Louisville Cardinals vs Boston College Eagles Picks and Predictions October 25th 2025

Boston College Eagles vs Louisville Cardinals Game Preview

The Boston College Eagles travel to face the Louisville Cardinals on Saturday, October 25, 2025, at L&N Federal Credit Union Stadium in Louisville, KY. Kickoff is set for 7:30 PM ET on ACCN.

Louisville (5-1, 2-1 ACC) enters the matchup ranked No. 19 nationally after a thrilling 24-21 upset win over No. 2 Miami. Under coach Jeff Brohm, the Cardinals have consistently knocked off top teams but have struggled in letdown spots. Boston College (1-6, 0-4 ACC) has lost six straight and looks to snap its skid in a hostile environment.

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Line Movement and Betting Odds

Boston College Moneyline: +1390
Louisville Moneyline: -3389
Boston College Spread: +25.5 (-110)
Louisville Spread: -25.5 (-110)
Total Over/Under: 55.5 (-110)

Louisville opened as a heavy favorite following its signature win over Miami, while Boston College enters as one of the ACC’s lowest-ranked teams. The total reflects expectations for an aggressive Louisville offense against a struggling defense.

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Boston College Eagles

Boston College is coming off a 38-23 loss to UConn, where the defense allowed 21 unanswered points in the second half. Quarterback Grayson James threw for 204 yards and two touchdowns but was sacked seven times as protection broke down.

Despite their struggles, the Eagles have shown offensive flashes, ranking 28th in passing yards this season. James brings mobility and a quick release that can help neutralize Louisville’s aggressive pass rush. The running game, led by Kye Robichaux, adds balance when the offensive line holds up.

Defensively, Boston College has forced turnovers but remains inconsistent, ranking near the bottom of the ACC in points allowed. To stay competitive, the Eagles will need to limit explosive plays from Chris Bell and contain Louisville’s tempo-driven offense.

Injury Report

Cameron Martinez (DB) – Questionable (Undisclosed)
Jaylen Blackwell (LB) – Questionable (Undisclosed)
Owen Stoudmire (DT) – Questionable (Undisclosed)
Amari Jackson (DB) – Questionable (Leg)
Daveon Crouch (LB) – Questionable (Undisclosed)
Palaie Faoa (LB) – Questionable (Undisclosed)
Jaedn Skeete (WR) – Questionable (Undisclosed)
Johnathan Montague Jr. (WR) – Out (Knee)
Syair Torrence (DB) – Questionable (Undisclosed)
Danny Edgehille (TE) – Questionable (Undisclosed)
Sterling Sanders (DL) – Questionable (Undisclosed)

Full injury report for Boston College Eagles

Louisville Cardinals

Louisville rides momentum after upsetting No. 2 Miami, a win powered by Miller Moss’ 248 passing yards and a defense that intercepted four passes. The Cardinals’ offense has been balanced all season, averaging 31.7 points per game while ranking top 50 nationally in both rushing and passing production.

Wide receiver Chris Bell has been sensational, posting 31 catches for 441 yards and five touchdowns over the past three games. His chemistry with Moss has made Louisville’s air attack one of the most efficient in the ACC. The defense remains elite, ranking 10th nationally in total yards allowed and tied for 12th in takeaways.

Jeff Brohm’s team has a history of emotional highs followed by letdowns, but the focus this week is clear: avoid mistakes, protect Moss, and finish strong at home.

Injury Report

• Mak Pounders (OL) – Questionable (Undisclosed)
• Naeer Jackson (OL) – Questionable (Undisclosed)
• Stanquan Clark (LB) – Out (Ankle)
• Travis Egan (QB) – Questionable (Undisclosed)
• Duke Watson (RB) – Questionable (Undisclosed)
• Shammai Gates (RB) – Questionable (Undisclosed)
• Jamarice Wilder (RB) – Questionable (Undisclosed)
• Tyler Folmar (OL) – Questionable (Undisclosed)

Full injury report for Louisville Cardinals

Key Storylines

• Louisville has upset three top-15 teams in the past two seasons but lost the following week each time.
• Boston College has dropped six straight and is 0-4 in ACC play.
• Chris Bell ranks third nationally in receiving yards per game (106.3).
• Louisville’s defense ranks top-10 in total yards allowed and top-15 in takeaways.
• The Cardinals are 19-4 straight up in their last 23 home games.

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Prediction

Louisville’s superior talent and defensive discipline should overwhelm Boston College. The Eagles’ offensive line issues make this a tough matchup against one of the ACC’s most aggressive fronts. Expect the Cardinals to start fast and maintain control throughout.

Projected Score: Louisville 42, Boston College 14
Best Bet: Louisville -25.5 (-110)
Secondary Lean: Over 55.5 (-110)

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