Philadelphia-76ers vs Los Angeles Lakers Picks and Predictions December 7th 2025

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Match Facts

MatchupDetail
TeamsLos Angeles Lakers at Philadelphia 76ers
DateSunday (regular-season matchup)
VenuePhiladelphia
Schedule spotLakers close out an East Coast road trip; Sixers return home after a statement win vs Milwaukee
Recent formLakers split first two on the trip (win at Toronto, loss at Boston); Sixers on a three-game winning streak
Season seriesTeams split their 2024-25 meetings so far; Lakers have lost seven straight in Philadelphia

Line and Odds

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MarketNumberNotes
SpreadSixers favored by a few points at homeRest edge and home court push the number toward Philadelphia, but injuries on both sides keep it reasonable.
TotalHigh 220s to low 230sDepends heavily on Embiid and Luka status; both can swing pace and efficiency.
MoneylineSixers home favoriteLakers’ injuries and road spot vs Sixers’ three-game win streak at home.
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Line Movement Matchup

This is a tricky number for the market because both teams have major game-time questions. The Lakers are dealing with LeBron James’ back/foot issue and Luka Doncic’s absence for personal reasons, while the 76ers have Joel Embiid listed as questionable with a knee problem. Any firm news on those three will move the spread and total.

Los Angeles split the first two games of this trip in wildly different fashion. Without Doncic, the Lakers stole a 123-120 win in Toronto on a Rui Hachimura buzzer-beating three. The next night in Boston, they were run off the floor early, outscored 39-17 in the first quarter and never recovered in a 126-105 loss. That kind of volatility is what keeps oddsmakers from drifting too far in either direction.

Philadelphia has the cleaner profile right now, riding a three-game win streak and coming off a 116-101 win over Milwaukee where Embiid sat, Tyrese Maxey struggled by his standards and Paul George still carried them with his best outing of the season. For bettors, this matchup sits right in the wheelhouse of short home-favorite decisions you usually see dissected on the main NBA picks slate.

Breakdown Injury Reports

Los Angeles Lakers injury report

PlayerStatusNote
Luka DoncicOut recently (personal) / expected back “soon”Missed first two games of the trip after the birth of his daughter; return timing dictates the ceiling of this offense.
LeBron JamesQuestionable (back/left foot)Sat in Boston after an eight-point game in Toronto ended his double-digit streak; his availability changes everything in the halfcourt.
Austin ReavesActive, heavy workloadHas scored 80 points in the first two games of the trip with elite efficiency; carrying a huge offensive load.
Other rotation piecesDay-to-day bumps onlyRole players like Hachimura and LaRavia are filling larger roles with stars out.

Philadelphia 76ers injury report

PlayerStatusNote
Joel EmbiidQuestionable (knee)Sat vs Bucks; status will heavily impact spread and total.
Tyrese MaxeyActiveCame in under his scoring average vs Milwaukee but remains one of the league’s top scorers.
Paul GeorgeBack from knee/ankle issuesLimited to seven games this season but just had his best performance of the year.
Other startersManaging minor knocksSeveral key pieces have missed time already; depth will be tested if Embiid sits again.

Los Angeles Lakers recent performance

This road trip has shown both the upside and fragility of the current Lakers build. The high point came in Toronto, where they overcame Doncic’s absence and James’ worst scoring outing in nearly two decades by getting a Hachimura three at the buzzer to win 123-120. The low point was the next night in Boston, where a lethargic, shorthanded group fell behind 39-17 in the first quarter and never seriously threatened.

James is officially questionable after the back/foot issues that kept him out in Boston and limited him to eight points in Toronto, ending his historic run of consecutive double-digit scoring games. Doncic has not played on this trip while tending to personal matters and celebrating the birth of his daughter. Redick insists he will be back “soon,” but until he returns, the offensive creation burden falls heavily on Austin Reaves.

Reaves has responded with star-level production: 80 points in two games, 22-of-39 from the field, over 42 percent from three and 28-of-32 at the line. The efficiency is real, not just empty volume, and it has kept the Lakers competitive despite missing their two alpha options. LaRavia acknowledged the group came out flat in Boston, but he also shouldered responsibility, noting that the starting unit has to bring energy regardless of travel or fatigue. That mentality needs to show up early in Philadelphia to avoid another big first-quarter hole.

Philadelphia 76ers recent performance

The Sixers are stacking wins even while juggling injuries. They have won three straight and are one off their season-best streak following the 116-101 victory over Milwaukee. That result was encouraging because it came without Embiid, with Maxey well below his standard, and with George taking a star turn just as the team needed another high-end option.

George delivered 20 points, five rebounds, five assists and no turnovers, and afterward said he finally “felt like myself again.” Maxey appreciated the support, pointing out how hard George has worked to get back and how important it is to have that kind of two-way presence on the floor. Even with just 12 points on 5-of-14 shooting, Maxey’s ability to coexist as a primary or secondary option makes this offense flexible.

The big question is Embiid’s knee. He’s listed as questionable, and his presence not only changes the scoring and rebounding math but also affects how opposing defenses are forced to guard. With Embiid on the floor, Maxey’s life gets easier and George can pick his spots. Without him, the Sixers lean more heavily on spacing, pace and guard play, relying on balance over brute force. Either version is dangerous, but the ceiling is clearly higher when the MVP candidate suits up, which is exactly why his status always looms large in discussions around NBA MVP odds.

A lot of this handicap comes down to who is actually in uniform. If even two of the four headliners (James, Doncic, Embiid, Maxey at full strength) are missing or limited, the game tilts hard toward depth, coaching and role-player performance. That naturally favors a Sixers team that just proved it can beat a contender like Milwaukee without Embiid at full power.

From the Lakers’ side, the Reaves explosion is a positive, but you cannot count on 40-point nights and near-perfect free-throw shooting every game. Los Angeles has to tighten its starts, protect the ball and generate more consistent looks in the halfcourt. Whoever plays between James and Doncic will dictate whether the Lakers look like a high-variance live dog or just a tired team trying to get home healthy.

Philadelphia’s rhythm, three-game win streak and home-court track record make them the more stable side. With George moving better and Maxey scoring at an elite clip, they can attack the Lakers’ defense off the dribble and on the perimeter even if Embiid remains limited. This is exactly the kind of spot where applying concepts from the NBA betting guide—injury clusters, schedule spots and star-dependence—helps you avoid reactive, headline-driven bets.

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Best Bets and Prediction

Projected final score: 76ers 117, Lakers 110

Assuming at least one of James or Doncic returns but Embiid plays limited minutes or sits, the most likely script is a competitive, offense-driven game where the Sixers’ depth and home-court energy carry them late. The Lakers can hang for stretches on the back of Reaves, spot shooting and whatever their available star gives them, but sustaining that for 48 minutes against a rested, confident Sixers team is a big ask at the end of a trip.

If all of Embiid, George, Maxey and one Lakers star are active, the total leans upward and the Sixers still hold a slight edge because of continuity and defensive versatility. Either way, a mid-to-high 110s result for Philly with the Lakers trailing by a couple of possessions most of the fourth quarter fits both profiles.

Handicapper section

This matchup is about managing volatility. The Sixers are the more stable side: three wins in a row, a home game, multiple scoring options and a defense that can adjust to whichever version of the Lakers shows up. The injuries are real, but their system has already proven it can absorb some load and still beat top-level competition.

The Lakers are almost entirely tied to star availability and Reaves’ continued surge. As a result, they are best treated as a price-driven underdog: interesting if the line balloons due to public overreaction to the Boston blowout or early injury news, but not a team you want to back blindly in a tough building.

In a full NBA slate, this game fits best as a spot you scale into after confirmed lineups, not a pre-lineup anchor. When the numbers are locked in, weigh the side and total using your view on how many possessions it takes before the Lakers’ fatigue and injury issues show up, and lean on the live NBA scores and odds board to ensure you are getting the right price for the risk.

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