Miami Dolphins vs Los Angeles Chargers Picks and Predictions October 12th 2025

Miami Dolphins vs Los Angeles Chargers October 12th 2025

The Los Angeles Chargers will visit the Miami Dolphins in Week 6 of the 2025 NFL season. The game will be held at Hard Rock Stadium in Miami Gardens, Florida. Fans can catch the action on CBS at 1:00 PM on Sunday, October 12, 2025.

The Chargers come into this game with a 3-2 record. They have been strong in their division, holding a 3-0 record in the AFC West. The Dolphins, on the other hand, have had a tough start to the season with a 1-4 record. They will look to improve their standing at home, where they are currently 1-1. The weather forecast predicts a mild day with clear skies and a light breeze, setting the stage for an interesting game.

Chargers vs Dolphins Key Information

Sport: Football (NFL)
Teams: Los Angeles Chargers vs. Miami Dolphins
Venue: Hard Rock Stadium in Miami Gardens, FL USA
Date: Sunday, October 12, 2025
Betting Odds: Chargers Moneyline -221, Dolphins Moneyline +184, Chargers Spread -4.5 (-112), Dolphins Spread +4.5 (-109), Total Over 43.5 (-110), Total Under 43.5 (-111)

Chargers vs Dolphins – NFL Week 6 Betting Preview

The Los Angeles Chargers and Miami Dolphins both enter Week 6 desperate to bounce back from blown leads that derailed promising performances.

Los Angeles started 3-0 but has dropped two straight after a 27-10 loss to Washington, while Miami squandered a 17-0 first-half advantage in a 27-24 defeat to Carolina. Both teams are loaded with offensive talent, but execution and consistency have been the missing ingredients.

The Chargers can win if

They keep Justin Herbert upright and disciplined. Herbert has been sacked 16 times this season — tied for third-most in the NFL — and is dealing with an injury-riddled offensive line missing both tackles Rashawn Slater and Joe Alt.

With starting running back Omarion Hampton on injured reserve, the Chargers will need production from Hassan Haskins and Kimani Vidal to sustain drives and balance the offense. Recently signed Nyheim Hines could provide short-yardage and screen help to relieve pressure on Herbert.

Los Angeles’ defense must also re-establish its early-season identity. They’ve allowed 54 points across their last two games after giving up just 33 in the first three. If the front seven, led by Khalil Mack and Joey Bosa, can create disruption and limit Tua Tagovailoa’s rhythm, the Chargers can regain control of their playoff trajectory.

The Dolphins can win if

They protect the ball and establish offensive balance. Even without Tyreek Hill, Miami’s passing game looked rejuvenated last week, with Tua Tagovailoa throwing for 256 yards and three touchdowns. His chemistry with Jaylen Waddle (110 yards, 1 TD) and tight end Darren Waller (78 yards, 1 TD) remains strong.

However, the Dolphins managed just 19 rushing yards against Carolina — a red flag for an offense built on zone-run principles. Expect Raheem Mostert and De’Von Achane to see early touches to control pace and keep the Chargers’ pass rush honest.

Defensively, Miami must improve against the run after surrendering 206 rushing yards to Rico Dowdle. With Los Angeles’ offensive line banged up, this is the perfect chance for Christian Wilkins and Jaelan Phillips to dominate up front and generate turnovers.

Line Movement and Odds

Opening: Dolphins -2.5 / Chargers +2.5
Current: Dolphins -3 / Chargers +3
Total: 47.0 points

Early money has leaned toward Miami at home, though Los Angeles is 4-1 ATS in its last five games as an underdog. The total has hovered around 47 due to both teams’ offensive volatility.

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Matchup Breakdown

Both offenses are capable of 30+ point outings, but protection and turnovers will define this game. The Chargers rank top-10 in passing offense (262.4 YPG) but bottom-five in rushing success rate since losing Hampton.

Miami, meanwhile, ranks 6th in passing touchdowns but has fallen to 22nd in total defense. They’re giving up 142.8 rushing yards per game and have forced just five takeaways all season.

Whichever team limits penalties — Los Angeles ranks 31st in penalty yardage — and converts red-zone chances should prevail in this AFC matchup. Learn more about situational metrics in the Expert Betting Guide or analyze all NFL teams before locking your bets.

Injury Report

Los Angeles Chargers

RB Omarion Hampton (ankle) – IR
OT Rashawn Slater (knee) – out for season
OT Joe Alt (ankle) – questionable
WR Keenan Allen (rest) – probable
LB Bud Dupree (hamstring) – out
WR Derius Davis (knee) – out
OG Trey Pipkins III (knee) – questionable

Miami Dolphins

WR Tyreek Hill (knee) – out for season
QB Tua Tagovailoa (thumb/hip) – probable
DE Jaelan Phillips (ankle) – questionable
TE Darren Waller (rest) – active
CB Cornell Armstrong (hamstring) – IR
OL Lary Borom (thumb) – limited
WR Cedrick Wilson Jr. (knee) – questionable

Weather: 82°F, humid, 11 mph winds — mild passing impact.

Prop Spotlight

Jaylen Waddle Anytime Touchdown (+115)
With Hill sidelined, Waddle is the top red-zone target and has scored in back-to-back games.

Justin Herbert Over 1.5 Passing TDs (-120)
Herbert continues to find ways to move the ball through the air even behind a patchwork offensive line. Miami has allowed multiple passing TDs in four of five games.

Best Bets and Prediction

This game profiles as a shootout between two offenses desperate to reassert dominance. The difference could be Herbert’s poise versus Tagovailoa’s ability to extend plays behind a banged-up line.

Prediction: Dolphins 27, Chargers 24
Best Bet: Chargers +3 (-110)
Secondary Lean: Over 47.0 (-110)

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