Depaul Blue Demons vs Uconn Huskies Picks and Predictions December 21st 2025

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The Connecticut Huskies enter 11-1 and ranked No. 5 nationally, while the DePaul Blue Demons aim to defend their home court after a strong start. Bettors will weigh UConn’s dominance against DePaul’s resilience in this Big East matchup at Wintrust Arena.

Line Movement and Odds

UConn opened as a double-digit favorite, with the line reflecting confidence in their recent form. Current market:

  • Connecticut Spread: -14.5 (-110)
  • DePaul Spread: +14.5 (-110)
  • Connecticut MoneyLine: -1500
  • DePaul MoneyLine: +850
  • Total: 136.5 (-110)

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Matchup Breakdown

DePaul Outlook

DePaul averages 76.4 points per game, with CJ Gunn and Kaleb Banks leading the offense. Their free-throw attempts (24.3 per game) highlight aggressiveness, while their 7-3 home record underscores competitiveness. Their 3-1 ATS mark as underdogs suggests betting value, though their 8-4 overall record reflects inconsistency.

UConn Outlook

UConn averages 79 points per game with Solo Ball and Silas Demary Jr. providing scoring depth. Their shooting efficiency (49.7% FG, 36th nationally) and rebounding edge (47-29 vs Butler) highlight dominance. Their 11-1 record and perfect 3-0 away mark underscore betting confidence heading into Big East play.

Key Matchup / Path to Victory

The game hinges on UConn’s ability to maintain offensive rhythm, while DePaul must lean on Banks and Gunn to pace the offense. If UConn controls tempo and boards, their depth should create separation.

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UConn Huskies
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Injuries / Availability

DePaul: No confirmed injury updates available. You can check each team’s injury report for the latest status.

UConn: No confirmed injury updates available. You can check each team’s injury report for the latest status.

Environment

Wintrust Arena provides DePaul with a strong home-court edge, where they are 7-3 this season. UConn’s 3-0 road record highlights their ability to perform away from home.

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Best Bets and Prediction

Projected Final Score: Connecticut 79, DePaul 70

  • DePaul +14.5 → Best Bet. Their scoring pace and home-court edge make them a strong cover candidate.
  • Over 136.5 → Total play. Both teams’ scoring averages point toward a combined score above the line.

UConn’s depth and shooting should dictate the game, but DePaul’s offense keeps the spread in play. Expect a competitive contest trending over the total.

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