Buffalo Bills vs. Detroit Lions Pick & Prediction NOVEMBER 24th 2022

Stadium: Ford Field Detroit
Logo Buffalo Bills
Logo Detroit Lions

-10 +103
50.5o -110



The Buffalo Bills are one of the best teams in the NFL this season. Even after a few uncharacteristic losses, they were able to bounce back last week. After a 31-23 win over the Cleveland Browns, they’ll look to earn another one this week. Although they’re favored by a lot, they shouldn’t underestimate Detroit on Thursday.

The Detroit Lions are coming off a 31-18 win over the New York Giants. This marked the third straight win for the 4-6 Lions. This week, they’ll face a very tough opponent and come in as heavy underdogs. However, just because they’re not favored doesn’t mean they can’t cover the spread. Let’s take a look at the odds and information on each team before choosing.

Bills vs. Lions Odds


MONEY LINE: Bills (-420) vs. Lions (+330)

SPREAD: Bills -9.5 (-105) vs. Lions +9.5 (-115)

GAME TOTAL: Over 53.5 (-115) vs. Under 53.5 (-105)

Bills vs. Lions Preview, Trends and Stats

As an offense, the Buffalo Bills rank second in the NFL in points per game. On average, the Bills are scoring 28.1 points per game; this offense will be on display once again. The good news for the Bills is they shouldn’t run into much opposition when they face the Lions.

Last week, in their win over the Cleveland Browns, the Buffalo Bills put up 18 points in the second half. From the five-minute mark in the second quarter, until the 4:11 mark in the fourth, they were the only team to score. This amount of control over the clock is why they win.

The Bills defense will also be responsible for controlling the game. This season, the Buffalo Bills are allowing just 17.4 points per game, ranking fourth overall. This kind of hard-nosed defense puts them at the top of the league and helps them cover spreads.

The Detroit Lions come into this game as heavy underdogs. However, it’s important to note that oftentimes the Lions have done well against the spread. They were underdogs last week when they faced the Giants and came away with a win.

With three straight wins under their belt, they’ll try to beat one of the best teams in the league. Doing this will require the Lions to get the Bills offense off the field as quickly as possible. The problem with this is they don’t have a very good defense.

Bills vs. Lions Picks

This game is going to be a tough one for the Detroit Lions. Although they’ve won their last three games, they’ve yet to face a team as good as the Bills. Due to this, even with the large spread, we can’t take them at home.

We’re going to take the Buffalo Bills at -9.5 over the Detroit Lions. They have a history of putting up a lot of points and we think they’ll do so again here. They also have a stingy defense that should prevent the Lions from scoring.

Final Score: 32-20 (Bills)


1. The total has gone under in six of Buffalo's last eight games.

2. The Buffalo Bills are 5-1 in their last six games against the Lions.

3. The Bills are 5-4-1 against the spread this season.

Best Bet: Bills -9.5 (-105) and Under 53.5 (-105)

Buffalo Bills
Detroit Lions

Buffalo Bills vs. Detroit Lions

The Lions lost their preseason game Friday, 24-20 to the visiting Buffalo Bills, but of bigger concern to Detroit was the loss of two players to right leg injuries.

Linebacker Jarrad Davis got hurt on the second play from scrimmage. He was tripped up by a teammate, linebacker Devon Kennard, as they pursued a Buffalo ball-carrier. Davis was helped off the field, then driven to the locker room on a cart.

In the second quarter, Lions center Frank Ragnow had his leg rolled over by a Bills player. He also was assisted from the field.

As for the game action, Bills quarterback Josh Allen played the first half and guided two touchdown drives. He completed 3 of 6 passes for 49 yards. Matt Barkley went 12 of 14 for 142 yards and a touchdown off the bench.

Lions quarterback Matthew Stafford was in for the majority of the first half, and he threw an 11-yard touchdown pass to Ty Johnson. Stafford finished 12 of 19 for 137 yards.

--Field Level Media