Florida Gators vs South Florida Bulls Picks and Predictions September 6th 2025

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Southern Showdown: No. 13 Florida vs. USF Preview — Week 2 (College Football)

Both Florida and South Florida enter the upcoming Sunshine State clash undefeated, setting the stage for a rare—and high-stakes—in-state rivalry game in Gainesville.

The Florida Gators (No. 13) and the USF Bulls each enter Week 2 unbeaten—albeit with vastly different trajectories. Florida dominated Long Island University with a 55‑0 blowout, while USF stunned then-ranked Boise State 34‑7, thanks to strong play from senior QB Byrum Brown. Now, these Sunshine State neighbors meet in just the fourth showdown in series history, with Florida holding a perfect 3‑0 record.

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Florida Can Win If…

  • Their offense keeps rolling — DJ Lagway and Tramell Jones Jr. combined for five TD passes in Week 1, spreading production across 15 receivers.
  • Defense maintains dominance — Florida held LIU to just 86 total yards with a lopsided advantage in first downs (28–2).

“Whenever I feel like I’m kind of going into a dark space … I always lean on my dad,” said Eugene Wilson III, who returned from hip surgery to catch a TD.

USF Can Win If…

  • Byrum Brown stays efficient and effective — He threw for 210 yards and added 43 yards on the ground, showing versatility under pressure.
  • GTaj Nimrod and Singleton stay involved — The transfer duo combined for nearly 200 receiving yards and a TD.
  • Momentum from their Boise State upset carries over — They forced three turnovers and controlled the trenches all night.

“I give Byrum a lot of credit … he came over and said, ‘Coaches, run me a little bit.’ … Then I watched him put his shoulder down twice,” said coach Alex Golesh.


Key College Football Betting Trends

CategoryFlorida GatorsUSF Bulls
Record1–0 (dominant win)1–0 (statement win)
Recent PerformanceExplosive offenseGrounded, physical win
QB PlayBalanced and effectiveDual-threat from Brown
Series History3–0 all-time vs. USFSeeking first win
Home-field AdvantageStrong at homeFacing hostile environment

The Lean

Model Projection: Florida 38, USF 24
Pick: Florida Moneyline
Total Lean: Over 56

Florida’s offensive rhythm and historical edge make them the safer bet. But expect USF to hang around thanks to their physical play and confidence from Week 1’s upset. For more analysis and picks, head to our NCAAF Betting Advice hub.


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