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Green Bay Packers vs Arizona Cardinals Betting Preview
The Green Bay Packers head west to face the Arizona Cardinals in a Week 7 NFC showdown at State Farm Stadium. Kickoff is set for Sunday, October 19, 2025, at 4:25 PM ET on FOX.
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Green Bay (3-1-1) has been solid at home but still searches for its first road victory of the year. Arizona (2-4) has dropped four straight, each by single digits, and enters this matchup desperate to turn things around. With uncertainty surrounding the Cardinals’ quarterback situation — Kyler Murray or Jacoby Brissett — this game’s line movement could fluctuate all week on the NFL odds board.
For bettors following both the matchup and team metrics, the NFL Expert Betting Guide offers breakdowns of public splits and power rankings updated daily.
Line Movement and Odds
The Packers opened as 6.5-point favorites, holding a moneyline of -321, while the Cardinals sit at +258. The total is set at 44.5 points, with slight movement toward the over due to both teams’ ability to sustain long drives.
Green Bay ranks among the NFL’s top 10 in rushing and total defense, while Arizona continues to rely on explosive moments from its quarterbacks and tight ends. Early sharp money has backed Green Bay, but Arizona’s recent ATS trends at home could keep this line tight until kickoff.
Monitor real-time shifts through the NFL picks and betting section to track updates across sportsbooks.
Matchup Breakdown
The Packers’ 27-18 victory over Cincinnati last week showcased a complete team effort. Running back Josh Jacobs led the ground game with 93 yards and two scores, while Jordan Love delivered a balanced performance with 259 passing yards and a touchdown. Green Bay’s offensive rhythm has improved steadily, ranking 5th in rushing and 6th in scoring defense.
Defensively, Green Bay’s front seven has thrived under LaFleur’s aggressive play-calling. With Lukas Van Ness and Devonte Wyatt managing injuries, the Packers may rely more heavily on Kenny Clark and Rashan Gary to pressure Arizona’s quarterback — whoever starts.
For the Cardinals, Jacoby Brissett threw for 320 yards and two touchdowns in a narrow loss to Indianapolis, proving capable in Kyler Murray’s absence. Tight end Trey McBride has emerged as a go-to target, while rookie Marvin Harrison Jr. (concussion protocol) could return to add explosive potential.
Arizona’s biggest concern remains on defense. The unit has allowed over 27 points per game and struggles against the run — an issue Green Bay’s ground game will exploit.
If Murray plays, expect the line to tighten slightly, as his dual-threat presence changes the Cardinals’ offensive ceiling. Either way, the Packers’ balance and depth make them the more complete team heading into this matchup.
You can explore more team insights and matchup data in the Super Bowl odds and predictions blog, where both franchises’ playoff probabilities are updated weekly.
Injuries and Conditions
Green Bay Packers:
Brandon McManus (Quad) Questionable, Jayden Reed (Collarbone) Out, Christian Watson (Knee) Questionable, Lukas Van Ness (Foot) Questionable, Devonte Wyatt (Knee) Questionable, MarShawn Lloyd (Hamstring) Out, Travis Glover (Shoulder) Out.
Arizona Cardinals:
Kyler Murray (Foot) Questionable, Marvin Harrison Jr. (Concussion) Questionable, James Conner (Foot) Out, L.J. Collier (Knee) Out, Sean Murphy-Bunting (Knee) Out, J.J. Russell (Concussion) Out, Trey Benson (Knee) Out.
Both teams are banged up, but Green Bay’s offensive core remains intact. Arizona’s health on offense — particularly at quarterback — could dictate the game’s tempo and betting direction.
Best Bets and Prediction
The Packers’ consistency in the run game and defense gives them a clear edge over an Arizona team still trying to find its identity. Jordan Love’s improved decision-making and Josh Jacobs’ power running should control possession and limit Arizona’s chances.
If Murray starts, Arizona can keep it competitive with his mobility and playmaking. If not, Brissett’s steady hand will need near-perfect execution to keep pace with Green Bay’s balanced attack.
Projected Score: Packers 28, Cardinals 17
Best Bet: Packers -6.5 (-111)
Secondary Lean: Over 44.5 (-107)
To compare consensus predictions and live props, visit the NFL betting picks section or explore player projection data through the NFL odds hub for in-game opportunities.
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