Ole Miss Rebels vs Lsu Tigers Picks and Predictions September 27th 2025

Ole Miss Rebels vs LSU Tigers September 27th 2025

The LSU Tigers and Ole Miss Rebels meet in Week 5 of the 2025 college football season. The game is set for Saturday, September 27, at Vaught-Hemingway Stadium in Oxford, Mississippi. Both teams enter the game with a 4-0 record, making this a key SEC matchup.

LSU is ranked #4 in both the AP and Coaches Polls. They have a strong start this season, with a 1-0 record on the road. Ole Miss holds the #13 AP rank and #11 in the Coaches Poll. They are also undefeated at home this season, with a 3-0 record. The game will air on ABC at 3:30 PM ET.

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LSU vs Ole Miss CFB Key Information

• Sport: College Football
• Teams: LSU Tigers vs. Ole Miss Rebels
• Venue: Vaught-Hemingway Stadium, Oxford, MS
• Date: Saturday, September 27, 2025
• Betting Odds: LSU Moneyline -101, Ole Miss Moneyline -119, LSU Spread +1.5 (-110), Ole Miss Spread -1.5 (-110), Total Over/Under 54.5

LSU Can Win If…

The LSU Tigers are coming off a strong performance against the Southeastern Louisiana Lions, winning 56-10. In that game, LSU’s passing attack was on point, with 395 passing yards and no turnovers. Garrett Nussmeier, their quarterback, has been a key player, throwing for 960 yards and six touchdowns over four games.

LSU’s offense ranks 23rd in passing yards this season, showing their ability to move the ball through the air. They also have a solid defense, ranked 15th for points against. With 11 sacks and six interceptions, their defense can pressure opponents and create turnovers.

LSU’s ability to win games comes from a balanced team effort. Their defense ranks 7th in sacks, showing their ability to disrupt the opposing quarterback. Despite injuries, key players like Nussmeier and wide receiver Aaron Anderson, with 293 receiving yards, can make big plays to secure a win.

Ole Miss Can Win If…

In their most recent game, the Ole Miss Rebels had a strong performance, defeating Tulane 45-10 at Vaught-Hemingway Stadium. The Rebels’ offense was on point, with 307 passing yards and 241 rushing yards. Trinidad Chambliss led the way with solid quarterback play, while Kewan Lacy added strength to the ground game.

The Rebels have been strong offensively this season, ranking 10th in points scored with 179 and 9th in passing yards with 1,299. Their rushing game is also effective, ranking 20th with 882 yards. Their ability to move the chains is evident, as they rank 11th in first downs with 102, showing their capability to control the game.

Ole Miss has a solid defense, ranking 14th in sacks and 3rd in interceptions, which can disrupt opposing offenses. Players like Kewan Lacy and Harrison Wallace III have been key contributors, providing scoring options and yardage. With a balanced attack and strong defense, the Rebels are well-equipped to secure another victory at home.

The Lean

For the spread pick, Ole Miss is favored by 1.5 points at home. Our model projects Ole Miss to win 31-28. Given Ole Miss’s strong home record and recent performance, taking Ole Miss -1.5 is the recommendation.

For the over/under pick, the total is set at 54.5 points. Our model predicts a total score of 59 points. Both teams have shown strong offensive capabilities, so the recommendation is to take the over 54.5.

LSU vs Ole Miss Week 5 Betting Preview

The LSU Tigers and the Ole Miss Rebels meet Saturday in Oxford for a Magnolia Bowl clash with major SEC implications. LSU is 4-0 with a defense allowing only 9.3 points per game, while Ole Miss is 4-0 behind a tempo offense averaging 543 yards per contest.

This rivalry has delivered shootouts and nail-biters: LSU edged Ole Miss 29-26 last season, while the Rebels won 55-49 in 2023.

Line Movement and Odds

Oddsmakers opened Ole Miss as a small home favorite. Current numbers on the college football odds board show Ole Miss –1.5 with a total of 55.5. Moneyline pricing has Ole Miss –120 and LSU even money (+100).

Public action leans to the Rebels, but sharp bettors have shown interest in LSU as an underdog.

Matchup Breakdown

LSU Tigers
Coach Brian Kelly has reshaped this defense. LSU ranks top 20 in both scoring and total defense, holding opponents to under 250 yards per game. QB Garrett Nussmeier finally got rhythm in last week’s 56-10 win, and RB Caden Durham gives the Tigers a ground option.

Ole Miss Rebels
Lane Kiffin’s offense is balanced: ~324 passing yards and ~218 rushing yards per game. QB Austin Simmons (ankle) has been limited, so Trinidad Chambliss has stepped in with back-to-back strong outings. The Rebels’ defense, however, allows nearly 190 rushing yards per game — a potential weakness LSU can exploit.

Key battle
LSU’s defensive front against Ole Miss’s high-speed tempo. If LSU forces early three-and-outs, the Tigers can slow the pace. If Chambliss finds rhythm, the Rebels’ offense could dictate the game.

Injuries and Conditions

Vaught-Hemingway Stadium in Oxford will be loud, but no weather impact is expected.

Best Bets and Prediction

Projected score: Ole Miss 28, LSU 24 (52 total)

• Best bet: Ole Miss –1.5
• Secondary lean: Under 55.5

LSU’s defense gives them a chance, but Ole Miss’s explosive tempo and home field edge tilt the matchup slightly toward the Rebels.

Handicapping Angle

For deeper breakdowns, the Handicapper Leaderboard shows which experts are hottest. Bettors can compare angles through Service Plays and find cross-sport opportunities in NFL picks. If you’re sharpening bankroll management, the Bettors Handbook is a must-read.