South Florida Bulls vs Old Dominion Monarchs Picks and Predictions December 17th 2025

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South Florida Bulls vs Old Dominion Monarchs Betting Preview

South Florida Bulls enter the Cure Bowl looking for their 10th win, but the Bulls will lean on backup QB Gaston Moore instead of standout Byrum Brown. Old Dominion Monarchs also turn to a backup, Quinn Henicle, after losing Sun Belt Offensive Player of the Year Colton Joseph. Both teams face similar quarterback transitions, setting up a matchup defined by depth and adaptability.

Line Movement and Odds

Opening line favored South Florida at -5.5, with current market holding steady. Public lean tilts toward the Bulls, but sharp bettors have shown interest in Old Dominion’s underdog track record.

  • South Florida Spread: -5.5 (-110)
  • Old Dominion Spread: +5.5 (-110)
  • South Florida MoneyLine: -221
  • Old Dominion MoneyLine: +181
  • Total: 55.5 (-110)

For broader market context, check the latest college football odds page.

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Matchup Breakdown

South Florida Outlook

The Bulls rank top-15 nationally in scoring and rushing yards, but Moore’s limited reps add uncertainty. WR Keshaun Singleton remains the primary weapon, and RB Nykahi Davenport provides balance. Defensive strength lies in pressure and turnover creation, though secondary depth is tested by injuries.

Old Dominion Outlook

Henicle’s dual-threat ability mirrors Joseph’s style, giving the Monarchs continuity. RB Trequan Jones and WR Tre’ Brown III headline a balanced attack. Defensively, ODU ranks top-10 in sacks, a key edge against a reshuffled USF offensive line.

Key Matchup / Path to Victory

The game hinges on QB efficiency under pressure. South Florida must protect Moore and lean on its run game, while Old Dominion’s defensive front aims to disrupt rhythm. Tempo and red-zone execution will decide the margin.

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Injuries / Availability

South Florida has multiple starters questionable, including OL Derek Bowman and WR Chas Nimrod. Cartevious Norton (RB) and Boogsie Silvera (DB) are out.

Old Dominion will be without LB Jason Henderson, while several starters across OL and secondary remain questionable.

Environment

Neutral-site in Orlando favors neither side, but South Florida benefits from reduced travel. Both teams play at high tempo, suggesting pace will push the total upward. Weather conditions are stable, minimizing external impact.

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Best Bets and Prediction

Projected Final Score: South Florida 31, Old Dominion 27

  • Old Dominion +5.5 → Best Bet. Strong ATS record as underdog and QB mobility give them cover potential.
  • Over 55.5 → Playable. Both offenses can generate explosive plays, and defensive injuries tilt toward points.

Expect a competitive game with South Florida’s depth edging out late, but Old Dominion’s resilience keeping it inside the number. The over aligns with tempo and offensive efficiency trends.

Handicappers and Service Plays

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