Colorado Buffaloes vs Byu Cougars Picks and Predictions September 27th 2025

Colorado Buffaloes vs BYU Cougars September 27th 2025

The BYU Cougars will take on the Colorado Buffaloes in Week 5 of the 2025 regular season. The game is set for Saturday, September 27, at Folsom Field in Boulder, Colorado. Kickoff is scheduled for 10:15 PM and will be broadcast on ESPN.

BYU enters the game with a perfect 3-0 record. They are ranked #25 in the AP Poll and #24 in the Coaches Poll. Meanwhile, the Colorado Buffaloes hold a 2-2 record this season. Both teams are part of the Big 12 Conference. Last season, BYU defeated Colorado 36-14 in the Valero Alamo Bowl.

BYU vs Colorado CFB Key Information

• Sport: College Football
• Teams: BYU Cougars vs. Colorado Buffaloes
• Venue: Folsom Field in Boulder, CO
• Date: Saturday, September 27, 2025
• Betting Odds: BYU Moneyline -242, Colorado Moneyline +198, BYU Spread -6.5 (-112), Colorado Spread +6.5 (-108), Total Over/Under 47.0 (-110)

BYU vs Colorado Week 5 Betting Preview

The BYU Cougars hit the road Saturday to face the Colorado Buffaloes in Boulder. This is BYU’s first Big 12 matchup of the year, and it comes against a Colorado team that just snapped a losing streak with a 37–20 win over Wyoming.

The Cougars dominated East Carolina last week 34–13 behind QB Bear Bachmeier’s 246 yards passing and a defense that forced three turnovers. That same unit ranks first nationally in points allowed.

Line Movement and Odds

Oddsmakers opened BYU as a 6.5-point favorite with a total of 48.5. The college football odds board shows steady support for BYU, though sharp bettors have eyed Colorado at home.

Matchup Breakdown

BYU Cougars

• Bachmeier is improving weekly, completing 72 percent of passes.
• RB LJ Martin has 342 rushing yards.
• WR Chase Roberts is closing in on 2,000 career receiving yards.
• The defense has surrendered only 16 points in three games.

Colorado Buffaloes

• QB Kaidon Salter threw for 304 yards and 3 TDs vs Wyoming.
• WR Sincere Brown is the deep threat, with 203 yards and 2 TDs.
• Defense thrives on takeaways but struggles with chunk plays.

The key battle is Colorado’s big-play passing game against BYU’s disciplined coverage.

Injuries and Conditions

Neither team reports major injuries entering the weekend. Boulder weather is clear, which should help both passing attacks.

Best Bets and Prediction

Projected score: BYU 31, Colorado 20

• Best Bet: BYU –6.5
• Secondary Lean: Over 48.5

BYU’s balance on offense and elite defense make them the side to back.

Handicapping Angle

Check the latest college football picks for more plays on this matchup. Track expert records on the Handicapper Leaderboard and dive into the best handicappers section for deeper analysis. If you want betting education, the Bettors Handbook offers strategy insights to sharpen your edge.