Texas Tech Red Raiders vs Oklahoma State Cowboys Picks and Predictions October 25th 2025

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Oklahoma State Cowboys vs Texas Tech Red Raiders Game Preview

The Oklahoma State Cowboys head south to face the Texas Tech Red Raiders on Saturday, October 25, 2025, at Jones AT&T Stadium in Lubbock, TX. Kickoff is scheduled for 4:00 PM ET on ESPN.

No. 14 Texas Tech (6-1, 3-1 Big 12) returns home following its first loss of the season, a 26-22 defeat at Arizona State. The Red Raiders aim to reestablish their ground game and stay perfect in Lubbock. Meanwhile, Oklahoma State (1-6, 0-4 Big 12) continues to search for its first conference win under interim coach Doug Meacham after six consecutive losses.

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Line Movement and Betting Odds

Oklahoma State Moneyline: +1600
Texas Tech Moneyline: -4200
Oklahoma State Spread: +38.5 (-110)
Texas Tech Spread: -38.5 (-110)
Total Over/Under: 56.5 (-110)

Oddsmakers list Texas Tech as one of the week’s largest favorites. The Red Raiders’ top-15 ranking and perfect home record have bettors heavily leaning toward the favorite, while the total reflects the potential for offensive fireworks.

Find model projections and verified betting trends in the college football picks section.

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Oklahoma State Cowboys

Oklahoma State’s season has spiraled since the firing of longtime coach Mike Gundy in late September. The Cowboys are still winless in Big 12 play after a 49-17 home loss to Cincinnati last week — their sixth straight defeat.

Despite the struggles, running back Rodney Fields Jr. has emerged as a bright spot, rushing for 163 yards and a touchdown against the Bearcats. He leads the team with 420 yards on the season. Interim coach Doug Meacham has also experimented at quarterback, with Sam Jackson V — a converted receiver — now under center. Jackson passed for 149 yards against Cincinnati and continues to use his mobility to extend plays.

Oklahoma State’s defense has been opportunistic at times, recording three interceptions and three fumble recoveries this season. Special teams have also been steady, with kicker Logan Ward hitting 11 field goals, ranking 22nd nationally.

Injury Report

Markell Samuel (OL) – Questionable (Undisclosed)
Da’Wain Lofton (WR) – Questionable (Undisclosed)
DeAndre Boykins (S) – Questionable (Undisclosed)
Jaylin Davies (CB) – Questionable (Undisclosed)
JK Johnson (CB) – Questionable (Undisclosed)
Kale Smith (CB) – Questionable (Undisclosed)
Jaleel Johnson (DE) – Questionable (Undisclosed)
Talyn Shettron (WR) – Out (Knee)
Louie Canepa (OL) – Questionable (Undisclosed)
Darius Thomas (LB) – Questionable (Undisclosed)
Dylan Smith (S) – Questionable (Undisclosed)
Zane Flores (QB) – Questionable (Undisclosed)

Full injury report for Oklahoma State Cowboys

Texas Tech Red Raiders

Texas Tech’s 26-22 loss at Arizona State snapped its unbeaten start, and coach Joey McGuire emphasized a renewed focus on the running game after producing just 109 rushing yards. Backup quarterback Will Hammond filled in for injured starter Behren Morton, throwing for 167 yards and two touchdowns.

Morton remains day-to-day with a leg injury and could return this week, which would provide a major boost for the Red Raiders’ offense. When healthy, he’s thrown for 1,501 yards and 13 touchdowns this season.

The Red Raiders still boast elite production despite the loss. They rank third nationally in points scored (307) and top 10 in first downs (174). Their defense has been equally impressive, ranking fourth nationally with 25 sacks. With a balanced attack and a deep defensive front, Texas Tech remains a strong contender for a New Year’s Six bowl.

Injury Report

Roy Alexander (WR) – Questionable (Undisclosed)
Davion Carter (DL) – Questionable (Foot)
Skyler Gill-Howard (DL) – Out (Leg)
Miquel Dingle Jr. (LB) – Out (Leg)
T.J. West (TE) – Questionable (Undisclosed)
Chapman Lewis (DB) – Questionable (Undisclosed)
Quinten Joyner (RB) – Out (Knee)
Tarrion Grant (CB) – Questionable (Undisclosed)
Dylan Singleton (WR) – Out (Undisclosed)

Full injury report for Texas Tech Red Raiders

Key Storylines

• Texas Tech ranks third nationally in scoring (307 points) and fourth in sacks (25).
• Oklahoma State has dropped six straight games and remains winless in Big 12 play.
• Red Raiders quarterback Behren Morton remains day-to-day with a leg injury.
• Cowboys running back Rodney Fields Jr. leads the team with 420 rushing yards.
• Texas Tech is undefeated at home this season and 19-5 at Jones AT&T Stadium since 2022.

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Prediction

Texas Tech should control this matchup from the outset, regardless of who starts at quarterback. Oklahoma State’s offense remains inconsistent, while the Red Raiders’ defense and home dominance give them a clear edge. Expect a comfortable Texas Tech win and plenty of scoring on both sides.

Projected Score: Texas Tech 55, Oklahoma State 10
Best Bet: Texas Tech -38.5 (-110)
Secondary Lean: Over 56.5 (-110)

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