Lucas Oil Stadium Indianapolis

Kansas City Chiefs vs. Indianapolis Colts Pick & Prediction SEPTEMBER 25th 2022

Logo Kansas City Chiefs
Logo Indianapolis Colts

-5.5 +100
50.5o -110



The Kansas City Chiefs have had a fast start to the season, going 2-0 so far. They’ve had two big wins, one over the Arizona Cardinals and the Los Angeles Chargers. Last week, they took down the Chargers 27-24 in a close game. As they lead the AFC West, the Chiefs head back on the road to face the Indianapolis Colts. It’s no surprise that the Chiefs are 6.5-point favorites.

The Indianapolis Colts have an 0-1-1 record this season after last week’s loss. Matt Ryan has looked awful so far this season, throwing several interceptions. They were shut out 24-0 in a week 2 loss to the Jacksonville Jaguars, an embarrassing defeat. Now, they’ll face one of the best offenses in the NFL. Do the Indianapolis Colts have a chance to win this game?

Chiefs vs. Colts Odds


MONEY LINE: Chiefs (-267) vs. Colts (+227)

SPREAD: Chiefs -6.5 (-110) vs. Colts +6.5 (-110)

GAME TOTAL: Over 49.5 (-110) vs. Under 49.5 (-110)

Chiefs vs. Colts Preview (NFL Week 3)

The Kansas City Chiefs are on a roll this season, starting fast with two straight wins. In week 2, Patrick Mahomes passed for 235 yards and two touchdowns. This was a tight game until the fourth quarter, which is when the Chiefs broke away. The final score ended 27-24 for the Chiefs.

This season, Mahomes has thrown for nearly 600 yards and seven touchdowns. Perhaps the most impressive feat is that he hasn’t turned the ball over once. Averaging 35.5 points per game, the Chiefs are well-equipped to win this game, regardless of them being on the road.

One way they can beat the Colts is by putting pressure on Matt Ryan. Ryan has never been a mobile quarterback and age definitely hasn’t helped him. Putting a few bodies on Ryan will help them pull off a win on the road. The truth is, the Colts offense can’t keep up with the Chiefs.

The Colts started the season with a 20-20 tie to the Houston Texans. They followed it up with a 24-0 loss to the Jacksonville Jaguars. There are a few people that you could blame this game on, but mainly, it’s Matt Ryan. Instead of protecting the football, he turned it over several times.

Last week, Ryan went 16/30 with 195 yards and three interceptions. They failed to score a single point and the offense had the ball for only 21:45. This awful performance will likely extend into week 3 as they face the Chiefs. The question now is can they cover the spread at home?

In order to make this game competitive, the Chiefs will need to slow down the Chiefs' offense. They can start by shutting down the passing game of Kansas City. Putting pressure on Mahomes will help, but they’ll need to do a lot more than just blitz.

Chiefs vs. Colts Pick

This season, the Kansas City Chiefs have a record of 1-1 against the spread. They covered the spread in week 1 but failed to cover it in week 2. It’s important to remember the differences between these two offenses. The Chiefs average 35.5 points per game, while the Colts average only 10. In terms of points allowed, the Chiefs have allowed 22.5, compared to the Colts’ 22.

The Chiefs don’t have a large spread to cover either, only 6.5-points. Although they’re on the road, the Chiefs are the better option to cover the spread here. Indianapolis was just beaten 24-0 by the Jaguars, who have a much worse offense than the Chiefs.

Final Score: 30-17 (Chiefs)


1. The Chiefs are 9-4 against the spread in their last 13 games.

2. Indianapolis has gone 1-4 against the spread in their last five games.

3. The total has gone UNDER in 5 of Indianapolis' last 6 games against Kansas City.

Best Bet: Kansas City Chiefs -6.5 (-110) and Under 49.5 (-110)

Kansas City Chiefs
Indianapolis Colts
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