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Michigan vs Purdue Week 10 Betting Preview
No. 21 Michigan looks to stay on track for a Big Ten title push when it hosts Purdue on Saturday night in Ann Arbor. The Wolverines (6-2, 4-1 Big Ten) are unbeaten at home and enter off a 31-20 win at Michigan State, while the Boilermakers (2-6, 0-5) have dropped six straight under first-year coach Barry Odom.
Michigan has leaned on its defense and running game, ranking fourth in the Big Ten in rushing at 220.1 yards per game and allowing only 95.5 yards on the ground. Freshman quarterback Bryce Underwood continues to gain confidence behind a dominant offensive line. Junior running back Justice Haynes, who transferred from Alabama, leads the conference with 857 yards and has been the engine of the Wolverines’ attack.
For Purdue, finding consistency remains a struggle. The Boilermakers’ minus-11 turnover margin is the worst in the conference, but their passing game has shown flashes behind Ryan Browne, who’s thrown for 1,689 yards and eight touchdowns.
Fans can find full matchup previews on the NCAA football previews page
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Line Movement and Odds
According to the latest numbers from the college football odds page Michigan opened as a -21 favorite with a total of 49.5 points. The Wolverines’ moneyline sits around -1798, while Purdue is a longshot at +962.
Early betting action has been one-sided, with over 75% of public money backing Michigan to cover. Sharper bettors, however, have shown slight resistance near the key number of 21. The total has held steady after opening at 49.5, suggesting balanced action between Over and Under bettors.
Matchup Breakdown
Michigan Outlook:
The Wolverines’ identity remains built on physicality. They rank top 15 nationally in rushing offense and top 20 in scoring defense (17.4 points per game allowed). Haynes and sophomore Jordan Marshall combine for 1,401 rushing yards and 11 touchdowns. Defensively, Michigan ranks ninth in sacks (22) and 12th in interceptions (11), giving them a clear edge in both trenches.
Purdue Outlook:
The Boilermakers rank 44th in passing offense and remain capable of explosive plays when Browne has time. Running back Devin Mockobee’s 218-yard performance against Rutgers last week highlighted Purdue’s potential balance, but turnovers continue to be costly. Purdue’s defense allows over 160 rushing yards per game, which could be an issue against Michigan’s power run game.
If Purdue protects the ball, it can compete for stretches, but sustained drives against Michigan’s front seven will be a challenge.
Injuries and Conditions
Michigan Wolverines Injury Report:
- C.J. Charleston (WR) – Out
- Davis Warren (QB) – Questionable (knee)
- Rod Moore (DB) – Questionable
- Evan Link (OL) – Questionable
- Micah Kaʻapana (RB) – Questionable
- Devon Baxter (DE) – Out
Purdue Boilermakers Injury Report:
- Myles Slusher (DB) – Questionable
- Chauncey Magwood (WR) – Questionable
- TJ Lindsey (DL) – Out
- Marques Easley (OL) – Questionable
- Jalil Hall (WR) – Out
Best Bets and Prediction
Michigan is 29-1 straight up as a favorite in its last 30 games and 5-0 ATS following a loss. Purdue is 10-18 ATS as an underdog over its last 28.
Projected Score: Michigan 38, Purdue 14
Best Bet: Michigan -21
Secondary Lean: Over 49.5
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