Purdue Boilermakers vs Eastern Illinois Panthers Picks and Predictions November 28th 2025

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No. 1 Purdue returns home Friday after dominating Texas Tech 86-56 to win the Baha Mar title. The Boilermakers enter at 6-0 and have looked like the most complete team in the country through two weeks. Their defensive improvement and rebounding margin have impressed Matt Painter as they head toward their Big Ten opener. For real-time movement, check the updated NCAA basketball odds.

Eastern Illinois visits West Lafayette at 2-4 with tough road losses to Notre Dame, Valparaiso, Central Arkansas and then-No. 9 Kentucky. The Panthers have not faced a No. 1 team in program history, and this matchup becomes another steep test in a difficult nonconference slate. They get senior guard Zion Fruster back from injury, and he responded with 21 points in Tuesday’s loss.

Purdue has dropped only one November game since 2021. Seven players hit double figures last week, and Oscar Cluff continues to stabilize the frontcourt with 12 points and 11 rebounds per game. The Boilermakers score 86.5 points per game and hold opponents to 69, a combination that makes them one of the most balanced teams in the country.

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Line Movement and Odds

Oddsmakers will price Purdue as a heavy home favorite with a large spread, while Eastern Illinois projects as one of the biggest underdogs of the week. Purdue’s scoring depth and size often inflate totals, though early support typically leans on their defensive consistency. For broader comparisons across Friday’s board, visit the college basketball previews section.

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Matchup Breakdown

Purdue controls games with rebounding, shot selection and pace discipline. Cluff’s emergence adds interior versatility, and Fletcher Loyer’s 16.3 points per game keep their half-court offense efficient. Painter continues to emphasize defensive rotations and limiting slippage as games progress.

Eastern Illinois averages only 60.2 points per game and struggles to maintain pace with high-possession teams. Fruster’s return gives the Panthers needed scoring, but they rely heavily on perimeter creation. Kooper Jacobi and Terry McMorris provide secondary scoring, yet the Panthers face a major size and depth gap in nearly every rotation.

The mismatch inside and Purdue’s physicality should dictate tempo immediately. For additional angles and supporting models, see the free NCAAB picks hub.

Injuries and Conditions

Purdue

  • Liam Murphy (shoulder) – Questionable, trending upward
    Full player info: Purdue team page

Eastern Illinois

No new injuries reported.
Full player info: Eastern Illinois page

Indoor matchup, no weather considerations.

Best Bets and Prediction

Purdue dominates the glass, controls pace and overwhelms weaker defenses with depth. Eastern Illinois’ scoring limitations make it difficult to keep the spread competitive.

Projected Score: Purdue 88, Eastern Illinois 52
Best Bet: Purdue −large spread (up to −29.5 playable)
Secondary Lean: Under, tied to Eastern Illinois’ offensive ceiling

For bankroll planning and structured betting frameworks, review the Bettors Handbook.

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