St. Louis Cardinals vs San Diego Padres Picks and Predictions July 25th 2025

St. Louis Cardinals vs San Diego Padres July 25th 2025

The San Diego Padres will take on the St. Louis Cardinals at Busch Stadium on Friday, July 25, 2025. The game starts at 7:15 PM and will be broadcast on FDSMW. The weather forecast predicts a very hot day with light rain and a light breeze crosswind.

The Padres, led by manager Mike Schildt, have a season record of 55-48. They are 5 games behind in the NL West. Nick Pivetta will start for the Padres with an ERA of 2.81. The Cardinals, managed by Oliver Marmol, hold a 53-51 record and are 9 games back in the NL Central. Miles Mikolas will pitch for the Cardinals, carrying an ERA of 5.20.

Padres vs Cardinals Key Information

• Sport: Baseball
• Teams: San Diego Padres vs. St. Louis Cardinals
• Venue: Busch Stadium in St. Louis, MO
• Date: Friday, July 25, 2025
• Betting Odds: Padres Moneyline -135, Cardinals Moneyline +115, Padres Runline -1.5 (+125), Cardinals Runline +1.5 (-150), Total Over 8.5 (-102), Total Under 8.5 (-120)

The Padres Can Win If…

The San Diego Padres are set to take on the St. Louis Cardinals again after a recent 9-7 loss. Despite the loss, the Padres showed strong batting with 13 hits and two home runs. Manny Machado and Fernando Tatis Jr. each had three hits, with both hitting a home run, showing they are ready to lead the offense.

The Padres’ lineup has some solid stats this season. Manny Machado is hitting .289 with 19 home runs and 63 RBIs, making him a key player. With a team batting average of .246, ranked 11th in the league, their hitters can be a challenge for any pitcher.

On the mound, Nick Pivetta will start for the Padres. Pivetta has a 2.81 ERA and a 10-2 record, showing he can keep the Cardinals’ bats in check. With the Padres’ pitching staff ranked 7th in ERA and 4th in batting average against, they have the tools to secure a win.

The Cardinals Can Win If…

The St. Louis Cardinals are coming off a win against the San Diego Padres, 9-7. Key players like Willson Contreras, Brendan Donovan, and Iván Herrera had strong performances. Contreras drove in four runs with a homer, while Donovan and Herrera also hit home runs, contributing to the team’s total of three homers in the game.

The Cardinals have shown solid hitting stats this season. They rank 6th in batting average at .253 and 3rd in doubles with 184. Their ability to get on base and hit for extra bases could be vital in their next game.

Looking ahead, the Cardinals have a lineup with several players hitting well. Brendan Donovan (.296 AVG) and Iván Herrera (.315 AVG) are key contributors. The team will rely on Miles Mikolas on the mound, hoping he can improve his 5.20 ERA and lead them to another victory.

The Lean

The Padres are favored with a moneyline of -135, while the Cardinals sit at +115. The Padres have a solid pitching staff with a 3.65 ERA, ranking 7th in the league. Given their pitching strength and the Cardinals’ 22nd-ranked ERA of 4.25, the Padres are likely to win. The model projects a score of Padres 5, Cardinals 3.

The total for this game is set at 8.5 runs, with the over at -102 and the under at -120. The Padres’ strong pitching and the Cardinals’ moderate offense, with a batting average of .253, suggest a lower-scoring game. The model’s projected total of 8 runs supports taking the under.

St. Louis Regains Offensive Spark in Wild-Card Push

After a tough post-break slump, the St. Louis Cardinals exploded for a much-needed 9-7 win over the San Diego Padres on Thursday night, snapping a stretch of 13 losses in 18 games. The win pulled the Cardinals within 2.5 games of the Padres for the final National League wild-card spot.

The power display featured home runs from Willson Contreras, Brendan Donovan, and Ivan Herrera, while rookie Victor Scott II showed maturity at the plate with two walks and a stolen base.

“Especially after that road trip, you wanted to come out a little stronger,” said manager Oliver Marmol. “We needed the offense to get going. I liked our approach today — focus, execution, detail — it was all there.”

Cardinals Lean on Bats as Mikolas Struggles

The Cardinals will need to keep the offense rolling as veteran right-hander Miles Mikolas (5-8, 5.20 ERA) takes the mound Friday. Mikolas has struggled of late, allowing five or more runs in three of his last four starts. Still, he holds a solid 3.00 ERA in eight career starts against the Padres — the team that originally brought him to the majors.

St. Louis, sitting on the edge of contention, knows every series counts. The next 10 days will see the Cardinals and Padres face off seven times — a stretch that could swing the wild-card race in either direction.

For fans tracking the race, check the updated MLB standings and wild-card implications daily.

Padres Turn to Red-Hot Pivetta to Halt Skid

The Padres, losers of three straight, will rely on the arm of Nick Pivetta (10-2, 2.81 ERA), who has been nearly untouchable lately. Over his last five starts, he’s allowed only two earned runs across 31.1 innings. Pivetta enters with momentum and a 3.47 ERA in six career starts vs. St. Louis.

“Nick has been outstanding,” manager Mike Shildt told KMOX. “He’s pounding the zone, working quickly — everything you want.”

Pivetta echoed that mindset: “It’s about limiting damage and filling up the zone. If I keep throwing zeros, the wins will come.”

Despite recent injuries to the rotation, the Padres remain firmly in the playoff picture. For betting angles and expert insight, visit the latest MLB picks and previews from Scores and Stats.

Key Stretch Ahead for Both Contenders

This series could help define both teams’ trajectories heading into August. The Cardinals are rediscovering their offensive rhythm, while the Padres need consistency from their pitching staff to remain above the wild-card line. With two high-powered lineups and tight margins, each game promises critical implications in the NL playoff picture.

Let me know if you’d like this article formatted for WordPress or ready for publication in a specific CMS.