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Louisville Cardinals vs Miami Hurricanes Game Preview
High-powered offenses meet elite defenses as the Louisville Cardinals visit the No. 2 Miami Hurricanes in a primetime ACC showdown. Both teams have combined for over 320 points in their last four meetings — but this time, defense might decide the outcome.
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Line Movement and Odds
The Hurricanes opened as −12.5 favorites, and early money quickly pushed the line to −13.5, signaling strong market confidence in Miami’s dominance at home. Louisville enters as a dangerous underdog behind quarterback Miller Moss, who continues to post strong numbers despite a depleted backfield.
- Moneyline: Louisville +430 / Miami −594
- Spread: Louisville +13.5 (−106) / Miami −13.5 (−113)
- Total: Over/Under 52.5 (−110)
Check real-time odds and updates on the college football scores and odds board.
Matchup Breakdown
Miami (5-0, 1-0 ACC) returns home fresh off a 28-22 win over Florida State, where quarterback Carson Beck threw for 241 yards and two touchdowns. The Hurricanes’ balanced offense ranks among the ACC’s best, while their defense allows just 276.4 total yards per game — 16th nationally.
Louisville (4-1, 1-1 ACC) fell 30-27 in overtime to Virginia before a bye week, struggling with turnovers but continuing to find success through the air. Quarterback Miller Moss has thrown for 1,358 yards this season, keeping the Cardinals’ offense moving even with injuries in the backfield.
The Hurricanes’ front seven will test a Cardinals offensive line that has allowed too much pressure in recent weeks. Expect Miami’s pass rush, anchored by Rueben Bain Jr., to be a major factor.
Injuries and Conditions
Louisville Cardinals
- DB Rodney Johnson — Questionable (undisclosed)
- LB Stanquan Clark — Out (ankle)
- QB Travis Egan — Questionable (undisclosed)
- RB Shammai Gates — Questionable (undisclosed)
- RB Jamarice Wilder — Questionable (undisclosed)
- OL Tyler Folmar — Questionable (undisclosed)
Miami Hurricanes
- LB Bobby Washington Jr. — Questionable (undisclosed)
- TE Jackson Carver — Questionable (undisclosed)
- WR Chance Robinson — Questionable (undisclosed)
- DL Daylen Russell — Questionable (undisclosed)
- Multiple linemen (OL Yerovi Valdes Alfonso, Ralph Scroggins) listed as questionable.
Miami’s depth advantage remains significant — especially at running back, where Mark Fletcher Jr. has filled in capably for injured reserves.
Betting Trends
- Miami is 10-0 straight up at home since 2024.
- Louisville is 5-1 SU on the road over the past two seasons.
- Miami is 3-0 ATS as a favorite in 2025.
- Louisville has hit the Over in 3 straight road games.
- Miami is 16-2 SU in all games since 2023.
Best Bets and Prediction
The Hurricanes’ home dominance and balanced attack make them tough to fade, but Louisville’s ability to strike through the air should keep it competitive early. Expect Miami’s defense to wear the Cardinals down by the second half.
- Spread Lean: Miami −13.5 (−113)
- Total Lean: Over 52.5 (−110)
- Projected Score: Miami 31, Louisville 17
For deeper betting breakdowns and college football systems, visit the NCAAF expert betting guide.
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Handicappers and Service Plays
Miami has covered the spread in every game as a home favorite this season, while Louisville has gone over in every road matchup. Consensus handicappers are leaning heavily toward Miami −13.5 and the Over, with sharp money aligning on the favorite.
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