Ole Miss Rebels vs Tulane Green Wave Picks and Predictions December 20th 2025

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Ole Miss Rebels vs Tulane Green Wave Betting Preview

Ole Miss Rebels enter the College Football Playoff with a new head coach in Pete Golding, while Tulane Green Wave play their final game under Jon Sumrall before his move to Florida. Ole Miss boasts an 11-1 record and a perfect home slate, while Tulane arrives at 11-2 with momentum from their American Conference title.

Line Movement and Odds

Ole Miss opened as a heavy favorite at -17.5, with market support holding steady. Public lean favors the Rebels, but Tulane’s ATS record as an underdog has drawn sharp interest.

  • Ole Miss Spread: -17.5 (-109)
  • Tulane Spread: +17.5 (-111)
  • Ole Miss MoneyLine: -927
  • Tulane MoneyLine: +605
  • Total: 56.5 (-110)

For broader market context, check the latest college football odds page.

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Matchup Breakdown

Ole Miss Outlook

QB Trinidad Chambliss leads the Rebels with over 3,700 passing yards, supported by RB Kewan Lacy’s 1,279 rushing yards and 20 touchdowns. Ole Miss ranks top-five nationally in passing and first downs, while their defense sits top-10 in interceptions. Home-field dominance adds another edge.

Tulane Outlook

QB Jake Retzlaff has thrown for 2,862 yards, while RB Javin Gordon adds balance with 500+ rushing yards. Tulane’s defense ranks top-10 in sacks and top-five in fumble recoveries, giving them disruptive potential. Special teams are a strength with kicker Patrick Durkin converting 24 of 27 field goals.

Key Matchup / Path to Victory

The game hinges on Tulane’s ability to slow Chambliss and Lacy while forcing turnovers. Ole Miss must protect the ball and exploit Tulane’s secondary. Tempo and red-zone efficiency will dictate whether Tulane can stay inside the number.

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Injuries / Availability

Ole Miss lists CB Antonio Kite and LB Raymond Collins as questionable.

Tulane has multiple starters out or questionable, including TE LeRon Husbands, QB Brendan Sullivan, and RB Maurice Turner.

Environment

Vaught-Hemingway Stadium provides Ole Miss with one of the strongest home-field advantages in college football. Tulane faces a significant road challenge, while Ole Miss’s offensive tempo and crowd support could push pace higher. Weather conditions are stable, keeping execution clean.

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Best Bets and Prediction

Projected Final Score: Ole Miss 34, Tulane 21

  • Tulane +17.5 → Best Bet. Strong ATS record as underdog and defensive disruption give them cover potential.
  • Under 56.5 → Playable. Both defenses can limit scoring efficiency, keeping the total slightly below the line.

Expect Ole Miss’s depth and talent to secure the win, but Tulane’s resilience keeps the margin inside the spread. The projected score supports the underdog cover and a lean to the under.

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