Washington Nationals vs Chicago White Sox Picks and Predictions September 27th 2025

Chicago White Sox vs Washington Nationals Betting Preview

The Chicago White Sox and Washington Nationals meet again Saturday after a wild slugfest opened their series at Nationals Park. Chicago (59-101) snapped a five-game skid with a 10-9 win, while Washington (65-95) watched Luis García Jr.’s historic three-homer performance spoiled by a ninth-inning error and Colson Montgomery’s go-ahead blast. With both teams long eliminated from contention, this matchup is about closing the season strong. Recent MLB game results show both clubs have been scuffling, but the opener proved their lineups are still dangerous.

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Sean Burke (4-11, 4.29 ERA) starts for Chicago, still seeking his first win since June. Washington counters with Jake Irvin (9-13, 5.69 ERA), who snapped a long personal skid last weekend but remains inconsistent.

Line Movement and Odds

• Moneyline: White Sox +101 | Nationals -120
• Total (O/U 8.5 runs): Over -110 | Under -110

After Friday’s slugfest, bettors pushed the total up to 8.5, with early action leaning Over. Washington opened a slight favorite behind Irvin’s recent win.

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Matchup Breakdown

White Sox Outlook

Chicago erupted for 10 runs Friday behind Lenyn Sosa (3-for-4, HR, 3 RBI) and Montgomery’s clutch ninth-inning homer. Sosa now leads the team with 22 home runs, while Montgomery has hit safely in eight straight games. Despite ranking just 18th in MLB in total homers (160), the White Sox have shown they can punish mistakes when locked in.

Sean Burke will take the mound, still winless since June 25. He’s 0-1 with a 4.38 ERA across three starts since returning from Triple-A. Burke allowed three runs in four innings last time out and has struggled with command in key spots.

Nationals Outlook

Washington nearly pulled off a stunning comeback Friday behind García Jr.’s three homers and Daylen Lile’s game-tying shot in the eighth. Lile has been red-hot since late July, hitting .345 with 25 extra-base hits over that span. The Nationals’ power showed up Friday with six long balls, though consistency has been an issue all season.

Jake Irvin has been shaky down the stretch (1-8, 8.37 ERA in his last 10 starts), but he earned a much-needed win last week over the Mets. Washington will need him to limit damage early after their bullpen was taxed heavily Friday night.

Key Battle

Burke vs. the long ball. The Nationals just slugged six home runs in the opener, while Burke has been prone to mistakes over the plate. If Washington’s hitters jump on him early, Chicago could be forced into another bullpen game.

Injuries and Conditions

Weather: Overcast with mild temps in the low 70s. Conditions should favor hitters again.

Best Bets and Prediction

Expect another high-scoring affair with two struggling starters and bullpens that just got tested in Friday’s slugfest. Washington’s lineup looks more balanced right now, but Chicago’s young bats are swinging with confidence.

• Pick: Nationals ML -120
• Projected Score: Nationals 5, White Sox 4
• Total Lean: Over 8.5 (-110)

Handicappers and Picks

This matchup may not carry playoff implications, but it still offers value on the board. Late-season games like these can swing heavily on motivation, lineup health, and bullpen usage — factors our experts weigh daily.

Check the Leaderboard to see which handicappers are heating up in MLB’s final stretch. For premium, fully documented selections, head to the Service Plays hub. Free picks and projections for every matchup can also be found on the MLB Picks page.

For more guidance on betting late-season matchups where both teams are eliminated, the Bettors Handbook provides strategies for identifying value in games where motivation is questionable.

SAS has you covered with insights, angles, and picks to close out the season.