Saint Louis Billikens vs Stanford Cardinal Picks and Predictions November 28th 2025

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Stanford and Saint Louis meet Friday night in Palm Springs for the Acrisure Invitational championship. The Cardinal improved to 5-1 after a 72-68 win over Minnesota behind freshman guard Ebuka Okorie, who continues to drive the team’s scoring load. Kyle Smith praised his young star for handling pressure well, though he’s looking for more rotation support as Stanford faces its toughest test of the season. For updated pricing, check the NCAA basketball odds page.

Saint Louis arrives unbeaten at 6-0 after edging Santa Clara 71-70. Trey Green drilled six threes and scored 21 points, and Kellen Thames delivered the decisive layup in the final seconds. The Billikens have been one of the most efficient offensive teams in the country, and their pace-shooting combo has overwhelmed every opponent so far.

This matchup gives Stanford’s freshman-led backcourt another high-level defensive look, while Saint Louis gets its first neutral-site challenge of the season.

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Line Movement and Odds

Saint Louis opened −4.5 with a total near 158.5. Early action has split between the side and the total, with bettors showing respect for the Billikens’ scoring profile and Stanford’s ability to control tempo through free throws and rim pressure. For comparisons across Friday’s board, visit the college basketball previews section.

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Matchup Breakdown

Stanford’s path revolves around Okorie, who has scored 25, 17 and 26 in recent outings. Their pace and ability to draw fouls keep them competitive in fast games. Benny Gealer continues to facilitate, and the Cardinal rebound well enough to maintain possessions. The question is whether they can defend the perimeter against elite spacing.

Saint Louis brings much more scoring depth. They average 95.6 points per game and shoot nearly 53 percent from the field. Green gives the Billikens a high-volume threat from deep, while their supporting guards attack downhill. Their size and efficiency create one of the rare mid-major offenses that can sustain 40 minutes of pressure.

For projections across similar spreads, check the free NCAAB picks page.

Injuries and Conditions

Stanford

No new injury updates.
Full roster: Stanford team page

Saint Louis

No new injuries reported.
Full roster: Saint Louis team page

Neutral-site indoor environment, no weather impact.

Best Bets and Prediction

Stanford has improved defensively, but Saint Louis brings too much scoring depth for extended stretches. The Billikens’ perimeter accuracy and balanced rotation tilt the matchup.

Projected Score: Saint Louis 82, Stanford 74
Best Bet: Saint Louis −4.5
Secondary Lean: Under 158.5

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