Usc Trojans vs Georgia Southern Eagles Picks and Predictions September 6th 2025

USC vs Georgia Southern Picks and Predictions

Saturday’s game at the Los Angeles Memorial Coliseum is more than just a Week 2 matchup—it’s a reunion. Georgia Southern head coach Clay Helton returns to the field he once called home as he leads the Eagles against his former team, the USC Trojans.

Helton served as USC’s head coach from 2015 to 2021, compiling a 46-24 record with a Rose Bowl win in 2017 and a conference title. But after falling short of lofty expectations, he was let go just four years ago following a loss to Stanford.

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Now in his fourth year with Georgia Southern, Helton brings a program seeking redemption after a blowout Week 1 loss.

Game Context and Stakes

USC (1-0) is flying high after obliterating Missouri State 73-13 in their opener. It was the first time in two decades the Trojans scored over 70 points. Georgia Southern (0-1), on the other hand, struggled in a 42-14 road loss to Fresno State. This is their second straight game in California, and the challenge only grows steeper.

If you’re considering betting on this game, visit the latest College Football Picks and check the updated NCAAF Odds to guide your selections.

Key Matchups

Quarterback Jayden Maiava was nearly flawless, going 15-for-18 for 295 yards and two touchdowns in just over two quarters. He also rushed for a score, adding to USC’s six total rushing touchdowns in Week 1.

Backup Husan Longstreet didn’t miss a beat, running for two touchdowns himself. The depth of USC’s offensive unit is becoming a major storyline.

Georgia Southern’s Growing Pains

Despite their 42-14 defeat, quarterback JC French IV showed potential. He passed for 158 yards and two touchdowns before halftime, drawing praise from Helton for his maturity and poise.

But the team’s second-half collapse—surrendering 29 unanswered points—revealed some serious defensive vulnerabilities.

Tale of the Tape

Emotional and Tactical Factors

Helton’s return adds emotional weight to the game, but sentimentality won’t slow USC’s firepower. Head coach Lincoln Riley spoke highly of Helton earlier this week, describing their interactions as positive and respectful. However, Riley and the Trojans are locked in on maintaining momentum after such a dominant opener.

Betting Predictions

This game offers several intriguing lines for bettors. USC is expected to be a heavy favorite, and rightly so. The bigger question may be whether Georgia Southern can cover the spread or keep it respectable in the second half.

Picks Table

Before placing your bets, be sure to check our Expert NFL Betting Guide for strategy tips that apply to both college and pro levels.