San Francisco 49ers vs. Los Angeles Rams Preview and Predictions 10-13-2019

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The San Francisco 49ers are trying to supplant the Los Angeles Rams atop the NFC West and they have a great chance to take another step in that process on Sunday when they put their unbeaten record on the line in Los Angeles. The 49ers are one of two undefeated teams in the NFL following an impressive 31-3 rout of Cleveland on Monday night, and they own an early advantage in the division over Seattle and the Rams.

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Matt Breida (114 rushing yards) and Tevin Coleman (97) led the way against the Browns and are the catalysts of the league's top-rated rushing attack, which is averaging 200 yards per game. Los Angeles, which won the NFC West the last two seasons, has given up 85 points during a two-game slide and knows the competition level in the division has gone up. "The NFC West? Pretty good, huh?" quarterback Jared Goff told reporters. "We've got some good teams here. We've got to win some games and compete with these guys and expect to." The Rams won both meetings last year while averaging 43.5 points, cutting San Francisco's all-time advantage in the regular season series to 68-67-3.

TV: 4:05 p.m. ET, FOX. LINE: Rams -3. O/U: 50.5

ABOUT THE 49ERS (4-0): San Francisco's running game has taken a big hit on the injury front, as both fullback Kyle Juszczyk and right tackle Mike McGlinchey are out for about a month with knee injuries, joining left tackle Joe Staley (leg) on the sidelines. "When you lose real good players, both of your tackles and your fullback, you've always got to make adjustments," coach Kyle Shanahan told reporters. "But, you're not going to reinvent the wheel either. You've got to go out and play football and just try your hardest to put them in a position that gives them the best chance to be successful." Quarterback Jimmy Garoppolo threw for 181 yards and two touchdowns against the Browns while avoiding an interception for the first time this year.

ABOUT THE RAMS (3-2): Goff is third in the NFL in passing yards (1,649) but has tossed six interceptions over his last three games and seven on the season -- tied for the second-highest total in the league. Running back Todd Gurley, who has four rushing TDs during the two-game losing streak, is questionable for this one due to a thigh contusion. Cooper Kupp leads the receiving corps with 41 catches for 505 yards -- both of which rank in the top four in the NFL in their respective categories entering Week 6.


1. San Francisco is fourth in the league in scoring defense (14.3), while Los Angeles ranks 26th (26.8).

2. Goff has thrown for nine TDs with no interceptions in his last three games against the Niners -- all wins.

3. Rams LB Clay Matthews, who is tied for fourth in the NFL with six sacks, will miss up to six weeks with a broken jaw suffered in last week's 30-29 loss at Seattle.

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SoFi Stadium
Inglewood, California, USA.
Capacity: 70,240

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Last Injuries

Los Angeles Rams

  • Josh Reynolds

    Ques Sun | questionable

    Reynolds is dealing with an unknown illness, and it remains to be seen if he will face the Giants on Sunday.

  • Cam Akers

    Ques Sun | questionable

    Akers sat out the last game with separated rib cartilage, and it is unknown if he will suit up against the Giants on Sunday.

  • Jordan Fuller

    Ques Sun | questionable

    Fuller exited the last game with a shoulder injury, and his status for Sunday's contest against the Giants is clouded.

  • Joe Noteboom

    Out indefinitely | I-R

    Noteboom has been added to the injured reserve list with Grade 2 calf strain, and there is no indication when he will be activated.

  • Darious Williams

    Prob Sun | probable

    Williams has ankle tendinitis but is likely to take the field Sunday versus the Bills.

  • Andrew Whitworth

    Prob Sun | probable

    Whitworth exited the last game due to a calf injury, but it is likely that he will play Sunday against the Bills.

  • Malcolm Brown

    Prob Sun | probable

    Brown is recovering from surgery to repair a fractured pinky finger, but he is expected to be available Sunday versus the Bills.

  • Gerald Everett

    Prob Sun | probable

    Everett is managing a back injury but is expected to take the field against the Bills on Sunday.

San Francisco 49ers

  • Ahkello Witherspoon

    Ques Sun | questionable

    Witherspoon missed the last game with a hamstring injury, and it is up in the air if he will be active Sunday versus the Eagles.

  • Deebo Samuel

    Out indefinitely | I-R

    Samuel has ended up on the injured reserve list recovering from surgery to repair a Jones fracture in his foot. Although he is targeting a return against the Dolphins in Week 5, it is unknown when the team will activate him.

  • Emmanuel Moseley

    Ques Sun | questionable

    Moseley departed the previous game due to a concussion, and it has yet to be established if he will be cleared in time for Sunday's contest versus the Eagles.

  • Jerick McKinnon

    Ques Sun | questionable

    McKinnon has injured ribs, and there is no indication if it will keep him out of the lineup Sunday versus the Eagles.

  • Mark Nzeocha

    Out indefinitely | I-R

    Nzeocha has been shuttled to the injured reserve list due to a quad injury, and team officials have yet to provide an exact return date.

  • Raheem Mostert

    Doub Sun | doubtful

    Mostert sat out the previous game with a mild sprain of the MCL in his knee, and it is unlikely that he will play against the Eagles on Sunday.

  • Jordan Reed

    Out indefinitely | I-R

    Reed has been added to the injured reserve list due to a sprained MCL in his left knee. It is uncertain when the team will activate him.

  • Dre Greenlaw

    Ques Sun | questionable

    Greenlaw was absent from the lineup during the last game due to a thigh contusion, and it is undetermined if he will partake in Sunday's tilt versus the Eagles.