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Arizona Cardinals vs. San Francisco 49ers Pick & Prediction NOV 7TH 2021

Logo Arizona Cardinals
Logo San Francisco 49ers

46.5o -110
-7.5 +145



The Arizona Cardinals took their first loss of the season last week when they faced the Packers. Now, they’ll head to San Francisco to take on one of their division rivals, the 49ers. With the race to the playoffs heating up, the Cardinals want to put another strike in the win column. They’ve already beaten the 49ers once. Can they do it again but this time on the road?

The San Francisco 49ers finally got a win after four losses in a row. Their win over the Chicago Bears brought them to a 3-4 record, third in the NFC West. Unfortunately for them, they’ve been dealt a blow by having to face the Cardinals on Sunday. Considering their defense is one of the worst against mobile quarterbacks, are the Niners a realistic pick to win here?

Cardinals vs. 49ers Odds for Week 9


MONEY LINE: Cardinals (-140) vs. Niners (+120)

SPREAD: Cardinals -2.5 (-110) vs. Niners +2.5 (-110)

GAME TOTAL: Over 45 (-110) vs. Under 45 (-110)

Cardinals vs. 49ers Betting Trends and Preview

The Cardinals easily have one of the best offenses in the NFL. However, this offense was slowed to a stop when they faced the Green Bay Packers last week. To put that behind them, they’ll need to get a huge win over a division rival on Sunday. Even with the loss, the Cardinals are one of the best in the NFL and can display that in Week 9.

We’re sure that Kyler Murray had words with his wide receiving group about the importance of communication. The Cardinals average 264.88 passing yards per game, and a healthy amount of communication is needed for that. They’re going against a strong passing defense, so they’ll need to be on the same page Sunday.

The Niners season has been a tumultuous one, a roller coaster ride. They started the season 2-0 but followed that with four straight losses. Now that they’ve finally broken their losing streak, they face one of the toughest teams in the NFL. The key for the Niners here is to keep everything in front of them.

Along with that, containing Kyler Murray and puts pressure on him. Murray is listed as “questionable” for this game, so keep an eye on that when betting. DeAndre Hopkins is on the injury list, so confirm these two are playing before you bet. The last thing you would want is to bet on the Cardinals and those two being out of the lineup.

Cardinals vs. 49ers Predictions

Cardinals 24 - 49ers 20

A quick look at the injury report makes this one a tough game for bettors. On each side of the ball, there are a ton of injuries. However, the injuries to the Cardinals are a lot more drastic. If the Cardinals are without Kyler Murray, they’ll be starting Colt McCoy. If both Murray and Hopkins are out, it’ll be a tough game for the Cardinals to win.

The 49ers have injuries as well, mainly to Dee Ford and Jimmie Ward. When placing a bet on this one, you should wait until the injury list is finalized and you know who is playing. Without that information, we’d say the Cardinals on the road are the better pick, based on previous performances.


1. Arizona is 5-1 ATS in their last six games.

2. The Cardinals are 2-1 against the 49ers in their previous three games.

3. In each of their previous three games against each other, the total has gone UNDER.

Best Bet: Arizona Cardinals -2.5

Arizona Cardinals
San Francisco 49ers

Arizona Cardinals vs. San Francisco 49ers

Kyler Murray ran for a game-high 91 yards, threw for 230 and accounted for two touchdowns Sunday afternoon, and the Arizona defense stopped a San Francisco 49ers' red-zone drive in the final minute as the visiting Cardinals stunned the defending NFC champions 24-20 in the opener for both teams.

DeAndre Hopkins turned a career-high 14 catches into 151 yards as the Cardinals (1-0) rallied to win.

Kenyan Drake scored on a 1-yard run for the winning score with 5:03 to go after the teams traded leads three times over a stretch of just over five minutes.

Murray began an Arizona comeback from an early 10-0 deficit with a 10-yard touchdown pass to Chase Edmonds, then gave the Cardinals their first lead at 17-13 on a 22-yard TD run with 10:26 to go.

After the teams combined for just two field goals in the second quarter and didn't score at all in the third, the offenses ramped it up in the fourth period in rapid-fire action.

Down by three, the Cardinals began the back-and-forth on Murray's 22-yard scamper.

Benefiting from a pass-interference call that negated a Chris Banjo interception, it took the 49ers (0-1) just 1:48 to regain the lead on Jerick McKinnon's 5-yard reception from Jimmy Garoppolo.

For McKinnon, it was his first score since December of 2017, when he played for Minnesota. He joined the 49ers as a free agent that off-season, then blew out his knee in the 2018 preseason and hadn't played since.

But back came the Cardinals again, this time getting the 1-yard plunge from Drake one play after an apparent 34-yard touchdown pass to Hopkins was reviewed and placed at the 1. Drake's score came with 5:03 remaining and put Arizona back on top 23-20 before the extra point.

The 49ers then drove 59 yards to the Arizona 16, but the Cardinals' Patrick Peterson and Byron Murphy Jr. had key pass break-ups, forcing San Francisco to turn the ball over on downs with just 33 seconds left.

The 49ers never trailed in the first half but went into halftime concerned that star tight end George Kittle had injured his knee on a catch attempt late in the second period.

Kittle was able to walk off the field, and to the locker room, under his own power. He returned to play in the second half but finished with just four catches for 44 yards.

Murray finished 26-for-40 with one interception. He had a 100-yard rushing day before taking negative yardage while running out the clock.

Raheem Mostert led the 49ers in both receiving (95) and rushing (56) yards, with 76 of the receiving yards coming on a first-quarter catch-and-run for San Francisco's first touchdown.

Garoppolo wound up 19 for 33 for 259 yards and two touchdowns.

--Field Level Media

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