Ole Miss Rebels vs Florida Gators Picks and Predictions November 15th 2025

Ole Miss Rebels vs Florida Gators Week 12 Betting Preview

Ole Miss enters Week 12 at 9-1 and still alive in the playoff race, even with Lane Kiffin sitting in the middle of another round of coaching rumors. You remember Florida knocking the Rebels out of contention last season, a 24-17 upset that still lingers in Oxford. The rematch arrives Saturday night at Vaught-Hemingway Stadium, and you can track updated numbers any time on the NCAA odds page

Florida makes the trip at 3-6, still winless on the road, and still trying to stabilize under interim leadership. Ole Miss sits undefeated at home and remains a heavy favorite to stay that way. Florida’s offense is back in the hands of DJ Lagway, although the turnovers have become a real concern after last week’s 38-7 loss.

Kiffin brushed off the rumor mill, but his quarterback situation has stabilized behind Trinidad Chambliss, who continues to produce at a top-tier level through the air. Ole Miss brings one of the strongest passing profiles in the SEC. Florida brings a defense that has struggled against elite efficiency.

Line Movement and Odds

The spread opened smaller earlier in the week, then climbed steadily as sharper money backed Ole Miss. The current market sits around Ole Miss −16.5, which aligns with the Rebels’ home dominance and Florida’s recent losses by wide margins.

Moneyline pricing sits near Ole Miss −700 and Florida around +500. The total of 53.5 has held steady. Public bettors are leaning toward the favorite and toward points. For line checks throughout the week, use the college football previews page

Matchup Breakdown

Ole Miss owns the statistical edge in every major offensive category. They rank near the top nationally in passing yards, explosive plays, and first-down creation. Chambliss has thrown for more than 2,300 yards with only two interceptions, and the run game remains efficient enough to keep Florida’s linebackers stressed.

Florida’s path involves turnovers. The Gators rank highly in forced fumbles and interceptions, and they’ll need that to stay competitive. Lagway has struggled against pressure, and Ole Miss ranks top-15 nationally in sack rate. If the Rebels win the trenches, they control the entire game flow.

For those looking to compare models and expert insights, the free NCAA picks section offers supporting data points across matchups.

Injuries and Conditions

Ole Miss

• Antonio Kite (CB) – Questionable.

Full details: Ole Miss injury report

Florida

• Caleb Banks (DL) – Questionable.
• Taylor Sierto (WR) – Questionable.
• Micheal Caraway Jr. (DB) – Questionable.
• Javion Toombs (DB) – Questionable.
• Grayson Howard (LB) – Questionable.
• Aaron Gates (DB) – Questionable.
• Dijon Johnson (DB) – Questionable.
• Treyaun Webb (RB) – Questionable.
• Ja’Kobi Jackson (RB) – Questionable.
• LJ McCray (DE) – Questionable.
• Ty Jackson (LB) – Questionable.

Full details: Florida injury report

Best Bets and Prediction

Ole Miss is 20-1 straight up at home since 2023. Their passing attack should carve out consistent chunk gains, and Florida’s struggles in road environments make the Gators a tough team to back as a double-digit dog.

Projected Score: Ole Miss 42, Florida 17
Best Bet: Ole Miss −16.5
Secondary Lean: Over 53.5

For bankroll structure and situational betting edges, the Bettors Handbook breaks down angles that fit this matchup.

ScoresAndStats Handicappers and Picks

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