Washington Nationals vs St. Louis Cardinals Picks and Predictions May 10th 2025

Red-Hot Cardinals Target Seventh Straight Win Against Slumping Nationals

The St. Louis Cardinals are riding high and showing no signs of slowing down. After a dominant 10-0 win over the Washington Nationals on Friday, the surging Cards will look to secure a series victory and extend their winning streak to seven games—their longest since 2022—when the teams meet again Saturday afternoon.

Pitching Dominance Fuels Cardinals’ Streak

Friday’s blowout featured a six-hit shutout from former Nationals pitcher Erick Fedde, who dismantled Washington’s lineup with precision and poise. It continued a dominant stretch from the Cardinals’ rotation, which has now allowed just one run over its last 23 innings.

Winning Picks, Expert Advice—Follow The Best Handicappers Now!

“We just saw him do something special… he had everything working.”
— Oliver Marmol, Cardinals Manager

With a 17-1 run differential over their last three games, St. Louis has found the kind of balance—between elite starting pitching and timely offense—that makes them one of the hottest teams to back in MLB picks and predictions right now.

Pallante Aims to Keep Momentum Alive

Right-hander Andre Pallante (2-2, 4.75 ERA) gets the ball for the Cardinals on Saturday. Though he’s gone four straight starts without a win, St. Louis has remained competitive behind him, including a 5-4 victory over the Mets in his last outing.

Pallante owns a 1-1 career record and a 7.36 ERA in five appearances against the Nationals. He’ll need to find better rhythm if the Cardinals want to keep the streak alive—and bettors watching MLB betting matchups will be eyeing how he handles Washington’s left-leaning lineup.

Nationals Searching for Answers

For Washington, the loss was their third straight and one of their most deflating of the season. Starter Mitchell Parker struggled early, and the bullpen couldn’t stop the bleeding. The Nats have now surrendered 27 runs over their last three games, and their team ERA (5.47) is third-worst in the majors.

Win Big With MLB Picks Backed By Real Momentum

Join the Experts and Start Winning Today!

Start Now!

Gear up for the game—your go-to spot for MLB Scores and Odds.

“This one wasn’t good… I’m sitting here trying to figure out what went wrong.”
— Davey Martinez, Nationals Manager

Veteran Trevor Williams (2-3, 5.86 ERA) will start Saturday, hoping to deliver some stability. He’s coming off a win against Cincinnati but has yet to complete six innings in any start this season. Against the Cardinals in his career, he’s 5-6 with a 4.93 ERA across 22 appearances.

With the way the Cards are swinging the bats, Williams will have his hands full—especially if St. Louis continues to apply early pressure.