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Ole Miss Rebels vs Oklahoma Sooners Game Preview
The Ole Miss Rebels head to Norman for a high-stakes Week 9 matchup against the Oklahoma Sooners on Saturday, October 25, 2025. Kickoff is set for 12:00 PM ET at Memorial Stadium, with national coverage on ABC.
This game features a clash of philosophies — Lane Kiffin’s explosive Ole Miss offense against Brent Venables’ disciplined and aggressive Oklahoma defense. Both teams enter at 6-1 and ranked inside the top 15, setting up a pivotal contest that could impact playoff positioning.
Ole Miss is coming off a 43-35 shootout loss at Georgia, while Oklahoma rebounded from its defeat to Texas with a dominant 26-7 win over South Carolina. Saturday marks the Rebels’ first trip to Norman and their third-ever meeting with the Sooners — they’ve won the previous two matchups, including last year’s 26-14 victory in Oxford.
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Line Movement and Betting Odds
Ole Miss Moneyline: +173
Oklahoma Moneyline: -208
Ole Miss Spread: +4.5 (-108)
Oklahoma Spread: -4.5 (-112)
Total Over/Under: 54.5 (-108 / -113)
Oklahoma opened as a 4.5-point favorite at home, with early bettors backing the Sooners’ defensive dominance. The total sits at 54.5, reflecting expectations for a competitive but disciplined matchup between two well-coached teams.
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Matchup Breakdown
Ole Miss continues to thrive behind quarterback Trinidad Chambliss, who has thrown for 1,549 yards, eight touchdowns, and just one interception. The Rebels rank ninth nationally in passing yards (2,129) and ninth in first downs (176). Running back Kewan Lacy has been the engine of the offense, rushing for 618 yards and 10 touchdowns.
Defensively, Ole Miss ranks among the top teams in interceptions, sitting fourth nationally. That turnover production will be vital against an Oklahoma team that thrives on momentum and field position.
Oklahoma’s success begins with its defense — Venables’ unit leads the nation in total defense (213 yards per game), sacks (29), and tackles for loss (10.7 per game). Quarterback John Mateer has provided balance on offense, throwing for 1,567 yards and managing the game efficiently. Running back Tory Blaylock has added 393 rushing yards, giving the Sooners a reliable ground threat.
Both teams feature strong play in the trenches, setting up a true coaching chess match between Kiffin’s offensive creativity and Venables’ defensive precision.
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Key Storylines
This matchup pits two elite minds against each other — Lane Kiffin’s tempo-heavy spread offense against Brent Venables’ film-savvy, blitz-driven defense. Oklahoma leads the nation in sacks and tackles for loss, while Ole Miss has allowed just seven sacks all season.
The Rebels’ offensive line protection versus the Sooners’ pass rush will determine whether Chambliss can find his playmakers downfield. Meanwhile, Oklahoma’s home-field edge and defensive depth could force Kiffin’s squad into shorter possessions than usual.
Beyond the on-field battle, Kiffin’s name has circulated in coaching rumors following Florida’s vacancy, but his players insist the focus remains squarely on Norman.
Injury Report
Ole Miss Rebels:
Safety Ladarian Clardy (undisclosed) is questionable, marking the only notable concern for a mostly healthy roster.
Oklahoma Sooners:
Wide receiver Keontez Lewis (undisclosed) and tight end Kade McIntyre (undisclosed) are questionable. Running back Jovantae Barnes (undisclosed) is also questionable, while offensive lineman Troy Everett (undisclosed) is out. Multiple offensive linemen — Jacob Sexton, Jake Taylor, and Logan Howland — are all listed as questionable, which could impact Oklahoma’s protection schemes. Defensive back Kendel Dolby (undisclosed) is questionable as well.
Prediction
Ole Miss’ offensive rhythm will challenge Oklahoma’s top-ranked defense, but the Sooners’ home advantage and defensive pressure should tilt the game in their favor. Expect a low-scoring contest relative to both teams’ season averages, as field position and third-down conversions dictate momentum.
Projected Score: Oklahoma 28, Ole Miss 21
Best Bet: Oklahoma -4.5 (-112)
Secondary Lean: Under 54.5 (-113)
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