Clemson Tigers vs Syracuse Orange Picks and Predictions September 20th 2025

Clemson Tigers vs Syracuse Orange September 20th 2025

The Syracuse Orange will travel to face the Clemson Tigers in Week 4 of the 2025 regular season. The game will take place at Memorial Stadium in Clemson, South Carolina. Kickoff is set for Saturday, September 20, 2025, at 12:00 PM, and fans can catch the action on ESPN.

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Syracuse comes into this game with a 2-1 record, having played all their games at home so far. Clemson, on the other hand, holds a 1-2 record, with one win and one loss at home. Both teams are part of the Atlantic Coast Conference, adding extra significance to this matchup. Historically, Clemson has had the upper hand in recent meetings, winning the last four games against Syracuse.

Syracuse vs Clemson CFB Key Information

• Sport: College Football
• Teams: Syracuse Orange vs. Clemson Tigers
• Venue: Memorial Stadium, Clemson, SC
• Date: Saturday, September 20, 2025
• Betting Odds: Syracuse Moneyline +559, Clemson Moneyline -815, Syracuse Spread +17.5 (-112), Clemson Spread -17.5 (-109), Total Over 55.5 (-107), Total Under 55.5 (-113)

Clemson looks to rebound at home against Syracuse

The Clemson Tigers enter Saturday’s ACC clash searching for answers after dropping out of the AP Top 25. At 1-2, Dabo Swinney’s group has yet to put together a complete performance and now faces the nation’s top-ranked passing attack in the Syracuse Orange. Syracuse (2-1) is coming off a 66-24 rout of Colgate and brings confidence into Death Valley as a two-touchdown underdog. Bettors tracking college football picks will find plenty of intrigue in this matchup of strengths and vulnerabilities.

Betting Odds and Trends

The Syracuse Orange Can Win If…

The Syracuse Orange thrive behind quarterback Steve Angeli, who leads the nation in passing yards (1,108). Against Colgate, Angeli threw for 382 yards and five touchdowns, helping Syracuse pile up 447 passing yards. His connection with receivers like Darrell Gill Jr. (269 yards) and Justus Ross-Simmons gives the Orange the ability to strike quickly.

Syracuse ranks third nationally in passing offense and third in interceptions defensively, a combination that allows them to create scoring chances on both sides of the ball. Their secondary has been opportunistic, which could pressure Clemson’s Cade Klubnik into mistakes.

Depth remains a strength despite injuries. Gill Jr. and Ross-Simmons provide reliable targets, while Demon June adds balance with over 200 rushing yards. If Syracuse protects Angeli in the pocket and wins the turnover battle, they can keep this game close.

The Clemson Tigers Can Win If…

The Clemson Tigers must lean on their defense to slow down Syracuse’s passing attack. They rank ninth in sacks and fourth in both interceptions and fumbles recovered. Generating pressure up front and capitalizing on mistakes could shift momentum back in their favor.

Quarterback Cade Klubnik has shown flashes, throwing for 621 yards and six touchdowns this season, but inconsistency has plagued the Tigers. Against Georgia Tech, he finished 15-of-26 for 207 yards with a touchdown, an interception, and a costly fumble. Klubnik must be more efficient and avoid turnovers to prevent Syracuse from stealing possessions.

Running back Adam Randall (208 yards, 3 TDs) and wide receiver Bryant Wesco Jr. (310 yards, 3 TDs) provide Clemson with playmaking options. If the offensive line controls the trenches and Klubnik connects with Wesco on explosive plays, the Tigers have the tools to cover the spread.

The Lean

The line favors Clemson -17.5, but recent struggles suggest that might be too steep. Syracuse has been excellent against the spread as an underdog, and their passing attack can expose Clemson’s secondary. Our projection leans toward Clemson winning 30-20, making Syracuse +17.5 the stronger play.

The total sits at 55.5, and while both teams are capable of scoring, defenses may limit fireworks. With Syracuse’s air attack running into Clemson’s pass rush, drives could stall. The projection of 50 total points leans toward the under.

Game Preview Recap

Clemson is desperate to reset after falling out of the Top 25 with losses to LSU and Georgia Tech. Swinney has emphasized finding “four quarters of complementary football,” something the Tigers haven’t produced this season. Klubnik remains talented but turnover-prone, and the defense has given up big plays at critical moments.

Syracuse enters with confidence after dominating Colgate and overcoming early-season adversity. Angeli has been the nation’s most prolific passer through three weeks, spreading the ball effectively to a deep receiving corps. Coach Fran Brown dismissed oddsmakers’ doubts, saying, “I don’t care what Vegas says…we’ll give ourselves a chance to win.”

Clemson owns the all-time series 10-2 and has won six straight against the Orange. Syracuse is 0-5 all-time in Clemson, making Saturday another chance to break a long-standing road drought.

With Clemson reeling and Syracuse rolling, this game carries upset potential if the Orange’s passing attack finds rhythm early.

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