Toronto Blue Jays vs Chicago White Sox Picks and Predictions June 21st 2025

Toronto Blue Jays vs Chicago White Sox MLB Sat, Jun 21, 14:07 pm.
Toronto Blue Jays
ML: -222
0
0
Chicago White Sox
ML: 175
Last Updated on

With their eight-game losing streak finally snapped, the Chicago White Sox head into Saturday afternoon’s rematch against the Toronto Blue Jays riding a wave of confidence. After dropping both ends of a Thursday doubleheader in St. Louis, Chicago erupted for seven first-three-inning runs in Friday’s 7-1 victory in Toronto. That early offensive assault not only turned the tide for the club but also shifted the betting market—if you’re looking for angle-based plays, see our latest MLB picks for recommended lines and props.

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Saturday’s pitching matchup: Berríos vs. Civale

Toronto plans to send José Berríos to the mound, a veteran right-hander who has posted a 2-3 record and 3.81 ERA this season. Against the White Sox, however, he owns a sterling 14-6 ledger with a 3.16 ERA over 25 career starts. Berríos generates ground balls at a 49 percent clip and whiffs 8.6 batters per nine innings, making him particularly tough on free-swinging lineups early on.

Chicago counters with Aaron Civale, making his second start since arriving from Milwaukee. Civale struggled through 4⅔ innings in his White Sox debut but showed a heavy sinker that induced 13 grounders. Over five career outings versus Toronto, he’s 2-3 with a 5.11 ERA. Bettors who lean on first-five-innings props or low-scoring forecasts should dive into our detailed MLB previews for splits on early-inning run totals and K/BB ratios.

Bullpen strategies under the microscope

Both teams leaned on opening pitchers in Friday’s opener, underscoring the increasing importance of multi-inning relievers. Toronto began with Spencer Turnbull, who totaled just 45 pitches and surrendered four runs over two-plus innings. The club cycled through seven bullpen arms, a usage pattern that can tilt over/under outcomes; our MLB betting guide highlights how inherited runners scored and bullpen ERA trends inform your total-run forecasts.

Chicago, forced into a bullpen game after Davis Martin hit the injured list, opened with Grant Taylor (perfect first inning) before Tyler Alexander held Toronto scoreless over four frames. That five-pitcher mix helped preserve their bullpen depth but raises questions about durability if Saturday’s contest tightens late. Bettors tracking live in-game run lines may find value if either manager turns to a fresh arm in high-leverage spots.

Roster moves shape the finale

Injuries and promotions have reshaped both bullpens this weekend. The White Sox placed Cam Booser on the 15-day injured list (left shoulder) and promoted Wikelman Gonzalez and Jacob Palisch. Gonzalez, 5-0 with a 2.75 ERA in Triple-A Charlotte, debuted Friday with two innings of one-run ball. Palisch, with a 1.19 ERA over 15 Double-A outings, provides another high-leverage option.

Toronto reinstated Nathan Lukes (concussion) and Nick Sandlin (lat strain) from the injured list, bolstering both bench depth and late-inning matchups. Lukes went 1-for-4 as the opener’s left fielder, and Sandlin worked a clean sixth inning. The Bay Street club optioned Justin Bruihl and Will Robertson to Triple-A, reflecting a “win-now” bullpen build. If you want to see who’s outperforming the market, take a look at our leaderboard of top handicappers.

Betting outlook and strategy

Saturday’s line is expected to open around a 1.5-run spread in favor of the Jays, with an over/under near 8.5. Chicago’s offense has been explosive early, while Toronto’s bullpen depth is a question mark. If Berríos works efficiently but the lineup can’t capitalize, there’s value in a Sox moneyline live play or under 4.5 runs through five innings. Conversely, if you believe Toronto’s starters will bounce back, a Jays moneyline parlay with props on Berríos’s strikeout totals could pay dividends.

Whenever you’re ready to lock in your wagers, you can buy picks from our analysts for targeted recommendations. Whether you’re trading the run line, chasing props, or playing live in-game, weighing starter durability, bullpen usage, and roster depth will be key to closing out this series.

By T. Franklin Smith | April 8, 2025
By T. Franklin Smith | April 1, 2025
spread
moneyline
over/under
Toronto Blue Jays
-
-
-222
O 8.5
-125
Chicago White Sox
-
-
175
U 8.5
100
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Mike Williams
Mike Williams | Handicapper

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Mike uses his strong sports knowledge to analyze all the angles to find the most profitable wagers. Iron Mike handicaps MLB, college football, NFL, NBA, and NCAA basketball. I'm an actual sports and gambling junkie!

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