NFL Previews 
MLB Previews 
NBA Previews 
NHL Previews 
Soccer Previews 
Prediction 
Odds 
Last Recap 
Game Picks 
Top Handicapper 
Philadelphia Eagles vs Los Angeles Rams September 21st 2025
The Los Angeles Rams travel to Lincoln Financial Field to take on the Philadelphia Eagles in Week 3 of the 2025 NFL season. Both teams come into this game with a perfect 2-0 record, setting the stage for a competitive contest. Fans can catch the action on FOX at 1:00 PM on Sunday, September 21, 2025.
The Rams, under head coach Sean McVay, have shown strong performances both at home and on the road. Meanwhile, the Eagles, led by head coach Nick Sirianni, aim to defend their home turf. The weather forecast predicts a mild day with broken clouds, adding a touch of unpredictability to the outdoor game.
Rams vs Eagles Key Information
- Sport: NFL Football
- Teams: Los Angeles Rams vs. Philadelphia Eagles
- Venue: Lincoln Financial Field in Philadelphia, PA
- Date: Sunday, September 21, 2025
- Betting Odds: Rams Moneyline +157, Eagles Moneyline -187, Rams Spread +3.5 (-117), Eagles Spread -3.5 (-104), Total Over/Under 44.5 (-110)
The Los Angeles Rams travel to Philadelphia for a showdown with the Philadelphia Eagles in a battle of unbeatens. Both teams are 2-0, and this matchup could be an early NFC playoff preview. For more previews and betting breakdowns, visit the NFL picks page.
Game Odds
| Team | Spread | Moneyline | Total |
|---|---|---|---|
| Los Angeles Rams | +3.5 (-110) | +150 | O 44.5 (-110) |
| Philadelphia Eagles | -3.5 (-110) | -175 | U 44.5 (-110) |
(odds subject to change – get the latest updates on the NFL odds board)
The Rams Can Win If…
Los Angeles is coming off a 33-19 victory over Tennessee. Matthew Stafford threw for 298 yards and two touchdowns, while Davante Adams recorded 106 yards and a score.
The Rams’ passing game is thriving — Stafford ranks sixth in the league with 543 passing yards, and Puka Nacua is fourth in receiving with 221 yards. This air attack gives the Rams the ability to stretch the field against any secondary.
Defensively, Los Angeles has leaned on its turnover creation, ranking seventh in interceptions last season. With Kam Curl and Kobie Turner pressuring opposing quarterbacks, the Rams can force Philadelphia into mistakes. For more insight on all matchups, check out the NFL betting guide.
The Eagles Can Win If…
Philadelphia edged Kansas City 20-17 last week behind Saquon Barkley’s 88 rushing yards and Jalen Hurts’ efficient passing. Barkley is the centerpiece of an Eagles rushing attack that ranked second in the NFL last season.
The defense remains elite, finishing last season ranked second in opponent scoring. With Hurts projected to throw for over 200 yards and Barkley healthy, Philadelphia has the balance to grind out another win at home.
If the offensive line holds up against the Rams’ front seven, the Eagles should be in position to remain undefeated. Explore more on both teams’ season outlooks in the NFL teams section.
Key Betting Trends
| Trend | Stat |
|---|---|
| Rams ATS | 4-1 in last 5 as underdogs |
| Eagles ATS | 8-0 in last 8 home games |
| Rams O/U | Over in 4 of last 5 games as underdogs |
| Eagles O/U | Under in 8 of last 13 games overall |
See how these trends connect to postseason futures on the Super Bowl odds blog.
Projected Score
| Team | Score |
|---|---|
| Philadelphia Eagles | 27 |
| Los Angeles Rams | 20 |
The Lean
The Eagles are 3.5-point favorites, and the model projects a 27-20 Philadelphia victory. The Eagles’ defense and home-field advantage make them the sharper side. The pick is Eagles -3.5.
The total is set at 44.5. While Philadelphia tends to go under, the Rams’ recent games lean over. With a projected total of 47 points, the recommendation is to take the over.
For live updates and expert breakdowns each week, head to the NFL scores and stats hub.
