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Washington Nationals vs Atlanta Braves Picks and Predictions April 21st 2026
Atlanta comes into Tuesday night at 16-7, first in the NL East, and riding a six-game winning streak after Monday’s 9-4 win in Washington. The Nationals are 10-13, third in the division, and just 2-8 at home, so this is already starting to feel like a tough spot for them even before you get to the pitching matchup. First pitch is set for 6:45 p.m. ET at Nationals Park, with Reynaldo López facing Foster Griffin. The weather should stay pretty quiet. Washington is expected to sit in the low 60s around first pitch with mostly clear skies and only a light breeze, so this does not look like one of those games where the forecast overwhelms the baseball handicap. That
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Boston Red Sox vs New York Yankees Picks and Predictions April 21st 2026
The Yankees open their first 2026 series against Boston on Tuesday night at Fenway Park, carrying a 13-9 record, first place in the AL East, and a three-game winning streak after sweeping Kansas City. Boston comes in at 9-13, fourth in the division, but the Red Sox did just close their Detroit series with an 8-6 win on Monday. First pitch is set for 6:45 p.m. ET, with Luis Gil starting for New York and Connelly Early getting the ball for Boston. TV coverage is listed on TBS, YES, and NESN+, and the market has this game priced close to a coin flip. Fenway weather looks cool and a little damp, but not extreme enough to completely hijack the handicap.
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New York Mets vs Minnesota Twins Picks and Predictions April 21st 2026
The Twins open this interleague set at Citi Field on Tuesday night with an 11-11 record and a four-game losing streak after getting swept at home by Cincinnati. The Mets are in even worse shape at 7-15, last in the NL East, and have dropped 11 straight, their longest skid since 2004. First pitch is set for 7:10 p.m. ET, and the listed TV coverage is Twins.TV Presented by Progressive and SNY. One important update from your original setup: Minnesota is not sending Mick Abel. He went on the 15-day injured list Monday with right elbow inflammation, so Simeon Woods Richardson gets the start opposite Nolan McLean. The weather should stay fairly quiet, with temperatures in the upper 40s, light
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Chicago Cubs vs Philadelphia Phillies Picks and Predictions April 21st 2026
The Phillies head back into Wrigley Field on Tuesday night at 8-14, and the skid is getting hard to ignore now. Philadelphia has dropped six straight, while Chicago is moving the other way at 13-9 with six consecutive wins. First pitch is set for 7:40 p.m. ET, with Jesús Luzardo facing Shota Imanaga, and the current market has the Cubs as a short home favorite. The game is listed on NBC Sports Philadelphia and Marquee Sports Network. The weather looks a little cleaner than the early-day forecast suggested. Chicago has a thunderstorm risk around early evening, but conditions trend cloudier and then partly cloudy by game time, with temperatures settling in the upper 60s. At Wrigley, that always matters, but
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Kansas City Royals vs Baltimore Orioles Picks and Predictions April 21st 2026
The Orioles go back to work at Kauffman Stadium on Tuesday night after taking Monday’s opener 7-5 in 12 innings. That win moved Baltimore to 11-12 and kept the club in third place in the AL East, while Kansas City dropped to 7-16 and stretched its losing streak to eight games, still stuck in fifth in the AL Central. First pitch is set for 7:40 p.m. ET, and the listed starters are Shane Baz for Baltimore and Kris Bubic for Kansas City. The market has the Royals as a modest home favorite with a total of 9. The weather should stay in the background. Kansas City is expected to be warm and mostly clear around first pitch, with temperatures in

MLB game preview for Rangers vs Pirates featuring a pitcher in a black Pirates uniform mid-throw with MLB logo and game details.

Texas Rangers vs Pittsburgh Pirates Picks and Predictions April 21st 2026

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The Pirates open this interleague series at Globe Life Field on Tuesday night sitting at 13-9, third in the NL Central, and … more

Baseball game preview for Rockies vs Padres with batter and catcher in action and MLB logo.

Colorado Rockies vs San Diego Padres Picks and Predictions April 21st 2026

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San Diego opens a three-game set at Coors Field on Tuesday night with a 15-7 record, second place in the NL West, … more

MLB game preview graphic featuring players from the Angels and Blue Jays with text and the MLB logo.

Los Angeles Angels vs Toronto Blue Jays Picks and Predictions April 21st 2026

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Toronto goes back to work at Angel Stadium on Tuesday night after taking Monday’s opener 5-2, so this is not quite the … more

MLB game preview for Diamondbacks vs White Sox with a background image of players on the field in action.

Arizona Diamondbacks vs Chicago White Sox Picks and Predictions April 21st 2026

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The White Sox open a three-game set at Chase Field on Tuesday night with first pitch scheduled for 9:40 p.m. ET. Chicago … more

MLB game preview featuring Mariners vs Athletics with two Athletics players celebrating, including one with "McNeil 22" on jersey.

Seattle Mariners vs Athletics Picks and Predictions April 21st 2026

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The Athletics head into T-Mobile Park on Tuesday night at 12-11, and after Monday’s 6-4 win in Seattle they sit alone atop … more