Michigan State Spartans vs Duke Blue Devils Picks and Predictions December 6th 2025

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The Michigan State Spartans host the Duke Blue Devils in East Lansing for a clash of undefeated top-10 programs. No. 7 Michigan State (8-0) and No. 4 Duke (9-0) bring elite talent and momentum into this marquee matchup. Bettors must weigh Duke’s defensive toughness against Michigan State’s rebounding and depth.

Line Movement and Odds

  • Michigan State Spartans Spread: -1.5 (-110)
  • Duke Blue Devils Spread: +1.5 (-110)
  • Michigan State Spartans MoneyLine: -125
  • Duke Blue Devils MoneyLine: +105
  • Total: 143.5 (Over -110, Under -110)

Michigan State opened as slight favorites at home. See full NCAA Basketball odds for market movement.

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Matchup Breakdown

Duke Blue Devils Outlook

Duke survived Florida 67-66 for its ninth straight win. Freshman Cameron Boozer has scored 20+ points in five games, while Jon Scheyer’s team has held seven opponents under 40% shooting. The Blue Devils average 76 points per game and rely on Boozer’s scoring and defensive consistency. Their ability to grind out close wins shows resilience, but facing Michigan State’s rebounding will be a major test.

Michigan State Spartans Outlook

Michigan State defeated Iowa 71-52 with a dominant 37-18 rebounding edge. Jaxon Kohler has four double-doubles, while Jeremy Fears Jr. leads in assists. The Spartans average 78 points per game and have beaten ranked opponents Arkansas, Kentucky, and North Carolina. Tom Izzo’s squad thrives on depth, free-throw efficiency (22 of 25 vs Iowa), and defensive toughness at home.

Key Matchup / Path to Victory

Duke’s perimeter defense vs Michigan State’s rebounding and depth. The Blue Devils must rely on Boozer’s scoring and defensive stops, while the Spartans need Kohler and Fears to control the boards and pace. The Breslin Center atmosphere adds to Michigan State’s edge.

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Injuries / Availability

Duke: No major injuries reported, Boozer continues to lead the offense.
Michigan State: Full roster available, with Kohler and Fears anchoring the lineup.

  • Duke is 9-0 overall, with two wins over ranked SEC opponents.
  • Duke has held seven opponents under 40% shooting.
  • Michigan State is 8-0 overall, with wins over Arkansas, Kentucky, and North Carolina.
  • Michigan State is 116-16 in December home games under Tom Izzo.
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Best Bets and Prediction

Projected Final Score: Michigan State 75, Duke 72

  • Michigan State -1.5 (-110) → Best Bet. Spartans’ rebounding and home-court edge suggest they cover.
  • Over 143.5 (-110) → Total. Both teams average over 75 points, leaning over in a high-paced showdown.

Michigan State’s depth and rebounding should secure the win, while Duke’s defense keeps it close. Expect a competitive, high-scoring game trending over the total.

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