Tampa Bay Rays vs Chicago White Sox Picks and Predictions July 22nd 2025

Tampa Bay Rays vs Chicago White Sox MLB Tue, Jul 22, 18:35 pm.
Tampa Bay Rays
ML: -250
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Chicago White Sox
ML: 185
Last Updated on

The Chicago White Sox will travel to face the Tampa Bay Rays at George M. Steinbrenner Field in Tampa, FL. This night game is set for Tuesday, July 22, 2025, at 7:35 PM. Fans can catch the action on FDSSU, with the weather expected to be very hot and overcast.

Chicago holds a record of 36-65 and sits 24 games back in the AL Central. Tampa Bay, with a 52-49 record, is 7 games back in the AL East. The Rays will have Drew Rasmussen on the mound, while the White Sox starter is yet to be announced.

White Sox vs Rays Key Information

  • Sport: Baseball
  • Teams: Chicago White Sox vs. Tampa Bay Rays
  • Venue: George M. Steinbrenner Field, Tampa, FL
  • Date: Tuesday, July 22, 2025
  • Betting Odds: White Sox Moneyline +177, Rays Moneyline -210, White Sox Runline +1.5 (-116), Rays Runline -1.5 (-104), Total Over 8.5 (-104), Total Under 8.5 (-117)

The White Sox Can Win If…

The Chicago White Sox recently won against the Tampa Bay Rays with a score of 8-3. In that game, the team had 11 hits, including 6 extra-base hits and 2 home runs. Sean Burke pitched 4 innings, allowing only 3 hits and no earned runs, while Miguel Vargas and Brooks Baldwin each hit a home run.

The White Sox have shown strong hitting in recent games, with a total of 82 home runs this season. They rank 10th in doubles with 164, showing their ability to get on base and score. Their pitching staff has also been solid, with a team ERA of 4.05 and a batting average against of .249, which ranks 13th in the league.

Key players like Miguel Vargas and Lenyn Sosa have been contributing with both home runs and RBIs. Vargas leads the team with 12 home runs and 40 RBIs, while Sosa has a batting average of .266 and 34 RBIs. With their recent winning streak and strong performances, the White Sox are in a good position to win their next game.

The Rays Can Win If…

The Tampa Bay Rays are looking to bounce back after a tough loss to the Chicago White Sox, 8-3. Despite the loss, Yandy Díaz hit a home run, showing his strength at the plate. Taylor Walls also contributed with a double and two RBIs, highlighting the potential in their lineup.

The Rays have a solid batting average of .257, ranking third in the league. Their on-base percentage is .319, putting them in ninth place. They also lead the league in stolen bases with 130, which can create scoring opportunities.

Drew Rasmussen will start for the Rays, boasting an ERA of 2.86 and a WHIP of 1.03. His performance on the mound can be a game-changer. With the support of top hitters like Junior Caminero and Jonathan Aranda, the Rays have a good chance to secure a win.

The Lean

The Rays are favored to win with a moneyline of -210. The White Sox have struggled offensively, ranking 22nd in batting average and on-base percentage. The Rays have a stronger lineup, ranking 3rd in batting average. My model projects the Rays to win 5-3, making them the recommended pick.

The total for the game is set at 8.5 runs. The White Sox have a lower slugging percentage, ranking 26th, while the Rays have a solid pitching staff with an ERA of 3.80. My model projects a total of 8 runs. Therefore, the recommendation is to take the under 8.5.

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Surging White Sox Look for Fifth Straight Win in Clash vs. Rays

The Chicago White Sox have been a completely different team since the All-Star break. After a hapless first half, the suddenly surging Chicago White Sox will look to win their fifth straight game on Tuesday night as they continue their series against the host Tampa Bay Rays.

The Post-Break Buzzsaw

The White Sox, who had the worst record in the American League in the first half, have come out of the break on fire. They are on a four-game winning streak and have won each of those games by at least five runs. Their offense has been explosive, hitting .353 with runners in scoring position during the streak.

“The focus has been really good, the intensity has been really good and we’ve been doing a great job of picking each other up,” said outfielder Mike Tauchman. “We want to keep it going.”

Rasmussen Unleashed

The Rays will turn to their ace, Drew Rasmussen (7-5, 2.86 ERA), to be the stopper. After being on a strict innings limit before the All-Star break to protect his surgically repaired arm, the team is now easing off the restrictions. This will be a crucial start for Rasmussen to re-establish himself as a true top-of-the-rotation force.

“He always makes it tough because he’s so good,” manager Kevin Cash said of the decision to limit his ace. “But we have to continue to be smart.”

Tampa’s Troubles

While the White Sox are hot, the Rays are dealing with a wave of injuries. They are now without both of their All-Star middle infielders, as Brandon Lowe is out with plantar fasciitis and Ha-Seong Kim left Monday’s game with back tightness. The team’s struggles against sub-.500 opponents have been a perplexing issue, a topic often explored in our expert betting guide. The pitching matchup will be a key focus on the scores and odds board.

For two MLB teams looking to build momentum, this game is crucial. To see if our experts think the White Sox’s surprising streak will continue, check out our daily MLB picks.