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Preview: Bills at Cardinals

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The magic ran out for the Arizona Cardinals when they suffered their first loss of the season last week, but they have a prime opportunity to get back on track when the struggling Buffalo Bills visit the desert Sunday afternoon. The Cardinals rode an opportunistic defense and a good bit of luck to a 4-0 start before last week's 17-3 loss at St. Louis. They'll try to rebound and preserve at least a share of the NFC West lead against a Bills team that allowed San Francisco a franchise-record 621 total yards in last week's 45-3 loss.

The Bills' defense has been their downfall - they've allowed 145 points in their three losses and 31 in their two victories - but the offense was nearly as dismal against the 49ers in managing just 204 total yards. Buffalo is far from being out of the playoff picture and is just a game back in the tight AFC East standings. The Bills have won four of the past five meetings, but Arizona won the most recent contest 41-17 at home in 2008.

TV: 4:05 p.m. ET, CBS. LINE: Cardinals -4.5, O/U 43.5

ABOUT THE BILLS (2-3): Buffalo has shown flashes of brilliance on offense - quarterback Ryan Fitzpatrick is tied for the AFC lead with 12 touchdown passes and C.J. Spiller has been electric out of the backfield - but they've also committed 13 turnovers. And the defense has been dreadful, ranking 31st in the league in total yards and scoring. High-priced free agent defensive end Mario Williams has been a major bust with just 11 tackles and 1 1/2 sacks through five games.

ABOUT THE CARDINALS (4-1): Arizona's offense has yet to break the 300-yard barrier this season but still managed at least 20 points in each of the first four games. That ended against the Rams, as the Cardinals managed just 282 total yards and were limited to a field goal. The Cards could have a quarterback controversy brewing when John Skelton comes back from his ankle injury. The defense has been strong, forcing 11 turnovers.

EXTRA POINTS

1. The Cardinals have won eight straight at home, the second-longest streak in franchise history. They won nine straight in 1925.

2. Bills RB Fred Jackson needs 133 rushing yards to join Thurman Thomas (11,938), O.J. Simpson (10,183) and Joe Cribbs (4,445) as the only Bills players to reach 4,000. Jackson also needs two receptions to pass Cribbs (180) for second among Buffalo running backs behind Thomas (456).

3. Arizona WR Larry Fitzgerald needs 48 receiving yards to become the second-youngest player in NFL history with 10,000 career receiving yards. He has a reception in 122 consecutive games, the longest streak in franchise history.

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Stadium

University of Phoenix Stadium
Glendale, Arizona, USA.
Capacity: 63,400

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Last Injuries

Arizona Cardinals

  • Chris Banjo

    Hamstring
    Ques Sun | questionable

    Banjo left the previous game due to a hamstring injury, and it is uncertain if he will take the field Sunday versus the Panthers.

  • Budda Baker

    Thumb
    Doub Sun | doubtful

    Baker is not expected to be in the lineup Week 4 versus the Lions due to surgery to fix a UCL tear in his thumb.

  • Mason Cole

    Hamstring
    Ques Sun | questionable

    Cole has missed the past two games due to a hamstring injury, and it is unclear if he will return Sunday against the Panthers.

  • DeAndre Hopkins

    Ankle
    Ques Sun | questionable

    Hopkins is managing an ankle injury, and it has yet to be established if he will face the Panthers on Sunday.

  • Christian Kirk

    Groin
    Ques Sun | questionable

    Kirk sat out the last game with a groin injury, and it is unknown if he will be active against the Panthers on Sunday.

  • Byron Murphy Jr.

    Shoulder
    Prob Sun | probable

    Murphy Jr. is nursing a shoulder injury, but he is expected to line up versus the Lions on Sunday.

  • Jordan Phillips

    Ankle
    Ques Sun | questionable

    Phillips is dealing with an ankle injury, and it is uncertain if he will be available against the Lions on Sunday.

  • Dre Kirkpatrick

    Neck
    Ques Sun | questionable

    Kirkpatrick is dealing with a neck issue, leaving his status for Sunday's clash with the Lions hazy.

Buffalo Bills

  • Dion Dawkins

    Shoulder
    Ques Sun | questionable

    Dawkins was lifted from the last game with a shoulder injury, and it is unknown if he will line up against the Raiders on Sunday.

  • Micah Hyde

    Ankle
    Ques Sun | questionable

    Hyde departed the last game due to an ankle injury, and it is uncertain if he will face the Raiders on Sunday.

  • Quinton Jefferson

    Foot
    Ques Sun | questionable

    Jefferson is bothered by a foot injury, leaving his status for Sunday's clash with the Raiders unclear.

  • Zack Moss

    Toe
    Prob Sun | probable

    Moss sat out the last game with a toe injury, but it is likely that he will suit up against the Raiders on Sunday.

  • Dawson Knox

    Concussion
    Prob Sun | probable

    Knox missed the last game with a concussion and is going through the league's protocol. It is likely that he will be cleared in time for Sunday's matchup versus the Raiders.

  • Mario Addison

    Lower Body
    Ques Sun | questionable

    Addison exited the last game with a lower-body injury, and it is unclear if he will play against the Raiders on Sunday.

  • John Brown

    Calf
    Ques Sun | questionable

    Brown was forced from the previous game with a calf injury, and his availability for Sunday's contest against the Raiders is in question.

  • Cole Beasley

    Hip
    Prob Sun | probable

    Beasley is dealing with injuries to his hip and thumb, but it is expected that he will partake in Sunday's battle with the Rams.