Chicago White Sox vs Minnesota Twins Picks and Predictions August 22nd 2025

Chicago White Sox vs Minnesota Twins August 22nd 2025

The Minnesota Twins will visit the Chicago White Sox at Rate Field on Friday, August 22, 2025. The Twins hold a record of 58-69 and are ranked 4th in the AL Central. They are on a three-game losing streak and have struggled in their last 10 games with a 2-8 record.

The Chicago White Sox have a record of 45-82, placing them 5th in the AL Central. They are currently on a two-game losing streak and have a 3-7 record in their last 10 games. The game will be played under clear skies, with warm temperatures and a light breeze.

Twins vs White Sox Key Information

• Sport: Baseball
• Teams: Minnesota Twins vs. Chicago White Sox
• Venue: Rate Field in Chicago, IL
• Date: Friday, August 22, 2025
• Betting Odds: Twins Moneyline -138, White Sox Moneyline +117

The Twins Can Win If…

The Minnesota Twins are looking to bounce back after their recent game against the Athletics, where they lost 8-3. Despite the loss, Austin Martin and Royce Lewis each contributed with an RBI. Brooks Lee, although hitless, managed to score a run, showing the potential for future impact.

The Twins have shown they can deliver power at the plate, ranking 13th in home runs with 146 this season. Their lineup features Byron Buxton, who has hit 25 home runs and has a .270 batting average. With players like Brooks Lee and Matt Wallner contributing in key moments, the Twins have the capability to put runs on the board.

On the mound, Zebby Matthews will start for the Twins, entering the game with a 5.06 ERA. While his numbers suggest room for improvement, Matthews has the ability to keep games close. The Twins’ bullpen has been reliable, with only 18 blown saves, ranked 6th in the league, which can be crucial in tight contests.

The White Sox Can Win If…

The Chicago White Sox are looking to bounce back after a narrow 1-0 loss to the Atlanta Braves. In that game, Martín Pérez delivered a strong performance, pitching 5 1/3 innings and allowing no earned runs. Despite the loss, the White Sox showed solid defense, matching the Braves with four hits.

Key stats show the White Sox have a chance to win with their power hitting. They have hit 125 home runs this season, ranking 20th in the league. Lenyn Sosa, with 17 home runs, leads the team and can make a big impact in the game.

Starting pitcher Aaron Civale will take the mound for the White Sox. He has a 4.88 ERA and a 1.35 WHIP this season. Against the Twins’ starter Zebby Matthews, who has a 5.06 ERA, Civale could give the White Sox an edge in this game.

The Lean

The Twins are favored with a moneyline of -138 against the White Sox at +117. The Twins have a slightly better pitching and hitting rank compared to the White Sox. My model projects the Twins to win with a score of 5-4. Based on these factors, the recommendation is to pick the Twins to win straight up.

The total for the game is set at 8.5 runs. Both teams have mid-tier pitching and hitting stats, which suggests a moderate scoring game. My model projects a total score of 9 runs. Therefore, the recommendation is to take the over at 8.5 (-104).

Score a Homerun!

With our Premium Handicapping Membership

Get Free Trial

White Sox, Twins Clash as Both Aim to Stop the Bleeding

The Chicago White Sox and Minnesota Twins are both in desperate need of a turnaround as they meet Friday to open a three-game series at Guaranteed Rate Field. Chicago has dropped six of its last seven games and 13 of 16 overall following a brief surge to open the second half of the season.

The Twins, meanwhile, limp into the matchup after a 1-6 homestand capped by an 8-3 loss to the Oakland Athletics. Both teams hope that this head-to-head series can serve as a much-needed reset in their respective seasons.

For those tracking betting opportunities during MLB’s mid-August slate, make sure to review the latest expert MLB picks

Montgomery and the Rookies Show Growing Pains

Chicago’s roster looks notably different since the teams last met on April 24, when the White Sox shut out the Twins 3-0 in a rain-shortened, seven-inning game. A wave of rookies has taken over key roles, headlined by shortstop Colson Montgomery.

Montgomery, however, is currently mired in a slump. Since hitting his 10th home run on August 11, he has gone just 3-for-27 (.111) with nine strikeouts. After resting Tuesday due to left side soreness, he returned Wednesday and went 0-for-3 in a 1-0 loss to the Atlanta Braves.

Despite the downturn, Montgomery is embracing the experience, noting that both the highs and lows will contribute to his development. White Sox fans hoping to see if the team can capitalize on their youth movement should stay current with each MLB preview

Twins Searching for Answers on Both Sides of the Ball

The Twins’ issues run deeper than just bad luck. During their loss to Oakland on Thursday, they managed just five hits. Royce Lewis added a ninth-inning RBI double but went 3-for-22 during the homestand. Brooks Lee’s streak of six straight games with an extra-base hit came to an end as well.

Manager Rocco Baldelli acknowledged his team didn’t execute in any phase of the game. However, he emphasized staying focused, preparing the right way, and maintaining a strong attitude despite the slump.

For bettors and analysts tracking how slumping teams respond, visit the MLB expert betting guide to see how oddsmakers and cappers are projecting upcoming performances.

Pitching Matchup: Zebby Matthews vs. Aaron Civale

Right-hander Zebby Matthews (3-4, 5.06 ERA) will take the mound for the Twins. The rookie, who was called up in May, will be facing the White Sox for the first time in his career. In his last outing against Detroit, Matthews allowed two runs over four innings while striking out six and walking a career-high four batters.

Matthews admitted to struggling with command, pointing to arm-side misses and potential mechanical issues.

The White Sox counter with veteran right-hander Aaron Civale (3-8, 4.88 ERA), who was acquired from Milwaukee in June. Civale has had a rough August, posting a 6.89 ERA in three starts, but showed signs of stability in his most recent outing, tossing six innings of three-run ball against Kansas City.

In his career against Minnesota, Civale owns a 1-4 record with a 4.34 ERA across 11 starts. Those reviewing starter-vs-team trends can benefit from checking out MLB game results to track past matchups.

Betting Angles and Handicapping Perspective

With both teams in a slump and inconsistent pitching on display, this series may offer betting value for those looking to back totals or team-specific props. Whether you’re leaning on the bounce-back potential of Civale or backing young talent like Matthews, the betting angles are wide open.

For premium picks and insights from elite cappers, explore the buy picks section Also, be sure to follow the best-performing handicappers to guide your decisions during this critical series.