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Arizona Wildcats vs Oklahoma State Cowboys Picks and Predictions October 4th 2025
The Oklahoma State Cowboys travel to Tucson to face the Arizona Wildcats Saturday in a Big 12 / Pac-12 crossover. Oklahoma State comes into the game amid chaos: after a 1–3 start, head coach Mike Gundy was dismissed, and defensive coordinator Todd Grantham was also shown the door. OC Doug Meacham steps in as interim head coach, while Clint Bowen will serve as interim defensive coordinator. The Cowboys’ defense has struggled mightily this season, ranking last in the Big 12 in points allowed (35.0) and yards (473). They’ve given up over 600 yards in back-to-back games (631 to Oregon, 612 to Baylor). Arizona (3–1, 0–1) enters fresh off its first loss, a 39–14 road defeat at Iowa State. QB Noah
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Texas A&m Aggies vs Mississippi State Bulldogs Picks and Predictions October 4th 2025
Two SEC teams with different momentum trends square off in College Station. Undefeated No. 6 Texas A&M is riding its best start since 2016, while Mississippi State looks to bounce back from its first loss of the season. Both teams bring strengths — and flaws — that will determine who controls this primetime showdown at Kyle Field. Week 6 of the 2025 college football season features Mississippi State traveling to face No. 6 Texas A&M on Saturday, October 4 at 7:30 PM ET, live on SECN. The Aggies opened as −13.5 favorites, but the line has pushed to −14.0 with steady support from bettors. The total has remained stable around 55.5, reflecting expectations of a moderately high-scoring SEC battle. Current
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Cincinnati Bearcats vs Iowa State Cyclones Picks and Predictions October 4th 2025
Two Big 12 programs on different paths collide in Cincinnati. The Bearcats are looking to validate their title-game aspirations under Scott Satterfield, while Matt Campbell’s unbeaten Cyclones enter as proven contenders with a top-15 ranking. This early October clash could shape the Big 12 race. Week 6 of the 2025 college football season features a key Big 12 clash as Cincinnati hosts No. 14 Iowa State at Nippert Stadium on Saturday, October 4 at 12:00 PM ET on ESPN2. The market opened with Iowa State as a slight favorite, but early money on the Bearcats shifted the line to Cincinnati −1.5. The total opened at 53.5 and moved up to 54.5, signaling expectations of another high-scoring Big 12 contest. Current
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Florida State Seminoles vs Miami Hurricanes Picks and Predictions October 4th 2025
The Florida State Seminoles and Miami Hurricanes renew their storied rivalry Saturday night at Doak Campbell Stadium in Tallahassee. Miami (4-0) is ranked No. 3 and finally leaves home after starting the year with four straight games at Hard Rock Stadium. Florida State (3-1) enters ranked No. 18, though they’re still stinging from last week’s 46-38 double-overtime road loss to Virginia. This is the first time the Seminoles and Hurricanes both enter ranked since 2016. While FSU boasts the nation’s top-scoring offense at 53 points per game, Miami counters with the ACC’s stingiest defense, allowing only 11.5 points per game. With playoff implications looming, this rivalry game carries more weight than ever. Opening odds: Miami -4.5, total 54.5. Florida State
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Maryland Terrapins vs Washington Huskies Picks and Predictions October 4th 2025
The Maryland Terrapins welcome the Washington Huskies Saturday in College Park in a Big Ten/ACC crossover test. Maryland is off to a spotless 4-0 start and has yet to trail this season. But coach Mike Locksley refuses to indulge hype. “Don’t take the cheese,” he said, warning his players not to let success breed complacency. The Terrapins’ defense has backed up that attitude — yielding just 10.8 points per game, and leading the FBS in sacks (16) and interceptions (8). Washington, meanwhile, is 3-1 but struggled last week in a 24-6 loss to No. 1 Ohio State. QB Demond Williams Jr. was efficient (18/22, 226 yards), but took six sacks and the Huskies were marred by penalties, including two called

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Notre Dame Fighting Irish vs Boise State Broncos Picks and Predictions October 4th 2025

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No. 21 Notre Dame vs Boise State Week 6 Preview Week 6 of the 2025 college football season features a high-octane matchup … more

College football preview: California Golden Bears vs Duke Blue Devils on October 4, 2025. Expert picks, betting odds, and predictions for this NCAAF matchup.

California Golden Bears vs Duke Blue Devils Picks and Predictions October 4th 2025

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Duke Blue Devils vs California Golden Bears Week 6 Betting Preview The Duke Blue Devils head west to face the California Golden … more

Northwestern Wildcats quarterback in action against UL Monroe Warhawks defender during NCAA football matchup, expert picks and betting predictions for October 4, 2025.

Northwestern Wildcats vs Ul Monroe Warhawks Picks and Predictions October 4th 2025

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Northwestern Wildcats vs ULM Warhawks Betting Preview The Northwestern Wildcats host the ULM Warhawks Saturday in Evanston, Ill., in their first ever … more

Virginia Tech Hokies quarterback prepares to throw while Wake Forest Demon Deacons defense closes in during NCAAF matchup, picks and predictions for October 4, 2025.

Virginia Tech Hokies vs Wake Forest Demon Deacons Picks and Predictions October 4th 2025

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Virginia Tech Hokies vs Wake Forest Demon Deacons Betting Preview The Virginia Tech Hokies welcome the Wake Forest Demon Deacons Saturday in … more

College football betting preview for the Baylor Bears vs Kansas State Wildcats matchup on October 4, 2025, with expert picks and game predictions.

Baylor Bears vs Kansas State Wildcats Picks and Predictions October 4th 2025

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Baylor Bears vs Kansas State Wildcats Betting Preview The Baylor Bears host the Kansas State Wildcats Saturday in Waco in a pivotal … more