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The Syracuse Orange and SMU Mustangs clash Saturday in Dallas, as both programs seek redemption. Syracuse was humiliated 38–3 by Duke and was forced to start Rickie Collins in place of injured starter Steve Angeli. SMU, meanwhile, surrendered two late touchdowns in a 35–24 loss at TCU after leading late. This spot has bounce-back angle and narrative intrigue, and it’s featured in our college football week 6 odds and predictions. SMU is favored by about –4.5 to –5, with the Mustangs priced around –220. Syracuse is the underdog near +180. The total is 48.5, and early leanings favor the under, as bettors expect this to be more defensive or mistake-driven than high-scoring. Syracuse Orange OutlookCollins, in his first career start,

The Illinois Fighting Illini are ranked No. 22 and riding the momentum of a big win over USC, setting the stage for Saturday’s trip to West Lafayette to face the Purdue Boilermakers. Illinois has been explosive offensively, averaging 35.8 points per game, while Purdue enters off a bye looking to reset after consecutive losses to USC and Notre Dame. Fans can compare this matchup with other betting edges in the college football week 6 odds and predictions. Illinois enters as a road favorite at –9.5, with a moneyline around –360. Purdue is priced at +281 as the home underdog. The total is set at 57, signaling oddsmakers expect a game with big plays and scoring runs. Illinois Fighting Illini OutlookQuarterback

The Virginia Cavaliers enter Louisville Saturday ranked No. 24, riding the momentum of a dramatic double-OT win over Florida State. The Louisville Cardinals host their ACC rival with an unblemished 4–0 record, aiming to build a signature win at home. Hurricanes that haunted Virginia last season may have shifted, but Louisville still holds a three-game series edge and plans to step up against a balanced, high-octane offense. You can see where this matchup ranks in the college football week 6 odds and predictions. Want sharper betting insights? See top handicappers and strategy plays → Virginia is currently a modest road favorite at –4.0, though several books opened Louisville +4.5. The Cavaliers are priced around –188 on the moneyline, with the

The Penn State Nittany Lions travel west to face the UCLA Bruins Saturday in a matchup of contrasting trajectories. Penn State dropped a heartbreaking double-overtime game to Oregon, 30-24, after driving the field late and seizing the lead in regulation. Meanwhile, UCLA remains winless (0-4), having already dismissed head coach DeShaun Foster and now under interim leadership. With playoff implications and pride both on the line, this one carries weight beyond just a win-loss. The context and betting dynamics are further detailed in the college football week 6 odds and predictions. Penn State opened as a large favorite and now sits around –21.5 at many books. The Nittany Lions are priced around –950 on the moneyline, with UCLA a long