Ole Miss Rebels vs Tulane Green Wave Picks and Predictions September 20th 2025

Ole Miss Rebels vs Tulane Green Wave September 20th 2025

The Tulane Green Wave will take on the Ole Miss Rebels in Week 4 of the 2025 regular season. The game will be held at Vaught-Hemingway Stadium in Oxford, Mississippi. Fans can catch the action on ESPN at 3:30 PM on Saturday, September 20, 2025.

Both teams enter this game with a perfect 3-0 record. Tulane has shown strength on the road with a 1-0 away record. Ole Miss, ranked #13 in the AP Poll and #11 in the Coaches Poll, has maintained a strong home record of 2-0. The Rebels also have a 2-0 record in conference play, adding to the anticipation for this matchup.

Tulane vs Ole Miss CFB Key Information

• Sport: College Football
• Teams: Tulane Green Wave vs. Ole Miss Rebels
• Venue: Vaught-Hemingway Stadium, Oxford, MS
• Date: Saturday, September 20, 2025
• Betting Odds: Tulane Moneyline +310, Ole Miss Moneyline -398, Tulane Spread +10.5 (-110), Ole Miss Spread -10.5 (-110), Total Over 61.5 (-104), Total Under 61.5 (-116)

No. 13 Ole Miss set for test vs. unbeaten Tulane

The Ole Miss Rebels return home ranked 13th in the nation and potentially back at full strength under center, with Austin Simmons expected to start after missing time with an ankle injury. They’ll host the Tulane Green Wave, who have opened 3-0 behind late-arriving transfer quarterback Jake Retzlaff. Both teams are unbeaten, and with Tulane lurking just outside the Top 25, this matchup in Oxford could have major implications for bettors tracking college football picks.

Betting Odds and Trends

The Tulane Green Wave Can Win If…

The Tulane Green Wave must continue riding Jake Retzlaff’s hot hand. The transfer quarterback has already proven his dual-threat value, throwing for 270 yards against Duke while adding 111 rushing yards and a school-record four touchdowns on the ground. His ability to extend plays and avoid turnovers gives Tulane an edge against aggressive defenses.

The Green Wave’s rushing attack has been steady, ranking 19th nationally with 670 yards. Running backs Zuberi Mobley and Javin Gordon complement Retzlaff, combining for over 200 yards and multiple scores. Controlling the clock and moving the chains — Tulane ranks 19th in first downs — will be critical to limiting Ole Miss’ possessions.

Defensively, Tulane showed it can generate key turnovers by sealing the win against Duke with a late interception. Replicating that opportunistic play and forcing Simmons or Chambliss into mistakes is the best chance for Tulane to keep the Rebels from finding rhythm at home.

The Ole Miss Rebels Can Win If…

The Ole Miss Rebels need Austin Simmons to settle in quickly after injury. The freshman has 992 passing yards and seven touchdowns in three games but also struggled with turnovers against Kentucky. With Simmons expected back, Ole Miss regains balance and explosiveness through the air.

Kewan Lacy has been a workhorse, rushing for 290 yards with five touchdowns. Even when Arkansas stacked the box last week, Lacy still provided valuable production in yards after contact. If he forces Tulane to respect the run, Simmons will have more opportunities to hit receivers like Harrison Wallace III, who already has 339 yards this season.

Defensively, Ole Miss must focus on containing Retzlaff outside the pocket. Tulane thrives when Retzlaff improvises, and forcing him into quick decisions could create turnovers. With Lane Kiffin’s aggressive play-calling and home-field advantage, the Rebels are positioned to overpower Tulane if they avoid early miscues.

The Lean

Tulane has been an ATS darling on the road, covering in 75% of its last 20 away games, and catching double digits here feels valuable. Ole Miss is deeper and more explosive, but Tulane’s defense and dual-threat quarterback make them a live underdog. The projection of Ole Miss 35, Tulane 28 suggests taking Tulane +10.5.

The total at 61.5 points leans over. Both offenses are efficient — Ole Miss ranks 13th nationally in scoring and Tulane can grind out long drives while still striking big. The model projects 63 points, making the over a strong option for bettors.

Game Preview Recap

Ole Miss enters 3-0 despite juggling quarterbacks, and Lane Kiffin expects Austin Simmons back under center after missing last week. Simmons’ health will dictate the Rebels’ ability to stretch the field and fully deploy their balanced offense.

Tulane’s Jake Retzlaff has been the breakout story of the young season, taking over in July and immediately lifting the Green Wave to three straight wins, including a signature victory over Duke. His combination of accuracy and mobility has made Tulane a dangerous opponent.

This game represents a major measuring stick for Tulane, who is seeking to crash the CFP conversation from the Group of 5. For Ole Miss, it’s about building momentum in the SEC with Simmons returning. The last time these programs met, Ole Miss dominated — but this version of Tulane is far more dangerous.

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