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New England Patriots vs Tennessee Titans Betting Preview
The New England Patriots head south to face the Tennessee Titans in Week 7 of the NFL season. Kickoff is set for Sunday, October 19, 2025, at 1:00 PM ET from Nissan Stadium in Nashville, airing live on CBS.
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The Patriots (4-2) are riding a three-game win streak and remain undefeated on the road this season. Meanwhile, the Titans (1-5) are entering a new era under interim head coach Mike McCoy after parting ways with Brian Callahan earlier this week. McCoy will look to steady a struggling offense against a Patriots squad that’s found rhythm behind rookie quarterback Drake Maye.
Find all NFL lines, totals, and odds updates on the scores and odds page.
Movement and Odds
The Patriots opened as 7-point favorites (-340 moneyline), while the Titans sit at +270. The total is set at 42 points. Early money has come in on New England, given their hot streak and Tennessee’s offensive limitations.
Keep up with live movement, injury updates, and betting splits at the NFL picks and predictions hub.
Matchup Breakdown
New England’s turnaround under Mike Vrabel has been swift. In his first season as head coach — and now facing his former team — Vrabel has rebuilt the Patriots’ toughness and execution. Behind rookie QB Drake Maye, New England ranks near the top in passing efficiency, and Maye’s 73.2% completion rate has stabilized an offense that once struggled with turnovers.
The Patriots’ win over the Saints (25-19) highlighted how efficient they’ve become in high-pressure situations. Maye connected with Kayshon Boutte twice for touchdowns, while the defense limited Derek Carr’s big-play attempts. Their ability to close games has turned them into a dark horse in the AFC playoff race.
Tennessee’s story is the opposite — searching for identity. Rookie QB Cam Ward, the first overall pick in the 2025 NFL Draft, has shown flashes but little consistency. The Titans’ offense ranks 31st in scoring (13.8 PPG) and last in total yardage. Mike McCoy’s first task is unlocking the potential of Ward and wideout Calvin Ridley, who’s been battling a hamstring injury.
If Tennessee wants a chance, it’ll come from their defense. Veteran Jeffery Simmons continues to anchor the front line, and the Titans rank among the top 10 in opponent interceptions. However, without a reliable offensive rhythm, the Titans’ defense can only do so much.
For more long-term outlooks, check the Super Bowl odds and predictions blog for how both teams’ playoff chances are trending.
Injuries and Conditions
New England Patriots
- Jaylinn Hawkins (Hamstring) Questionable
- Anfernee Jennings (Ankle) Questionable
- Antonio Gibson (Knee) Out
- Stefon Diggs (Chest) Limited
- Christian Barmore (Rest) Limited
Tennessee Titans
- Calvin Ridley (Hamstring) Questionable
- Arden Key (Quad) Questionable
- Jeffery Simmons (Rest) Questionable
- Will Levis (Shoulder) Out
- Mike Brown (Knee) Out
Both teams enter the matchup banged up, but New England’s depth gives them the advantage. If Ridley can’t go, Tennessee’s offense could once again rely heavily on rookie running back Tony Pollard, who’s averaged 60+ rushing yards per game.
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Best Bets and Prediction
The Patriots have been excellent on the road (3-0 ATS) and continue to find ways to win behind efficient quarterback play and situational defense. The Titans, on the other hand, are transitioning under a new coach and lack offensive rhythm.
Projected Score: Patriots 24, Titans 14
Best Bet: Patriots -7 (-110)
Secondary Lean: Under 42 (-112)
Expect the Patriots’ defense to limit Tennessee’s production, while Drake Maye and Kayshon Boutte connect again for a key score.
Get full handicapping breakdowns and consensus data from verified experts on the ScoresAndStats best handicappers leaderboard and check the NFL expert betting guide for prop market insights.
