Memphis Tigers vs South Florida Bulls Picks and Predictions October 25th 2025

South Florida Bulls vs Memphis Tigers Game Preview

The South Florida Bulls head to Tennessee to face the Memphis Tigers on Saturday, October 25, 2025, at Simmons Bank Liberty Stadium. Kickoff is set for 12:00 PM ET on ESPN.

South Florida (6-1, 3-0 AAC) enters ranked No. 18 in the AP Poll, led by an explosive offense that continues to climb the national leaderboard. Memphis (6-1, 2-1 AAC) saw its momentum stall after a stunning loss to UAB last weekend and now looks to reset in front of a home crowd.

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Line Movement and Betting Odds

South Florida Moneyline: -210
Memphis Moneyline: +174
South Florida Spread: -5.0 (-110)
Memphis Spread: +5.0 (-110)
Total Over/Under: 63.5 (-110)

South Florida opened as a road favorite thanks to its dynamic quarterback play and depth on both sides of the ball. The total reflects the expectation of a high-scoring, up-tempo contest between two of the AAC’s top offenses.

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South Florida Bulls

South Florida continues to surge behind the leadership of quarterback Byrum Brown, who accounted for 367 total yards and four touchdowns in last week’s 48-13 rout of Florida Atlantic. The Bulls rank among the top five nationally in scoring, averaging over 40 points per game, and remain one of the most efficient rushing teams in the country.

Brown has been unstoppable over the past month, tallying 18 touchdowns across his last four games. His combination of passing precision and mobility has fueled a unit that thrives on tempo — South Florida ranks among the national leaders in plays per game and minimal time of possession per drive.

Defensively, the Bulls have taken major strides. They rank top 15 in both sacks and interceptions, creating timely turnovers that have allowed the offense to maintain control of games. With a 6-1 start and a chance to solidify their AAC dominance, confidence is sky-high for Alex Golesh’s squad.

Injury Report

• Weston Wolff (TE) – Questionable (Undisclosed)
• Jaden Alexis (WR) – Questionable (Undisclosed)
• Boogsie Silvera (DB) – Out (Undisclosed)
• Sam Franklin (RB) – Questionable (Undisclosed)
• Cartevious Norton (RB) – Out (Undisclosed)
• Chas Nimrod (WR) – Questionable (Undisclosed)
• Izaiah Guy (CB) – Questionable (Undisclosed)
• Greg Otten (LB) – Out (Undisclosed)
• Braden Carter (OL) – Questionable (Undisclosed)
• Kory Pettigrew (WR) – Questionable (Undisclosed)
• Michael Williams II (DE) – Questionable (Undisclosed)
• Richard Scott III (DE) – Questionable (Undisclosed)

Full injury report for South Florida Bulls

Memphis Tigers

Memphis saw its unbeaten run snapped in a shocking 31-24 road loss to UAB, a result that dropped the Tigers from the national rankings. The setback overshadowed what has otherwise been a strong campaign, highlighted by a top-15 rushing attack and efficient scoring.

The biggest question for coach Ryan Silverfield this week is at quarterback. Starter Brendon Lewis exited last week’s loss with a lower-body injury and remains day-to-day. If he cannot go, freshman A.J. Hill or Arrington Maiden could see action under center.

Lewis has been the catalyst for Memphis’ offense, throwing for 1,337 yards and eight touchdowns while rushing for another 440 yards and seven scores. Running back Sutton Smith provides balance with 480 rushing yards and six touchdowns, while receiver Cortez Braham Jr. remains a consistent downfield threat.

Memphis is 10-0 straight up in its last ten home games and will rely on crowd energy to help reset its AAC title hopes.

Injury Report

• Cameron Miller (DB) – Questionable (Undisclosed)
• Brendon Lewis (QB) – Questionable (Leg)
• Joey Hunter (DB) – Questionable (Undisclosed)
• Kourtlan Marsh (DB) – Out (Undisclosed)
• Jerry Cross (TE) – Questionable (Undisclosed)
• Cade Law (LB) – Out (Undisclosed)
• Oliver Castaneda (K) – Questionable (Undisclosed)

Full injury report for Memphis Tigers

Key Storylines

• South Florida quarterback Byrum Brown has 18 total touchdowns in his last four games.
• Memphis has won eight of its last ten meetings against South Florida, including four straight.
• Both teams enter at 6-1, making this a key AAC title-race matchup.
• Memphis ranks top 15 nationally in rushing offense, while South Florida ranks top five in scoring.
• South Florida has gone 10-1 straight up as a favorite over its last 11 games.

Prediction

South Florida’s offensive balance and defensive improvement make them a tough matchup for any AAC opponent. Memphis has been dominant at home, but the uncertainty at quarterback and recent struggles against mobile QBs tilt the edge to the Bulls. Expect a back-and-forth first half before South Florida’s tempo takes over late.

Projected Score: South Florida 34, Memphis 28
Best Bet: Memphis +5.0 (-110)
Secondary Lean: Over 63.5 (-110)

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