close games.
• Sonny Gray has struggled against Milwaukee this season, with a 6.46 ERA in three starts.
• St. Louis has dropped seven of its last nine, with offensive inconsistency from its younger players.
• Milwaukee is 94-59 overall, while St. Louis sits below .500 at 74-79.

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