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Colorado Buffaloes vs Utah Utes Game Preview
The Colorado Buffaloes travel to face the Utah Utes at Rice-Eccles Stadium in Salt Lake City on Saturday, October 25, 2025. Kickoff is scheduled for 10:15 PM ET on ESPN.
Utah (5-2, 2-2 Big 12) looks to recover from a 24-21 loss to rival BYU, while Colorado (3-4, 1-3 Big 12) enters fresh off a bye after a statement win over then-No. 22 Iowa State. Both teams are hunting for bowl eligibility in a competitive Big 12 field.
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Line Movement and Betting Odds
Colorado Moneyline: +402
Utah Moneyline: -547
Colorado Spread: +13.5 (-110)
Utah Spread: -13.5 (-110)
Total Over/Under: 49.5 (-110)
Utah opened as a two-touchdown favorite at home, though quarterback uncertainty has slightly tightened the line. Colorado’s offense has improved under Kaidon Salter, but the Utes’ defensive depth and home-field advantage keep them firmly favored.
Full projections and betting trends are available in the college football picks section.
Colorado Buffaloes
Colorado used its bye week to regroup after pulling off a 24-17 upset of ranked Iowa State. Quarterback Kaidon Salter delivered one of his most composed performances of the season, throwing for 255 yards and two touchdowns without an interception.
The Buffaloes’ defense was equally impressive, holding the Cyclones to 17 points and generating key stops late. That effort highlighted a defensive unit that ranks top 25 nationally in both sacks and interceptions, a major improvement under Deion Sanders’ revamped system.
Receiver Omarion Miller remains Salter’s top target, recording 371 receiving yards and four touchdowns this season. Colorado’s offense averages 24.8 points per game, and its ability to protect the ball will be critical against a Utah defense known for capitalizing on turnovers.
Injury Report
Tyler Brown (G) – Questionable (Undisclosed)
Sav’ell Smalls (TE) – Questionable (Undisclosed)
Arden Walker (DE) – Questionable (Undisclosed)
Simeon Price (RB) – Questionable (Undisclosed)
Jack Hestera (WR) – Questionable (Undisclosed)
Samuel Okunlola (DE) – Questionable (Undisclosed)
Tawfiq Thomas (DT) – Questionable (Undisclosed)
Tavian Coleman (DT) – Questionable (Undisclosed)
Gavriel Lightfoot (DT) – Questionable (Undisclosed)
Phillip Houston (OT) – Questionable (Undisclosed)
DeKalon Taylor (RB) – Questionable (Undisclosed)
Carter Stoutmire (S) – Questionable (Undisclosed)
Full injury report for Colorado Buffaloes
Utah Utes
Utah’s 24-21 loss to BYU came with a cost as quarterback Devon Dampier suffered an ankle injury that has his status in doubt for this week. If he’s unable to play, freshman Byrd Ficklin will make his first career start. Ficklin has been perfect in limited duty, completing all nine of his pass attempts for 138 yards and a touchdown, while rushing for 111 yards and three scores.
The Utes remain among the most balanced teams in the Big 12, ranking seventh nationally in rushing yards (1,720) and fifth in first downs (181). Their defense continues to set the tone, ranking 11th in sacks (18) and seventh in interceptions (6).
Even with a possible quarterback change, coach Kyle Whittingham’s formula remains the same — physical defense, ball control, and efficient red-zone execution. Utah has won six straight home meetings against Colorado dating back to 2013.
Injury Report
Nate Ritchie (S) – Questionable (Undisclosed)
Paul Fitzgerald (DE) – Questionable (Undisclosed)
Devon Dampier (QB) – Questionable (Ankle)
Daidren Zipperer (WR) – Out (Undisclosed)
Hunter Andrews (TE) – Out (Undisclosed)
Isaiah Garcia (OL) – Questionable (Undisclosed)
Rabbit Evans (S) – Out (Undisclosed)
Grady Mareko (LB) – Questionable (Undisclosed)
Josh Sovereign (S) – Questionable (Undisclosed)
Full injury report for Utah Utes
Key Storylines
• Utah may start freshman QB Byrd Ficklin if Devon Dampier is unavailable.
• Colorado snapped its seven-game losing streak to Utah with a 49-24 win last season.
• The Buffaloes’ defense ranks top 25 nationally in sacks and interceptions.
• Utah’s defense is allowing just 15.3 points per game at home.
• Colorado has lost six straight games in Salt Lake City dating back to 2013.
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Prediction
Even with questions under center, Utah’s home-field advantage and physical defense should be enough to handle a streaky Colorado team. Expect the Utes to rely on their run game and defensive line to wear down the Buffaloes over four quarters.
Projected Score: Utah 31, Colorado 14
Best Bet: Utah -13.5 (-110)
Secondary Lean: Under 49.5 (-110)
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